Hepatitis E seroprevalence in selected individuals in South Africa
Antibodies to the hepatitis E virus (HEV) were detected by an enzyme immunoassay using synthetic HEV peptides. Positive anti‐HEV results were confirmed by a neutralization assay and Western blot analysis. Anti‐HEV was detected in 10 of 555 canoeists (1.8%) with regular exposure to sewage‐polluted wa...
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| Veröffentlicht in: | Journal of medical virology 1994-12, Vol.44 (4), p.384-388 |
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| container_title | Journal of medical virology |
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| creator | Grabow, W. O. K. Favorov, M. O. Khudyakova, N. S. Taylor, M. B. Fields, H. A. |
| description | Antibodies to the hepatitis E virus (HEV) were detected by an enzyme immunoassay using synthetic HEV peptides. Positive anti‐HEV results were confirmed by a neutralization assay and Western blot analysis. Anti‐HEV was detected in 10 of 555 canoeists (1.8%) with regular exposure to sewage‐polluted water and in 6 of 227 (2.6%) medical students with minimal exposure. The overall prevalence of 16 per 782 individuals (2.05%) suggests that HEV may be endemic in South Africa. This is confirmed by indications of infection earlier than the third decade of life, and by individuals with anti‐HEV who had rarely or never been out of the country. The prevalence data suggest that regular exposure to sewage‐polluted water was not a particular risk factor. None of the individuals with anti‐HEV had a history of clinical hepatitis E, suggesting sporadic low level subclinical cases of infection. This is in agreement with the absence of reports on clinical cases or outbreaks of hepatitis E in South Africa. © 1994 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/jmv.1890440412 |
| format | Article |
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O. K. ; Favorov, M. O. ; Khudyakova, N. S. ; Taylor, M. B. ; Fields, H. A.</creator><creatorcontrib>Grabow, W. O. K. ; Favorov, M. O. ; Khudyakova, N. S. ; Taylor, M. B. ; Fields, H. A.</creatorcontrib><description>Antibodies to the hepatitis E virus (HEV) were detected by an enzyme immunoassay using synthetic HEV peptides. Positive anti‐HEV results were confirmed by a neutralization assay and Western blot analysis. Anti‐HEV was detected in 10 of 555 canoeists (1.8%) with regular exposure to sewage‐polluted water and in 6 of 227 (2.6%) medical students with minimal exposure. The overall prevalence of 16 per 782 individuals (2.05%) suggests that HEV may be endemic in South Africa. This is confirmed by indications of infection earlier than the third decade of life, and by individuals with anti‐HEV who had rarely or never been out of the country. The prevalence data suggest that regular exposure to sewage‐polluted water was not a particular risk factor. None of the individuals with anti‐HEV had a history of clinical hepatitis E, suggesting sporadic low level subclinical cases of infection. 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O. K.</creatorcontrib><creatorcontrib>Favorov, M. O.</creatorcontrib><creatorcontrib>Khudyakova, N. S.</creatorcontrib><creatorcontrib>Taylor, M. B.</creatorcontrib><creatorcontrib>Fields, H. A.</creatorcontrib><title>Hepatitis E seroprevalence in selected individuals in South Africa</title><title>Journal of medical virology</title><addtitle>J. Med. Virol</addtitle><description>Antibodies to the hepatitis E virus (HEV) were detected by an enzyme immunoassay using synthetic HEV peptides. Positive anti‐HEV results were confirmed by a neutralization assay and Western blot analysis. Anti‐HEV was detected in 10 of 555 canoeists (1.8%) with regular exposure to sewage‐polluted water and in 6 of 227 (2.6%) medical students with minimal exposure. The overall prevalence of 16 per 782 individuals (2.05%) suggests that HEV may be endemic in South Africa. This is confirmed by indications of infection earlier than the third decade of life, and by individuals with anti‐HEV who had rarely or never been out of the country. The prevalence data suggest that regular exposure to sewage‐polluted water was not a particular risk factor. None of the individuals with anti‐HEV had a history of clinical hepatitis E, suggesting sporadic low level subclinical cases of infection. This is in agreement with the absence of reports on clinical cases or outbreaks of hepatitis E in South Africa. © 1994 Wiley‐Liss, Inc.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Hepatitis Antibodies - analysis</subject><subject>hepatitis E virus</subject><subject>Hepatitis E virus - immunology</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immunoglobulin G - analysis</subject><subject>Immunoglobulin M - analysis</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>NANBNC</subject><subject>Prevalence</subject><subject>recreation</subject><subject>Seroepidemiologic Studies</subject><subject>South Africa - epidemiology</subject><subject>subclinical infection</subject><subject>Viral diseases</subject><subject>Viral hepatitis</subject><subject>waterborne</subject><issn>0146-6615</issn><issn>1096-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtPGzEQxi3UCgLttTekHCpum_ox68cREI9WQIWAIvViOd6xMGyywd5Ny39fo0SpODEXj775fTPWR8gXRieMUv7tcbacMG0oAAXGt8iIUSMrQxX7QEaUgaykZPUO2c35kVKqDefbZFtpo4TUI3J0jgvXxz7m8ck4Y-oWCZeuxbnHcZwXpUXfY1P6Ji5jM7g2v-o33dA_jA9Dit59Ih9DkfHz-t0jd6cnt8fn1cXPs-_HhxeVB6F5VXsB2rkpSOnACR6AicDd1NcGGhaY1o3ztYdpEFIBADJAIzE4AbxUEHvkYLV3kbrnAXNvZzF7bFs3x27IVillaqn5uyCTigtguoCTFehTl3PCYBcpzlx6sYza13RtSdf-T7cY9tebh-kMmw2-jrPMv67nLnvXhuTmPuYNJmojuBYFMyvsT2zx5Z2j9sflrzdfqFbemHv8u_G69GSlEqq291dn9vr66Le4laf2UvwDY_ChXQ</recordid><startdate>199412</startdate><enddate>199412</enddate><creator>Grabow, W. O. K.</creator><creator>Favorov, M. O.</creator><creator>Khudyakova, N. S.</creator><creator>Taylor, M. B.</creator><creator>Fields, H. A.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>199412</creationdate><title>Hepatitis E seroprevalence in selected individuals in South Africa</title><author>Grabow, W. O. K. ; Favorov, M. O. ; Khudyakova, N. S. ; Taylor, M. B. ; Fields, H. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4382-5c348aab466a4a32f413f2abc594d1f188dac5c4bf367444e14e96efa342222f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Hepatitis Antibodies - analysis</topic><topic>hepatitis E virus</topic><topic>Hepatitis E virus - immunology</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Immunoglobulin G - analysis</topic><topic>Immunoglobulin M - analysis</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>NANBNC</topic><topic>Prevalence</topic><topic>recreation</topic><topic>Seroepidemiologic Studies</topic><topic>South Africa - epidemiology</topic><topic>subclinical infection</topic><topic>Viral diseases</topic><topic>Viral hepatitis</topic><topic>waterborne</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grabow, W. O. K.</creatorcontrib><creatorcontrib>Favorov, M. O.</creatorcontrib><creatorcontrib>Khudyakova, N. S.</creatorcontrib><creatorcontrib>Taylor, M. B.</creatorcontrib><creatorcontrib>Fields, H. A.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of medical virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grabow, W. O. K.</au><au>Favorov, M. O.</au><au>Khudyakova, N. S.</au><au>Taylor, M. B.</au><au>Fields, H. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hepatitis E seroprevalence in selected individuals in South Africa</atitle><jtitle>Journal of medical virology</jtitle><addtitle>J. Med. Virol</addtitle><date>1994-12</date><risdate>1994</risdate><volume>44</volume><issue>4</issue><spage>384</spage><epage>388</epage><pages>384-388</pages><issn>0146-6615</issn><eissn>1096-9071</eissn><coden>JMVIDB</coden><abstract>Antibodies to the hepatitis E virus (HEV) were detected by an enzyme immunoassay using synthetic HEV peptides. Positive anti‐HEV results were confirmed by a neutralization assay and Western blot analysis. Anti‐HEV was detected in 10 of 555 canoeists (1.8%) with regular exposure to sewage‐polluted water and in 6 of 227 (2.6%) medical students with minimal exposure. The overall prevalence of 16 per 782 individuals (2.05%) suggests that HEV may be endemic in South Africa. This is confirmed by indications of infection earlier than the third decade of life, and by individuals with anti‐HEV who had rarely or never been out of the country. The prevalence data suggest that regular exposure to sewage‐polluted water was not a particular risk factor. None of the individuals with anti‐HEV had a history of clinical hepatitis E, suggesting sporadic low level subclinical cases of infection. This is in agreement with the absence of reports on clinical cases or outbreaks of hepatitis E in South Africa. © 1994 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>7897368</pmid><doi>10.1002/jmv.1890440412</doi><tpages>5</tpages></addata></record> |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | Adult Biological and medical sciences Female Follow-Up Studies Hepatitis Antibodies - analysis hepatitis E virus Hepatitis E virus - immunology Human viral diseases Humans Immunoglobulin G - analysis Immunoglobulin M - analysis Infectious diseases Male Medical sciences NANBNC Prevalence recreation Seroepidemiologic Studies South Africa - epidemiology subclinical infection Viral diseases Viral hepatitis waterborne |
| title | Hepatitis E seroprevalence in selected individuals in South Africa |
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