The role of natural killer cells in immune surveillance of cancer

The role of natural killer cells in immune surveillance of cancer

In the past year, a subset of natural killer cells designated ‘A-NK cells’ has been characterized. These immune cells appear to be able to enter solid tissues, migrate to sites of metastasis and eliminate malignant tissue cells, but spare normal tissue cells. They appear to be ideal surveillance cel...

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Veröffentlicht in:Current opinion in immunology 1995-10, Vol.7 (5), p.704-710
Hauptverfasser: Whiteside, Theresa L, Herberman, Ronald B
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Humans
Killer Cells, Natural - immunology
Killer Cells, Natural - pathology
Lymphocyte Activation
Neoplasms - immunology
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Zusammenfassung:In the past year, a subset of natural killer cells designated ‘A-NK cells’ has been characterized. These immune cells appear to be able to enter solid tissues, migrate to sites of metastasis and eliminate malignant tissue cells, but spare normal tissue cells. They appear to be ideal surveillance cells, readily capable of upregulating antitumor functions in response to local activation signals.
ISSN:0952-7915
1879-0372
DOI:10.1016/0952-7915(95)80080-8