Selective trophic effect of L-carnitine in type I and IIa skeletal muscle fibers
Selective trophic effect of L-carnitine in type I and IIa skeletal muscle fibers. Biopsies were taken from the vastus lateralis muscle of 26 chronic uremic patients before and after a 24-week treatment with L-carnitine given at the dose of 2g i.v. at the end of hemodialysis, or in dialysis solution,...
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| Veröffentlicht in: | Kidney international 1994-12, Vol.46 (6), p.1616-1619 |
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| container_title | Kidney international |
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| creator | Giovenali, Paolo Fenocchio, Daniela Montanari, Giuseppe Cancellotti, Corrado D'Iddio, Stefania Buoncristiani, Umberto Pelagaggia, Maurizio Ribacchi, Rodolfo |
| description | Selective trophic effect of L-carnitine in type I and IIa skeletal muscle fibers. Biopsies were taken from the vastus lateralis muscle of 26 chronic uremic patients before and after a 24-week treatment with L-carnitine given at the dose of 2g i.v. at the end of hemodialysis, or in dialysis solution, or per os twice daily. The aim of the study was to evaluate both the muscle morphology in dialyzed subjects and the modification provoked by the therapy. All patients manifested a significant, even if variable, degree of muscular atrophy which involved all types of muscle fibers. After the treatment there was an increase of about 7% in the diameter of type I and type IIa fibers, which can utilize carnitine for fatty acid oxidation to produce energy, and a reduction in the atrophic fibers. No noteworthy changes were documented in type lib fibers, which depend on glycolysis for energy production. |
| doi_str_mv | 10.1038/ki.1994.460 |
| format | Article |
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Biopsies were taken from the vastus lateralis muscle of 26 chronic uremic patients before and after a 24-week treatment with L-carnitine given at the dose of 2g i.v. at the end of hemodialysis, or in dialysis solution, or per os twice daily. The aim of the study was to evaluate both the muscle morphology in dialyzed subjects and the modification provoked by the therapy. All patients manifested a significant, even if variable, degree of muscular atrophy which involved all types of muscle fibers. After the treatment there was an increase of about 7% in the diameter of type I and type IIa fibers, which can utilize carnitine for fatty acid oxidation to produce energy, and a reduction in the atrophic fibers. No noteworthy changes were documented in type lib fibers, which depend on glycolysis for energy production.</description><identifier>ISSN: 0085-2538</identifier><identifier>EISSN: 1523-1755</identifier><identifier>DOI: 10.1038/ki.1994.460</identifier><identifier>PMID: 7700019</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Carnitine - blood ; Carnitine - metabolism ; Carnitine - therapeutic use ; Energy Metabolism - drug effects ; Female ; Humans ; Hypertrophy ; Male ; Middle Aged ; Muscle Contraction - drug effects ; Muscle, Skeletal - drug effects ; Muscle, Skeletal - pathology ; Muscle, Skeletal - physiopathology ; Muscular Atrophy - drug therapy ; Muscular Atrophy - pathology ; Muscular Atrophy - prevention & control ; Renal Dialysis ; Safety ; Space life sciences ; Uremia - drug therapy ; Uremia - pathology ; Uremia - physiopathology</subject><ispartof>Kidney international, 1994-12, Vol.46 (6), p.1616-1619</ispartof><rights>1994 International Society of Nephrology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c433t-eeb1c2a7cacf177203d76f64e9c0de306ac93e80486ea10030259f4320d958293</citedby><cites>FETCH-LOGICAL-c433t-eeb1c2a7cacf177203d76f64e9c0de306ac93e80486ea10030259f4320d958293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7700019$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Giovenali, Paolo</creatorcontrib><creatorcontrib>Fenocchio, Daniela</creatorcontrib><creatorcontrib>Montanari, Giuseppe</creatorcontrib><creatorcontrib>Cancellotti, Corrado</creatorcontrib><creatorcontrib>D'Iddio, Stefania</creatorcontrib><creatorcontrib>Buoncristiani, Umberto</creatorcontrib><creatorcontrib>Pelagaggia, Maurizio</creatorcontrib><creatorcontrib>Ribacchi, Rodolfo</creatorcontrib><title>Selective trophic effect of L-carnitine in type I and IIa skeletal muscle fibers</title><title>Kidney international</title><addtitle>Kidney Int</addtitle><description>Selective trophic effect of L-carnitine in type I and IIa skeletal muscle fibers. 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No noteworthy changes were documented in type lib fibers, which depend on glycolysis for energy production.</description><subject>Carnitine - blood</subject><subject>Carnitine - metabolism</subject><subject>Carnitine - therapeutic use</subject><subject>Energy Metabolism - drug effects</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertrophy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Muscle Contraction - drug effects</subject><subject>Muscle, Skeletal - drug effects</subject><subject>Muscle, Skeletal - pathology</subject><subject>Muscle, Skeletal - physiopathology</subject><subject>Muscular Atrophy - drug therapy</subject><subject>Muscular Atrophy - pathology</subject><subject>Muscular Atrophy - prevention & control</subject><subject>Renal Dialysis</subject><subject>Safety</subject><subject>Space life sciences</subject><subject>Uremia - drug therapy</subject><subject>Uremia - pathology</subject><subject>Uremia - physiopathology</subject><issn>0085-2538</issn><issn>1523-1755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkEtLAzEUhYMotVZXroWs3MjUm8lkMllK8VEoKKjrkGZuMHYeNZkW-u9NaXHl6j7OuQfuR8g1gykDXt2v_JQpVUyLEk7ImImcZ0wKcUrGAJXIcsGrc3IR4zekWXEYkZGUqWdqTN7esUE7-C3SIfTrL28pOpc2tHd0kVkTOj_4Dqnv6LBbI51T09V0Pjc0rtLpYBrabqJtkDq_xBAvyZkzTcSrY52Qz6fHj9lLtnh9ns8eUmTB-ZAhLpnNjbTGOiZlDryWpSsLVBZq5FAaqzhWUFQlGgbAIRfKFTyHWokqV3xCbg-569D_bDAOuvXRYtOYDvtN1FJKJVRVJuPdwWhDH2NAp9fBtybsNAO956dXXu_56cQvuW-OsZtli_Wf9wgs6eKgY_pt6zHoaD12FmsfEjVd9_7f3F_WoHvc</recordid><startdate>19941201</startdate><enddate>19941201</enddate><creator>Giovenali, Paolo</creator><creator>Fenocchio, Daniela</creator><creator>Montanari, Giuseppe</creator><creator>Cancellotti, Corrado</creator><creator>D'Iddio, Stefania</creator><creator>Buoncristiani, Umberto</creator><creator>Pelagaggia, Maurizio</creator><creator>Ribacchi, Rodolfo</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19941201</creationdate><title>Selective trophic effect of L-carnitine in type I and IIa skeletal muscle fibers</title><author>Giovenali, Paolo ; Fenocchio, Daniela ; Montanari, Giuseppe ; Cancellotti, Corrado ; D'Iddio, Stefania ; Buoncristiani, Umberto ; Pelagaggia, Maurizio ; Ribacchi, Rodolfo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c433t-eeb1c2a7cacf177203d76f64e9c0de306ac93e80486ea10030259f4320d958293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Carnitine - blood</topic><topic>Carnitine - metabolism</topic><topic>Carnitine - therapeutic use</topic><topic>Energy Metabolism - drug effects</topic><topic>Female</topic><topic>Humans</topic><topic>Hypertrophy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Muscle Contraction - drug effects</topic><topic>Muscle, Skeletal - drug effects</topic><topic>Muscle, Skeletal - pathology</topic><topic>Muscle, Skeletal - physiopathology</topic><topic>Muscular Atrophy - drug therapy</topic><topic>Muscular Atrophy - pathology</topic><topic>Muscular Atrophy - prevention & control</topic><topic>Renal Dialysis</topic><topic>Safety</topic><topic>Space life sciences</topic><topic>Uremia - drug therapy</topic><topic>Uremia - pathology</topic><topic>Uremia - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Giovenali, Paolo</creatorcontrib><creatorcontrib>Fenocchio, Daniela</creatorcontrib><creatorcontrib>Montanari, Giuseppe</creatorcontrib><creatorcontrib>Cancellotti, Corrado</creatorcontrib><creatorcontrib>D'Iddio, Stefania</creatorcontrib><creatorcontrib>Buoncristiani, Umberto</creatorcontrib><creatorcontrib>Pelagaggia, Maurizio</creatorcontrib><creatorcontrib>Ribacchi, Rodolfo</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Kidney international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Giovenali, Paolo</au><au>Fenocchio, Daniela</au><au>Montanari, Giuseppe</au><au>Cancellotti, Corrado</au><au>D'Iddio, Stefania</au><au>Buoncristiani, Umberto</au><au>Pelagaggia, Maurizio</au><au>Ribacchi, Rodolfo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Selective trophic effect of L-carnitine in type I and IIa skeletal muscle fibers</atitle><jtitle>Kidney international</jtitle><addtitle>Kidney Int</addtitle><date>1994-12-01</date><risdate>1994</risdate><volume>46</volume><issue>6</issue><spage>1616</spage><epage>1619</epage><pages>1616-1619</pages><issn>0085-2538</issn><eissn>1523-1755</eissn><abstract>Selective trophic effect of L-carnitine in type I and IIa skeletal muscle fibers. 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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Carnitine - blood Carnitine - metabolism Carnitine - therapeutic use Energy Metabolism - drug effects Female Humans Hypertrophy Male Middle Aged Muscle Contraction - drug effects Muscle, Skeletal - drug effects Muscle, Skeletal - pathology Muscle, Skeletal - physiopathology Muscular Atrophy - drug therapy Muscular Atrophy - pathology Muscular Atrophy - prevention & control Renal Dialysis Safety Space life sciences Uremia - drug therapy Uremia - pathology Uremia - physiopathology |
| title | Selective trophic effect of L-carnitine in type I and IIa skeletal muscle fibers |
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