Thrombin triggers the de novo expression of an inducible NO synthase in porcine aortic valve endothelial cells

The nitric oxide (NO) production by porcine aortic valve endothelial cells was estimated in cusps incubated at 37°C by measuring their cyclic GMP content and the nitrite levels of the incubation medium. After a stabilization period, incubations for 5 min with acetylcholine, bradykinin, ADP and bovin...

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Veröffentlicht in:	European journal of pharmacology 1995-10, Vol.291 (2), p.67-72
Hauptverfasser:	De Meyer, Erwin, Van Hove, Cor E., Feng, Xiao Jie, Rampart, Marc, Herman, Arnold G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - drug effects Aorta - enzymology Aortic valve cusp Arginine - analogs & derivatives Arginine - pharmacology Biological and medical sciences Blood vessels and receptors Cyclic GMP Cyclic GMP - metabolism Endothelium, Vascular - drug effects Endothelium, Vascular - enzymology Enzyme Inhibitors - pharmacology Enzyme-Linked Immunosorbent Assay Fundamental and applied biological sciences. Psychology NG-Nitroarginine Methyl Ester Nitric oxide (NO) Nitric Oxide Synthase - biosynthesis Nitric Oxide Synthase - metabolism Nitric oxide synthase, constitutive Nitric oxide synthase, inducible porcine Swine Thrombin Thrombin - pharmacology Vertebrates: cardiovascular system
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