Postnatal development of the calcium-dependency of glutamate release from rat cortical synaptosomes: comparison with 5-hydroxytryptamine release
The ontogeny of the Ca 2+-dependency of the depolarisation-induced release of preloaded [ 3H]glutamate and [ 3H]5-hydroxytryptamine [5-HT] from rat cortical synaptosomes was examined. 5-HT release was found to be exclusively Ca 2+-dependent at all ages studied. In contrast, glutamate release only sh...
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| Veröffentlicht in: | Brain research. Developmental brain research 1995-10, Vol.89 (1), p.120-123 |
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| container_title | Brain research. Developmental brain research |
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| creator | Jennings, Paul Collard, Keith J. |
| description | The ontogeny of the Ca
2+-dependency of the depolarisation-induced release of preloaded [
3H]glutamate and [
3H]5-hydroxytryptamine [5-HT] from rat cortical synaptosomes was examined. 5-HT release was found to be exclusively Ca
2+-dependent at all ages studied. In contrast, glutamate release only showed a significant Ca
2+-dependent component from postnatal day 10 [PND 10] onwards. This correlated with the ontogeny of the glutamate accumulating activity of synaptic vesicles, a finding consistant with vesicles being the site of Ca
2+-dependent release. The effectiveness of K
+-depolarisation in inducing the Ca
2+-dependent release of both transmitters increased during the early neonatal period, reaching near adult levels at PND20 for 5-HT and PND30 for glutamate. |
| doi_str_mv | 10.1016/0165-3806(95)00107-O |
| format | Article |
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2+-dependency of the depolarisation-induced release of preloaded [
3H]glutamate and [
3H]5-hydroxytryptamine [5-HT] from rat cortical synaptosomes was examined. 5-HT release was found to be exclusively Ca
2+-dependent at all ages studied. In contrast, glutamate release only showed a significant Ca
2+-dependent component from postnatal day 10 [PND 10] onwards. This correlated with the ontogeny of the glutamate accumulating activity of synaptic vesicles, a finding consistant with vesicles being the site of Ca
2+-dependent release. The effectiveness of K
+-depolarisation in inducing the Ca
2+-dependent release of both transmitters increased during the early neonatal period, reaching near adult levels at PND20 for 5-HT and PND30 for glutamate.</description><identifier>ISSN: 0165-3806</identifier><identifier>DOI: 10.1016/0165-3806(95)00107-O</identifier><identifier>PMID: 8575084</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>5-Hydroxytryptamine ; Animals ; Calcium - pharmacology ; Cerebral Cortex - drug effects ; Cerebral Cortex - physiology ; Cerebral Cortex - ultrastructure ; Developmental ; Glutamate ; Glutamic Acid - metabolism ; Membrane Potentials - drug effects ; Potassium - pharmacology ; Rats ; Rats, Wistar ; Release ; Serotonin - metabolism ; Synaptosome ; Synaptosomes - drug effects ; Synaptosomes - metabolism</subject><ispartof>Brain research. Developmental brain research, 1995-10, Vol.89 (1), p.120-123</ispartof><rights>1995</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c337t-1833ab7e3aa155ece886616d07dc6263d76ccdaae9f8c93567808eeabaee8ad83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8575084$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jennings, Paul</creatorcontrib><creatorcontrib>Collard, Keith J.</creatorcontrib><title>Postnatal development of the calcium-dependency of glutamate release from rat cortical synaptosomes: comparison with 5-hydroxytryptamine release</title><title>Brain research. Developmental brain research</title><addtitle>Brain Res Dev Brain Res</addtitle><description>The ontogeny of the Ca
2+-dependency of the depolarisation-induced release of preloaded [
3H]glutamate and [
3H]5-hydroxytryptamine [5-HT] from rat cortical synaptosomes was examined. 5-HT release was found to be exclusively Ca
2+-dependent at all ages studied. In contrast, glutamate release only showed a significant Ca
2+-dependent component from postnatal day 10 [PND 10] onwards. This correlated with the ontogeny of the glutamate accumulating activity of synaptic vesicles, a finding consistant with vesicles being the site of Ca
2+-dependent release. The effectiveness of K
+-depolarisation in inducing the Ca
2+-dependent release of both transmitters increased during the early neonatal period, reaching near adult levels at PND20 for 5-HT and PND30 for glutamate.</description><subject>5-Hydroxytryptamine</subject><subject>Animals</subject><subject>Calcium - pharmacology</subject><subject>Cerebral Cortex - drug effects</subject><subject>Cerebral Cortex - physiology</subject><subject>Cerebral Cortex - ultrastructure</subject><subject>Developmental</subject><subject>Glutamate</subject><subject>Glutamic Acid - metabolism</subject><subject>Membrane Potentials - drug effects</subject><subject>Potassium - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Release</subject><subject>Serotonin - metabolism</subject><subject>Synaptosome</subject><subject>Synaptosomes - drug effects</subject><subject>Synaptosomes - metabolism</subject><issn>0165-3806</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAQx30AlVJ4A5B8QnAI2Ov1RzggoQpapErbQ3u2Zu0Ja5TEwXYKeYs-Ml52tUc4jEaa_4cl_wh5xdl7zrj6UEc2wjD1tpXvGONMN5sn5Px0fkae5_yDVUUYfkbOjNSSmfU5ebyNuYxQoKceH7CP04BjobGjZYfUQe_CPDQeJxw9jm7ZK9_7ucAABWnCHiEj7VIcaIJCXUwl1BTNywhTiTkOmD_W8zBBCjmO9FcoOyqb3eJT_L2UtEy1K4ynrhfkaQd9xpfHfUHuv365u7xubjZX3y4_3zROCF0aboSArUYBwKVEh8YoxZVn2ju1UsJr5ZwHwLYzrhVSacMMImwB0YA34oK8OfROKf6cMRc7hOyw72HEOGertW5XK93-18g1Y4avV9W4Phhdijkn7OyUwgBpsZzZPSW7x2H3OGwr7V9KdlNjr4_983ZAfwodEVX900HH-hsPAZPNLlQU6ENCV6yP4d8P_AEKxahd</recordid><startdate>19951027</startdate><enddate>19951027</enddate><creator>Jennings, Paul</creator><creator>Collard, Keith J.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19951027</creationdate><title>Postnatal development of the calcium-dependency of glutamate release from rat cortical synaptosomes: comparison with 5-hydroxytryptamine release</title><author>Jennings, Paul ; Collard, Keith J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-1833ab7e3aa155ece886616d07dc6263d76ccdaae9f8c93567808eeabaee8ad83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>5-Hydroxytryptamine</topic><topic>Animals</topic><topic>Calcium - pharmacology</topic><topic>Cerebral Cortex - drug effects</topic><topic>Cerebral Cortex - physiology</topic><topic>Cerebral Cortex - ultrastructure</topic><topic>Developmental</topic><topic>Glutamate</topic><topic>Glutamic Acid - metabolism</topic><topic>Membrane Potentials - drug effects</topic><topic>Potassium - pharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Release</topic><topic>Serotonin - metabolism</topic><topic>Synaptosome</topic><topic>Synaptosomes - drug effects</topic><topic>Synaptosomes - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jennings, Paul</creatorcontrib><creatorcontrib>Collard, Keith J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research. Developmental brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jennings, Paul</au><au>Collard, Keith J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Postnatal development of the calcium-dependency of glutamate release from rat cortical synaptosomes: comparison with 5-hydroxytryptamine release</atitle><jtitle>Brain research. Developmental brain research</jtitle><addtitle>Brain Res Dev Brain Res</addtitle><date>1995-10-27</date><risdate>1995</risdate><volume>89</volume><issue>1</issue><spage>120</spage><epage>123</epage><pages>120-123</pages><issn>0165-3806</issn><abstract>The ontogeny of the Ca
2+-dependency of the depolarisation-induced release of preloaded [
3H]glutamate and [
3H]5-hydroxytryptamine [5-HT] from rat cortical synaptosomes was examined. 5-HT release was found to be exclusively Ca
2+-dependent at all ages studied. In contrast, glutamate release only showed a significant Ca
2+-dependent component from postnatal day 10 [PND 10] onwards. This correlated with the ontogeny of the glutamate accumulating activity of synaptic vesicles, a finding consistant with vesicles being the site of Ca
2+-dependent release. The effectiveness of K
+-depolarisation in inducing the Ca
2+-dependent release of both transmitters increased during the early neonatal period, reaching near adult levels at PND20 for 5-HT and PND30 for glutamate.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>8575084</pmid><doi>10.1016/0165-3806(95)00107-O</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0165-3806 |
| ispartof | Brain research. Developmental brain research, 1995-10, Vol.89 (1), p.120-123 |
| issn | 0165-3806 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77792279 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | 5-Hydroxytryptamine Animals Calcium - pharmacology Cerebral Cortex - drug effects Cerebral Cortex - physiology Cerebral Cortex - ultrastructure Developmental Glutamate Glutamic Acid - metabolism Membrane Potentials - drug effects Potassium - pharmacology Rats Rats, Wistar Release Serotonin - metabolism Synaptosome Synaptosomes - drug effects Synaptosomes - metabolism |
| title | Postnatal development of the calcium-dependency of glutamate release from rat cortical synaptosomes: comparison with 5-hydroxytryptamine release |
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