NO synthase, and free radical generation in brain regions of old rats: correlations with individual behaviour
WE have investigated the activity of NO synthase (NOS), and generation of free radicals (FRG) in selected brain regions of old male Wistar rats. Using the emotional resonance test, two groups of rats were selected for the experimentpassive, preferring dark space, and active, preferring light space....
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| Veröffentlicht in: | Neuroreport 1994-12, Vol.6 (1), p.94-96 |
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| creator | Gulyaeva, Natalia V Onufriev, Mikhail V Stepanichev, Mikhail Yu |
| description | WE have investigated the activity of NO synthase (NOS), and generation of free radicals (FRG) in selected brain regions of old male Wistar rats. Using the emotional resonance test, two groups of rats were selected for the experimentpassive, preferring dark space, and active, preferring light space. Highest NOS activity, and FRG were seen in cerebellum. As a rule, NOS activity was lower, and FRG higher in the respective brain regions of active rats than in passive rats. Positive linear inter-regional cross-correlations of NOS activity as well as of FRG were found. When all rats were assessed as one group, negative correlations between NOS, and FRG in cerebral cortex were revealed. |
| doi_str_mv | 10.1097/00001756-199412300-00025 |
| format | Article |
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When all rats were assessed as one group, negative correlations between NOS, and FRG in cerebral cortex were revealed.</description><subject>Aging - metabolism</subject><subject>Amino Acid Oxidoreductases - metabolism</subject><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Behavior, Animal - physiology</subject><subject>Brain - metabolism</subject><subject>Male</subject><subject>Nitric Oxide Synthase</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Tissue Distribution</subject><issn>0959-4965</issn><issn>1473-558X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v3CAQhlGVKtls-xMqceopTsGAgd6iVT4qrZpLIvWGsD2saViTgJ1V_n1JdptbVQ6gYZ535vAghCk5p0TLb6QcKkVTUa05rRkhVfmpxQe0oFyySgj16wgtiBa64roRJ-g0598F0YSqY3QsBRNC6gXa_rzF-WWcBpvhDNuxxy4B4GR739mANzBCspOPI_YjbpMtd4JNqTOODsfQF3TK33EXU4LwRma889NQ-N4_-34uU1oY7LOPc_qEPjobMnw-vEt0f3V5t7qp1rfXP1YX66pjjIpKMdVAqx20pJWqdkQJ1TtFqANrG1c76JTT1PZWOatYzWtdS665VEzyjmu2RF_3cx9TfJohT2brcwch2BHinI2UUjVcyf-CtJGUNfQVVHuwSzHnBM48Jr-16cVQYl6VmL9KzLsS86akRL8cdsztFvr34MFB6fN9fxfDBCk_hHkHyQxgwzSYf5lmfwBjhJdg</recordid><startdate>19941230</startdate><enddate>19941230</enddate><creator>Gulyaeva, Natalia V</creator><creator>Onufriev, Mikhail V</creator><creator>Stepanichev, Mikhail Yu</creator><general>Lippincott-Raven Publishers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19941230</creationdate><title>NO synthase, and free radical generation in brain regions of old rats: correlations with individual behaviour</title><author>Gulyaeva, Natalia V ; Onufriev, Mikhail V ; Stepanichev, Mikhail Yu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3315-8386eb9feb0b782f0858df801feaa6f2fec8f91ada8fa8324292749478374c493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Aging - metabolism</topic><topic>Amino Acid Oxidoreductases - metabolism</topic><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Behavior, Animal - physiology</topic><topic>Brain - metabolism</topic><topic>Male</topic><topic>Nitric Oxide Synthase</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Tissue Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gulyaeva, Natalia V</creatorcontrib><creatorcontrib>Onufriev, Mikhail V</creatorcontrib><creatorcontrib>Stepanichev, Mikhail Yu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroreport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gulyaeva, Natalia V</au><au>Onufriev, Mikhail V</au><au>Stepanichev, Mikhail Yu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>NO synthase, and free radical generation in brain regions of old rats: correlations with individual behaviour</atitle><jtitle>Neuroreport</jtitle><addtitle>Neuroreport</addtitle><date>1994-12-30</date><risdate>1994</risdate><volume>6</volume><issue>1</issue><spage>94</spage><epage>96</epage><pages>94-96</pages><issn>0959-4965</issn><eissn>1473-558X</eissn><abstract>WE have investigated the activity of NO synthase (NOS), and generation of free radicals (FRG) in selected brain regions of old male Wistar rats. 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| ispartof | Neuroreport, 1994-12, Vol.6 (1), p.94-96 |
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| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Aging - metabolism Amino Acid Oxidoreductases - metabolism Analysis of Variance Animals Behavior, Animal - physiology Brain - metabolism Male Nitric Oxide Synthase Rats Rats, Wistar Reactive Oxygen Species - metabolism Tissue Distribution |
| title | NO synthase, and free radical generation in brain regions of old rats: correlations with individual behaviour |
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