Inhibition of Acyl-CoA: Cholesterol Acyltransferase by Isohalobacillin, a Complex of Novel Cyclic Acylpeptides Produced by Bacillus sp. A1238

A complex of metabolites consisting of two isomeric cyclic acylpeptides was isolated from a culture of Bacillus sp. A1238 by successive chromatographies on Amberlite XAD-7, silica gel and silica ODS columns. By a combination of spectroscopic and chemical analyses, the two subcomponents were identifi...

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Veröffentlicht in:	Journal of antibiotics 1995/12/25, Vol.48(12), pp.1419-1424
Hauptverfasser:	HASUMI, KEIJI, TAKIZAWA, KAZUYUKI, TAKAHASHI, FUMIHITO, PARK, JONG Koo, ENDO, AKIRA
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Bacillus Bacillus - metabolism Biological and medical sciences Cell-Free System Cholesterol Esters - metabolism Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology General and cellular metabolism. Vitamins Lipoproteins - metabolism Macrophages - drug effects Macrophages - metabolism Medical sciences Microsomes, Liver - drug effects Microsomes, Liver - enzymology Molecular Sequence Data Molecular Structure Peptides, Cyclic - chemistry Peptides, Cyclic - pharmacology Pharmacology. Drug treatments Rats Spectrum Analysis Sterol O-Acyltransferase - antagonists & inhibitors
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