Drug mixture which improves survival of ischemic rabbit epigastric skin flaps
The chief aim of this study was to maximize flap survival by counteracting the pathophysiological changes occurring during ischemia‐reperfusion. Rabbit epigastric skin flaps given 21 hours of ischemia were infused intra‐arterially with selected drugs at the start of reperfusion. Compared with contro...
Gespeichert in:
| Veröffentlicht in: | Microsurgery 1994, Vol.15 (10), p.685-692 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 692 |
|---|---|
| container_issue | 10 |
| container_start_page | 685 |
| container_title | Microsurgery |
| container_volume | 15 |
| creator | Lepore, Diana A. Knight, Kenneth R. Bhattacharya, Surajit Ritz, Morris Robbins, Sonia P. Sieg, Peter Morrison, Wayne A. O'Brien, Bernard McC |
| description | The chief aim of this study was to maximize flap survival by counteracting the pathophysiological changes occurring during ischemia‐reperfusion. Rabbit epigastric skin flaps given 21 hours of ischemia were infused intra‐arterially with selected drugs at the start of reperfusion. Compared with control infused ischemic flaps, which had a 33% survival rate on day 7 post‐ischemia, significant improvement was found with vasodilators nitrendipine (61%) and prostacyclin (65%) and the thrombolytic agent urokinase (65%); marginal improvement with the free radical scavenger desferrioxamine (53%); but no change with streptokinase (44%), heparin (21%), and ATP‐MgCl2 (35%). A drug mixture comprising all of these agents except streptokinase and urokinase produced 87% survival, suggesting an additive effect. Biochemical assays on skin homogenates and blood implicated oxygen free radicals, neutrophil infiltration, and thromboxane in flap failure. These results imply that multiple factors are responsible for ischemic flap failure and that a mixture of drugs needs to be infused to counteract all of the detrimental changes. © 1994 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/micr.1920151005 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_77788887</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>77788887</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4135-b32be0ae87ef15be604ab40d0d2a52abc49909494754d91bc96e166a51af81a23</originalsourceid><addsrcrecordid>eNqFUE1PGzEQtVARDbRnTpV86m1hbK_XtnqqwqcUQKKQHi17M0tcdkmwdwP8e4wSUXFiLqOZee_N0yNkn8EBA-CHXajjATMcmMyz3CIjBkYXXEn-hYxACV0w0PIr2U3pHwAYo8wO2VFSCK3kiFwcxeGOduG5HyLSp3mo5zR0y7hYYaJpiKuwci1dNDSkeo75G43O-9BTXIY7l_qYN-k-PNCmdcv0jWw3rk34fdP3yO3J8c34rJhcnZ6Pf0-KumRCFl5wj-BQK2yY9FhB6XwJM5hxJ7nzdWkMmNKUSpYzw3xtKmRV5SRzjWaOiz3yc62bjT4OmHrbZX_Ytu4BF0OySimdS30K5IxrUExn4OEaWMdFShEbu4yhc_HFMrBvSdu3pO3_pDPjx0Z68B3O3vGbaPP91_r-FFp8-UzOXpyPrz-oF2t2SD0-v7NdvLeVEkrav5endvpnWk4up8JW4hWqT5rA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>21280718</pqid></control><display><type>article</type><title>Drug mixture which improves survival of ischemic rabbit epigastric skin flaps</title><source>MEDLINE</source><source>Wiley Online Library</source><creator>Lepore, Diana A. ; Knight, Kenneth R. ; Bhattacharya, Surajit ; Ritz, Morris ; Robbins, Sonia P. ; Sieg, Peter ; Morrison, Wayne A. ; O'Brien, Bernard McC</creator><creatorcontrib>Lepore, Diana A. ; Knight, Kenneth R. ; Bhattacharya, Surajit ; Ritz, Morris ; Robbins, Sonia P. ; Sieg, Peter ; Morrison, Wayne A. ; O'Brien, Bernard McC</creatorcontrib><description>The chief aim of this study was to maximize flap survival by counteracting the pathophysiological changes occurring during ischemia‐reperfusion. Rabbit epigastric skin flaps given 21 hours of ischemia were infused intra‐arterially with selected drugs at the start of reperfusion. Compared with control infused ischemic flaps, which had a 33% survival rate on day 7 post‐ischemia, significant improvement was found with vasodilators nitrendipine (61%) and prostacyclin (65%) and the thrombolytic agent urokinase (65%); marginal improvement with the free radical scavenger desferrioxamine (53%); but no change with streptokinase (44%), heparin (21%), and ATP‐MgCl2 (35%). A drug mixture comprising all of these agents except streptokinase and urokinase produced 87% survival, suggesting an additive effect. Biochemical assays on skin homogenates and blood implicated oxygen free radicals, neutrophil infiltration, and thromboxane in flap failure. These results imply that multiple factors are responsible for ischemic flap failure and that a mixture of drugs needs to be infused to counteract all of the detrimental changes. © 1994 Wiley‐Liss, Inc.</description><identifier>ISSN: 0738-1085</identifier><identifier>EISSN: 1098-2752</identifier><identifier>DOI: 10.1002/micr.1920151005</identifier><identifier>PMID: 7533875</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject><![CDATA[Adenosine Triphosphate - administration & dosage ; Animals ; Deferoxamine - administration & dosage ; Dextrans - administration & dosage ; Drug Combinations ; Epoprostenol - administration & dosage ; Heparin - administration & dosage ; Infusions, Intra-Arterial ; Nitrendipine - administration & dosage ; Rabbits ; Reperfusion Injury - drug therapy ; Streptokinase - administration & dosage ; Surgical Flaps ; Urokinase-Type Plasminogen Activator - administration & dosage ; Vasodilator Agents - therapeutic use]]></subject><ispartof>Microsurgery, 1994, Vol.15 (10), p.685-692</ispartof><rights>Copyright © 1994 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4135-b32be0ae87ef15be604ab40d0d2a52abc49909494754d91bc96e166a51af81a23</citedby><cites>FETCH-LOGICAL-c4135-b32be0ae87ef15be604ab40d0d2a52abc49909494754d91bc96e166a51af81a23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmicr.1920151005$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmicr.1920151005$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,4009,27902,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7533875$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lepore, Diana A.</creatorcontrib><creatorcontrib>Knight, Kenneth R.</creatorcontrib><creatorcontrib>Bhattacharya, Surajit</creatorcontrib><creatorcontrib>Ritz, Morris</creatorcontrib><creatorcontrib>Robbins, Sonia P.</creatorcontrib><creatorcontrib>Sieg, Peter</creatorcontrib><creatorcontrib>Morrison, Wayne A.</creatorcontrib><creatorcontrib>O'Brien, Bernard McC</creatorcontrib><title>Drug mixture which improves survival of ischemic rabbit epigastric skin flaps</title><title>Microsurgery</title><addtitle>Microsurgery</addtitle><description>The chief aim of this study was to maximize flap survival by counteracting the pathophysiological changes occurring during ischemia‐reperfusion. Rabbit epigastric skin flaps given 21 hours of ischemia were infused intra‐arterially with selected drugs at the start of reperfusion. Compared with control infused ischemic flaps, which had a 33% survival rate on day 7 post‐ischemia, significant improvement was found with vasodilators nitrendipine (61%) and prostacyclin (65%) and the thrombolytic agent urokinase (65%); marginal improvement with the free radical scavenger desferrioxamine (53%); but no change with streptokinase (44%), heparin (21%), and ATP‐MgCl2 (35%). A drug mixture comprising all of these agents except streptokinase and urokinase produced 87% survival, suggesting an additive effect. Biochemical assays on skin homogenates and blood implicated oxygen free radicals, neutrophil infiltration, and thromboxane in flap failure. These results imply that multiple factors are responsible for ischemic flap failure and that a mixture of drugs needs to be infused to counteract all of the detrimental changes. © 1994 Wiley‐Liss, Inc.</description><subject>Adenosine Triphosphate - administration & dosage</subject><subject>Animals</subject><subject>Deferoxamine - administration & dosage</subject><subject>Dextrans - administration & dosage</subject><subject>Drug Combinations</subject><subject>Epoprostenol - administration & dosage</subject><subject>Heparin - administration & dosage</subject><subject>Infusions, Intra-Arterial</subject><subject>Nitrendipine - administration & dosage</subject><subject>Rabbits</subject><subject>Reperfusion Injury - drug therapy</subject><subject>Streptokinase - administration & dosage</subject><subject>Surgical Flaps</subject><subject>Urokinase-Type Plasminogen Activator - administration & dosage</subject><subject>Vasodilator Agents - therapeutic use</subject><issn>0738-1085</issn><issn>1098-2752</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUE1PGzEQtVARDbRnTpV86m1hbK_XtnqqwqcUQKKQHi17M0tcdkmwdwP8e4wSUXFiLqOZee_N0yNkn8EBA-CHXajjATMcmMyz3CIjBkYXXEn-hYxACV0w0PIr2U3pHwAYo8wO2VFSCK3kiFwcxeGOduG5HyLSp3mo5zR0y7hYYaJpiKuwci1dNDSkeo75G43O-9BTXIY7l_qYN-k-PNCmdcv0jWw3rk34fdP3yO3J8c34rJhcnZ6Pf0-KumRCFl5wj-BQK2yY9FhB6XwJM5hxJ7nzdWkMmNKUSpYzw3xtKmRV5SRzjWaOiz3yc62bjT4OmHrbZX_Ytu4BF0OySimdS30K5IxrUExn4OEaWMdFShEbu4yhc_HFMrBvSdu3pO3_pDPjx0Z68B3O3vGbaPP91_r-FFp8-UzOXpyPrz-oF2t2SD0-v7NdvLeVEkrav5endvpnWk4up8JW4hWqT5rA</recordid><startdate>1994</startdate><enddate>1994</enddate><creator>Lepore, Diana A.</creator><creator>Knight, Kenneth R.</creator><creator>Bhattacharya, Surajit</creator><creator>Ritz, Morris</creator><creator>Robbins, Sonia P.</creator><creator>Sieg, Peter</creator><creator>Morrison, Wayne A.</creator><creator>O'Brien, Bernard McC</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>1994</creationdate><title>Drug mixture which improves survival of ischemic rabbit epigastric skin flaps</title><author>Lepore, Diana A. ; Knight, Kenneth R. ; Bhattacharya, Surajit ; Ritz, Morris ; Robbins, Sonia P. ; Sieg, Peter ; Morrison, Wayne A. ; O'Brien, Bernard McC</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4135-b32be0ae87ef15be604ab40d0d2a52abc49909494754d91bc96e166a51af81a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Adenosine Triphosphate - administration & dosage</topic><topic>Animals</topic><topic>Deferoxamine - administration & dosage</topic><topic>Dextrans - administration & dosage</topic><topic>Drug Combinations</topic><topic>Epoprostenol - administration & dosage</topic><topic>Heparin - administration & dosage</topic><topic>Infusions, Intra-Arterial</topic><topic>Nitrendipine - administration & dosage</topic><topic>Rabbits</topic><topic>Reperfusion Injury - drug therapy</topic><topic>Streptokinase - administration & dosage</topic><topic>Surgical Flaps</topic><topic>Urokinase-Type Plasminogen Activator - administration & dosage</topic><topic>Vasodilator Agents - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lepore, Diana A.</creatorcontrib><creatorcontrib>Knight, Kenneth R.</creatorcontrib><creatorcontrib>Bhattacharya, Surajit</creatorcontrib><creatorcontrib>Ritz, Morris</creatorcontrib><creatorcontrib>Robbins, Sonia P.</creatorcontrib><creatorcontrib>Sieg, Peter</creatorcontrib><creatorcontrib>Morrison, Wayne A.</creatorcontrib><creatorcontrib>O'Brien, Bernard McC</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Microsurgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lepore, Diana A.</au><au>Knight, Kenneth R.</au><au>Bhattacharya, Surajit</au><au>Ritz, Morris</au><au>Robbins, Sonia P.</au><au>Sieg, Peter</au><au>Morrison, Wayne A.</au><au>O'Brien, Bernard McC</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Drug mixture which improves survival of ischemic rabbit epigastric skin flaps</atitle><jtitle>Microsurgery</jtitle><addtitle>Microsurgery</addtitle><date>1994</date><risdate>1994</risdate><volume>15</volume><issue>10</issue><spage>685</spage><epage>692</epage><pages>685-692</pages><issn>0738-1085</issn><eissn>1098-2752</eissn><abstract>The chief aim of this study was to maximize flap survival by counteracting the pathophysiological changes occurring during ischemia‐reperfusion. Rabbit epigastric skin flaps given 21 hours of ischemia were infused intra‐arterially with selected drugs at the start of reperfusion. Compared with control infused ischemic flaps, which had a 33% survival rate on day 7 post‐ischemia, significant improvement was found with vasodilators nitrendipine (61%) and prostacyclin (65%) and the thrombolytic agent urokinase (65%); marginal improvement with the free radical scavenger desferrioxamine (53%); but no change with streptokinase (44%), heparin (21%), and ATP‐MgCl2 (35%). A drug mixture comprising all of these agents except streptokinase and urokinase produced 87% survival, suggesting an additive effect. Biochemical assays on skin homogenates and blood implicated oxygen free radicals, neutrophil infiltration, and thromboxane in flap failure. These results imply that multiple factors are responsible for ischemic flap failure and that a mixture of drugs needs to be infused to counteract all of the detrimental changes. © 1994 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>7533875</pmid><doi>10.1002/micr.1920151005</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0738-1085 |
| ispartof | Microsurgery, 1994, Vol.15 (10), p.685-692 |
| issn | 0738-1085 1098-2752 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77788887 |
| source | MEDLINE; Wiley Online Library |
| subjects | Adenosine Triphosphate - administration & dosage Animals Deferoxamine - administration & dosage Dextrans - administration & dosage Drug Combinations Epoprostenol - administration & dosage Heparin - administration & dosage Infusions, Intra-Arterial Nitrendipine - administration & dosage Rabbits Reperfusion Injury - drug therapy Streptokinase - administration & dosage Surgical Flaps Urokinase-Type Plasminogen Activator - administration & dosage Vasodilator Agents - therapeutic use |
| title | Drug mixture which improves survival of ischemic rabbit epigastric skin flaps |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T17%3A17%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Drug%20mixture%20which%20improves%20survival%20of%20ischemic%20rabbit%20epigastric%20skin%20flaps&rft.jtitle=Microsurgery&rft.au=Lepore,%20Diana%20A.&rft.date=1994&rft.volume=15&rft.issue=10&rft.spage=685&rft.epage=692&rft.pages=685-692&rft.issn=0738-1085&rft.eissn=1098-2752&rft_id=info:doi/10.1002/micr.1920151005&rft_dat=%3Cproquest_cross%3E77788887%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=21280718&rft_id=info:pmid/7533875&rfr_iscdi=true |