Repetitive exposure to the hot-plate test produces stress induced analgesia and alters β-endorphin neuronal transmission within the periaqueductal gray of the rat
Repetitive exposure of rats to a hot plate induced a novel non-opioid form of stress induced analgesia. The exposure caused a persistent 1.5–2 s increase in tail flick latency which was not attenuated by systemic naltrexone, but was completely inhibited by systemic MK-801. Concomitantly, alterations...
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| Veröffentlicht in: | Brain research 1994-12, Vol.667 (2), p.283-286 |
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| creator | Hawranko, Alyssa A. Monroe, Philip J. Smith, David J. |
| description | Repetitive exposure of rats to a hot plate induced a novel non-opioid form of stress induced analgesia. The exposure caused a persistent 1.5–2 s increase in tail flick latency which was not attenuated by systemic naltrexone, but was completely inhibited by systemic MK-801. Concomitantly, alterations occurred in the ability to pharmacologically distinguish multiple β-endorphin receptors in the periaqueductal gray. Thus, in response to different forms of stress, different pathways may be activated by β-endorphin, resulting in stress induced analgesias with varied pharmacological characteristics (e.g., opioid and non-opioid). |
| doi_str_mv | 10.1016/0006-8993(94)91508-3 |
| format | Article |
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The exposure caused a persistent 1.5–2 s increase in tail flick latency which was not attenuated by systemic naltrexone, but was completely inhibited by systemic MK-801. Concomitantly, alterations occurred in the ability to pharmacologically distinguish multiple β-endorphin receptors in the periaqueductal gray. 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Psychology ; Heating ; Male ; Microinjections ; Molecular Sequence Data ; Morphine ; Narcotic Antagonists ; Non-opioid ; Opioid ; Pain - physiopathology ; Periaqueductal gray ; Periaqueductal Gray - metabolism ; Periaqueductal Gray - physiology ; Rat ; Rats ; Rats, Sprague-Dawley ; Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors ; Stress ; Stress, Physiological - metabolism ; Stress, Physiological - physiopathology ; Synaptic Transmission ; Vertebrates: nervous system and sense organs ; β-Endorphin</subject><ispartof>Brain research, 1994-12, Vol.667 (2), p.283-286</ispartof><rights>1994 Elsevier Science B.V. All rights reserved</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-8af99562479da90d9adaa0b659f83c2689ae1f8ee65cf852ef7848b3e52d1fd3</citedby><cites>FETCH-LOGICAL-c417t-8af99562479da90d9adaa0b659f83c2689ae1f8ee65cf852ef7848b3e52d1fd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0006899394915083$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3345423$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7697368$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hawranko, Alyssa A.</creatorcontrib><creatorcontrib>Monroe, Philip J.</creatorcontrib><creatorcontrib>Smith, David J.</creatorcontrib><title>Repetitive exposure to the hot-plate test produces stress induced analgesia and alters β-endorphin neuronal transmission within the periaqueductal gray of the rat</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Repetitive exposure of rats to a hot plate induced a novel non-opioid form of stress induced analgesia. The exposure caused a persistent 1.5–2 s increase in tail flick latency which was not attenuated by systemic naltrexone, but was completely inhibited by systemic MK-801. Concomitantly, alterations occurred in the ability to pharmacologically distinguish multiple β-endorphin receptors in the periaqueductal gray. Thus, in response to different forms of stress, different pathways may be activated by β-endorphin, resulting in stress induced analgesias with varied pharmacological characteristics (e.g., opioid and non-opioid).</description><subject>Amino Acid Sequence</subject><subject>Analgesia</subject><subject>Animals</subject><subject>beta-Endorphin - metabolism</subject><subject>Biological and medical sciences</subject><subject>Cytidine Triphosphate - pharmacology</subject><subject>Dizocilpine Maleate</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Heating</subject><subject>Male</subject><subject>Microinjections</subject><subject>Molecular Sequence Data</subject><subject>Morphine</subject><subject>Narcotic Antagonists</subject><subject>Non-opioid</subject><subject>Opioid</subject><subject>Pain - physiopathology</subject><subject>Periaqueductal gray</subject><subject>Periaqueductal Gray - metabolism</subject><subject>Periaqueductal Gray - physiology</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</subject><subject>Stress</subject><subject>Stress, Physiological - metabolism</subject><subject>Stress, Physiological - physiopathology</subject><subject>Synaptic Transmission</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>β-Endorphin</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2KFDEQxxtR1nH1DRRyENFDa9LpzsdFkMUvWBBk7yGTVHYiPZ02lV7d5_ENfBCfyfTOMEc9JZX61T9V9W-ap4y-ZpSJN5RS0Sqt-Uvdv9JsoKrl95oNU7JrRdfT-83mhDxsHiF-qyHnmp41Z1JoyYXaNL--wgwllngDBH7OCZcMpCRSdkB2qbTzaEt9ACxkzskvDpBgyYBI4rSGntjJjteA0dZbjcYCGcmf3y1MPuV5FycywZJTpUjJdsJ9RIxpIj9iWZPrTzPkaL8vUAVLxa6zvSUp3KWyLY-bB8GOCE-O53lz9eH91cWn9vLLx88X7y5b1zNZWmWD1kOdXGpvNfXaemvpVgw6KO46obQFFhSAGFxQQwdBql5tOQydZ8Hz8-bFQbYOWnvBYmqnDsbRTpAWNFJK3Ylu-C_IhKS647qC_QF0OSFmCGbOcW_zrWHUrB6a1SCzGmR0b-48NLyWPTvqL9s9-FPR0bSaf37MW3R2DHWpLuIJ47wf-m6VeXvAoO7sJkI26CJM1bKYwRXjU_x3H38Bx0G9jA</recordid><startdate>19941226</startdate><enddate>19941226</enddate><creator>Hawranko, Alyssa A.</creator><creator>Monroe, Philip J.</creator><creator>Smith, David J.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19941226</creationdate><title>Repetitive exposure to the hot-plate test produces stress induced analgesia and alters β-endorphin neuronal transmission within the periaqueductal gray of the rat</title><author>Hawranko, Alyssa A. ; Monroe, Philip J. ; Smith, David J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-8af99562479da90d9adaa0b659f83c2689ae1f8ee65cf852ef7848b3e52d1fd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Amino Acid Sequence</topic><topic>Analgesia</topic><topic>Animals</topic><topic>beta-Endorphin - metabolism</topic><topic>Biological and medical sciences</topic><topic>Cytidine Triphosphate - pharmacology</topic><topic>Dizocilpine Maleate</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Heating</topic><topic>Male</topic><topic>Microinjections</topic><topic>Molecular Sequence Data</topic><topic>Morphine</topic><topic>Narcotic Antagonists</topic><topic>Non-opioid</topic><topic>Opioid</topic><topic>Pain - physiopathology</topic><topic>Periaqueductal gray</topic><topic>Periaqueductal Gray - metabolism</topic><topic>Periaqueductal Gray - physiology</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</topic><topic>Stress</topic><topic>Stress, Physiological - metabolism</topic><topic>Stress, Physiological - physiopathology</topic><topic>Synaptic Transmission</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>β-Endorphin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hawranko, Alyssa A.</creatorcontrib><creatorcontrib>Monroe, Philip J.</creatorcontrib><creatorcontrib>Smith, David J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hawranko, Alyssa A.</au><au>Monroe, Philip J.</au><au>Smith, David J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Repetitive exposure to the hot-plate test produces stress induced analgesia and alters β-endorphin neuronal transmission within the periaqueductal gray of the rat</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1994-12-26</date><risdate>1994</risdate><volume>667</volume><issue>2</issue><spage>283</spage><epage>286</epage><pages>283-286</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>Repetitive exposure of rats to a hot plate induced a novel non-opioid form of stress induced analgesia. The exposure caused a persistent 1.5–2 s increase in tail flick latency which was not attenuated by systemic naltrexone, but was completely inhibited by systemic MK-801. Concomitantly, alterations occurred in the ability to pharmacologically distinguish multiple β-endorphin receptors in the periaqueductal gray. Thus, in response to different forms of stress, different pathways may be activated by β-endorphin, resulting in stress induced analgesias with varied pharmacological characteristics (e.g., opioid and non-opioid).</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>7697368</pmid><doi>10.1016/0006-8993(94)91508-3</doi><tpages>4</tpages></addata></record> |
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| subjects | Amino Acid Sequence Analgesia Animals beta-Endorphin - metabolism Biological and medical sciences Cytidine Triphosphate - pharmacology Dizocilpine Maleate Fundamental and applied biological sciences. Psychology Heating Male Microinjections Molecular Sequence Data Morphine Narcotic Antagonists Non-opioid Opioid Pain - physiopathology Periaqueductal gray Periaqueductal Gray - metabolism Periaqueductal Gray - physiology Rat Rats Rats, Sprague-Dawley Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Stress Stress, Physiological - metabolism Stress, Physiological - physiopathology Synaptic Transmission Vertebrates: nervous system and sense organs β-Endorphin |
| title | Repetitive exposure to the hot-plate test produces stress induced analgesia and alters β-endorphin neuronal transmission within the periaqueductal gray of the rat |
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