Alternatives to allogeneic blood use in surgery: Acute normovolemic hemodilution and preoperative autologous donation

Acute normovolemic hemodilution (ANH) is a common blood conservation strategy in elective surgical procedures. Moderate ANH is safe in patients >60 years of age; ANH is not recommended for patients who have coronary artery disease, significant anemia, renal disease, severe hepatic disease, pulmon...

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Veröffentlicht in:The American journal of surgery 1995-12, Vol.170 (6), p.S49-S52
Hauptverfasser: D'Ambra, Michael N., Kaplan, David K.
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container_title The American journal of surgery
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creator D'Ambra, Michael N.
Kaplan, David K.
description Acute normovolemic hemodilution (ANH) is a common blood conservation strategy in elective surgical procedures. Moderate ANH is safe in patients >60 years of age; ANH is not recommended for patients who have coronary artery disease, significant anemia, renal disease, severe hepatic disease, pulmonary emphysema, or obstructive lung disease. Preservation of oxygen delivery during ANH depends on the maintenance of normovolemia to avoid decompensation and falling cardiac output. Preoperative autologous donation (PAD) as a blood conservation strategy has the advantage of protecting the patient from risks associated with allogenic transfusion, but it is expensive and time consuming. No protocols have established a preference for either ANH or PAD; an early study suggested that ANH is less expensive and more effectively preserves blood components, but other researchers warn that the methodology for ANH remains unresolved.
doi_str_mv 10.1016/S0002-9610(99)80059-2
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subjects Aged
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Blood Transfusion - methods
Blood Transfusion, Autologous
Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis
Cardiac Surgical Procedures
Hemodilution - methods
Humans
Medical sciences
Preoperative Care - methods
Transfusions. Complications. Transfusion reactions. Cell and gene therapy
title Alternatives to allogeneic blood use in surgery: Acute normovolemic hemodilution and preoperative autologous donation
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