Expression of monovalent and bivalent antibody fragments in Escherichia coli

The technology of humanization of rodent antibodies has opened the way for a broad range of therapeutic antibodies with very low immunogenicity, which are, therefore, suitable for repeated dosing. Such intact antibodies have extended serum half-lives and biodistribution profiles very similar to huma...

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Veröffentlicht in:	Journal of hematotherapy 1995-10, Vol.4 (5), p.383-388
Hauptverfasser:	Grant, S D, Cupit, P M, Learmonth, D, Byrne, F R, Graham, B M, Porter, A J, Harris, W J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibody Affinity Chromatography, Affinity Chromatography, High Pressure Liquid Enzyme-Linked Immunosorbent Assay Escherichia coli - metabolism Humans Immunoglobulin Constant Regions - chemistry Immunoglobulin Constant Regions - genetics Immunoglobulin Fragments - biosynthesis Immunoglobulin Fragments - chemistry Immunoglobulin Fragments - genetics Immunoglobulin Fragments - isolation & purification Mice Protein Conformation Recombinant Fusion Proteins - biosynthesis Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - isolation & purification
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