Absence of enantioselectivity in the pharmacodynamics of P450 2B induction by 5-ethyl-5-phenylhydantoin in the male rat liver or in cultured rat hepatocytes

To explore the enantioselectivity of ligand interaction with the putative phenobarbital receptor, the pharmacodynamics of cytochrome P450 2B (CYP2B) induction by racemic 5‐ethyl‐5‐phen‐ylhydantoin and its two enantiomers were investigated in the male F344/NCr rat and in cultured adult male rat hepat...

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Veröffentlicht in:	Journal of biochemical toxicology 1994-12, Vol.9 (6), p.279-288
Hauptverfasser:	Nims, Raymond W., Sidhu, Jaspreet S., Thomas, Paul E., Mellini, Donna W., Nelson, Victor C., Omiecinski, Curtis J., Lubet, Ronald A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured CYP2B Cytochrome P-450 Enzyme System - biosynthesis Enantioselectivity of Enzyme Induction - drug effects Induction of Induction of CYP2B Liver - enzymology Male Mephenytoin - analogs & derivatives Mephenytoin - pharmacology Organ Size - drug effects Pharmacodynamics of Pharmacodynamics of CYP2B Rats Rats, Inbred F344 RNA - biosynthesis Stereoisomerism
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