Localization and Physical Mapping of the Prostate-Specific Membrane Antigen (PSM) Gene to Human Chromosome 11
The prostate-specific membrane antigen (PSM) was identified by the monoclonal antibody 7E11-C5.3, which was raised against the human prostatic carcinoma cell line LNCaP (3). The PSM antigen is expressed by normal, neoplastic, and metastatic prostatic tissues. The 2.65-kb cDNA encoding the 100-kDa PS...
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| Veröffentlicht in: | Genomics 1995-11, Vol.30 (1), p.105-108 |
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| creator | RINKER-SCHAEFFER, CARRIE W. HAWKINS, ANITA L. SU, SAI L. ISRAELI, RON S. GRIFFIN, CONSTANCE A. ISAACS, JOHN T. HESTON, WARREN D.W. |
| description | The prostate-specific membrane antigen (PSM) was identified by the monoclonal antibody 7E11-C5.3, which was raised against the human prostatic carcinoma cell line LNCaP (3). The PSM antigen is expressed by normal, neoplastic, and metastatic prostatic tissues. The 2.65-kb cDNA encoding the 100-kDa PSM glycoprotein was cloned from LNCaP cells (4). Studies have shown that the expression of PSM is tissue-specific (5). In the present study monochromosomal somatic cell hybrids were used to localize the PSM gene to human chromosome 11. Using this information, initial mapping studies identified two potential PSM gene loci at 11p11.1–p13 and 11q14. Further high-stringency analysis using cosmid probes identified the 11q14 region as the location of the PSM gene. |
| doi_str_mv | 10.1006/geno.1995.0019 |
| format | Article |
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The PSM antigen is expressed by normal, neoplastic, and metastatic prostatic tissues. The 2.65-kb cDNA encoding the 100-kDa PSM glycoprotein was cloned from LNCaP cells (4). Studies have shown that the expression of PSM is tissue-specific (5). In the present study monochromosomal somatic cell hybrids were used to localize the PSM gene to human chromosome 11. Using this information, initial mapping studies identified two potential PSM gene loci at 11p11.1–p13 and 11q14. Further high-stringency analysis using cosmid probes identified the 11q14 region as the location of the PSM gene.</description><identifier>ISSN: 0888-7543</identifier><identifier>EISSN: 1089-8646</identifier><identifier>DOI: 10.1006/geno.1995.0019</identifier><identifier>PMID: 8595888</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>ANTIGENS ; Antigens, Neoplasm - genetics ; Antigens, Surface - genetics ; Biological and medical sciences ; BIOLOGICAL MARKERS ; BIOLOGY AND MEDICINE, BASIC STUDIES ; Blotting, Southern ; CARCINOMAS ; Chromosome Mapping - methods ; Chromosomes, Human, Pair 11 ; Classical genetics, quantitative genetics, hybrids ; DIAGNOSIS ; DNA HYBRIDIZATION ; DNA-CLONING ; FLUORESCENCE ; Fundamental and applied biological sciences. Psychology ; GENE REGULATION ; GENES ; GENETIC MAPPING ; Genetics of eukaryotes. Biological and molecular evolution ; Glutamate Carboxypeptidase II ; Human ; HUMAN CHROMOSOMES ; Humans ; Hybrid Cells ; HYBRIDIZATION ; In Situ Hybridization, Fluorescence - methods ; Male ; PROBES ; PROSTATE ; SOMATIC CELLS ; TISSUE DISTRIBUTION</subject><ispartof>Genomics, 1995-11, Vol.30 (1), p.105-108</ispartof><rights>1995</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c529t-ba337b0b6a77dc9271b26778c013b08bc54587c983e8686d904435924fb49f283</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1006/geno.1995.0019$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,886,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2914278$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8595888$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/273472$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>RINKER-SCHAEFFER, CARRIE W.</creatorcontrib><creatorcontrib>HAWKINS, ANITA L.</creatorcontrib><creatorcontrib>SU, SAI L.</creatorcontrib><creatorcontrib>ISRAELI, RON S.</creatorcontrib><creatorcontrib>GRIFFIN, CONSTANCE A.</creatorcontrib><creatorcontrib>ISAACS, JOHN T.</creatorcontrib><creatorcontrib>HESTON, WARREN D.W.</creatorcontrib><title>Localization and Physical Mapping of the Prostate-Specific Membrane Antigen (PSM) Gene to Human Chromosome 11</title><title>Genomics</title><addtitle>Genomics</addtitle><description>The prostate-specific membrane antigen (PSM) was identified by the monoclonal antibody 7E11-C5.3, which was raised against the human prostatic carcinoma cell line LNCaP (3). The PSM antigen is expressed by normal, neoplastic, and metastatic prostatic tissues. The 2.65-kb cDNA encoding the 100-kDa PSM glycoprotein was cloned from LNCaP cells (4). Studies have shown that the expression of PSM is tissue-specific (5). In the present study monochromosomal somatic cell hybrids were used to localize the PSM gene to human chromosome 11. Using this information, initial mapping studies identified two potential PSM gene loci at 11p11.1–p13 and 11q14. Further high-stringency analysis using cosmid probes identified the 11q14 region as the location of the PSM gene.</description><subject>ANTIGENS</subject><subject>Antigens, Neoplasm - genetics</subject><subject>Antigens, Surface - genetics</subject><subject>Biological and medical sciences</subject><subject>BIOLOGICAL MARKERS</subject><subject>BIOLOGY AND MEDICINE, BASIC STUDIES</subject><subject>Blotting, Southern</subject><subject>CARCINOMAS</subject><subject>Chromosome Mapping - methods</subject><subject>Chromosomes, Human, Pair 11</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>DIAGNOSIS</subject><subject>DNA HYBRIDIZATION</subject><subject>DNA-CLONING</subject><subject>FLUORESCENCE</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GENE REGULATION</subject><subject>GENES</subject><subject>GENETIC MAPPING</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Glutamate Carboxypeptidase II</subject><subject>Human</subject><subject>HUMAN CHROMOSOMES</subject><subject>Humans</subject><subject>Hybrid Cells</subject><subject>HYBRIDIZATION</subject><subject>In Situ Hybridization, Fluorescence - methods</subject><subject>Male</subject><subject>PROBES</subject><subject>PROSTATE</subject><subject>SOMATIC CELLS</subject><subject>TISSUE DISTRIBUTION</subject><issn>0888-7543</issn><issn>1089-8646</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUFrGzEQhUVpSZ00194KKoTQHtaVtNqVdAymTQo2MaQ5C612NlbxSltJLiS_vlpscutJMPPN6M17CH2kZEkJab89gQ9LqlSzJISqN2hBiVSVbHn7Fi2IlLISDa_fo_OUfhNCVC3ZGTqTjWpKb4HGdbBm715MdsFj43u83T0nV2p4Y6bJ-SccBpx3gLcxpGwyVA8TWDc4izcwdtF4wDc-u6IDf9k-bL7iWyilHPDdYTQer3YxjCGFETClH9C7wewTXJ7eC_T44_uv1V21vr_9ubpZV7ZhKledqWvRka41QvRWMUE71gohLaF1R2RnG95IYZWsQbay7RXhvG4U40PH1cBkfYE-H_cWyU4n6zLYnQ3eg82aiZoLVpjrIzPF8OcAKevRJQv7fbkoHJIW5cNGcVHA5RG0xYEUYdBTdKOJz5oSPWeg5wz0nIGeMygDn06bD90I_St-Mr30r059k4rRQ_HQuvSKMUU5EzMmjxgUp_46iPMh4C30Ls539MH9T8E_SqKgaw</recordid><startdate>19951101</startdate><enddate>19951101</enddate><creator>RINKER-SCHAEFFER, CARRIE W.</creator><creator>HAWKINS, ANITA L.</creator><creator>SU, SAI L.</creator><creator>ISRAELI, RON S.</creator><creator>GRIFFIN, CONSTANCE A.</creator><creator>ISAACS, JOHN T.</creator><creator>HESTON, WARREN D.W.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>19951101</creationdate><title>Localization and Physical Mapping of the Prostate-Specific Membrane Antigen (PSM) Gene to Human Chromosome 11</title><author>RINKER-SCHAEFFER, CARRIE W. ; HAWKINS, ANITA L. ; SU, SAI L. ; ISRAELI, RON S. ; GRIFFIN, CONSTANCE A. ; ISAACS, JOHN T. ; HESTON, WARREN D.W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c529t-ba337b0b6a77dc9271b26778c013b08bc54587c983e8686d904435924fb49f283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>ANTIGENS</topic><topic>Antigens, Neoplasm - genetics</topic><topic>Antigens, Surface - genetics</topic><topic>Biological and medical sciences</topic><topic>BIOLOGICAL MARKERS</topic><topic>BIOLOGY AND MEDICINE, BASIC STUDIES</topic><topic>Blotting, Southern</topic><topic>CARCINOMAS</topic><topic>Chromosome Mapping - methods</topic><topic>Chromosomes, Human, Pair 11</topic><topic>Classical genetics, quantitative genetics, hybrids</topic><topic>DIAGNOSIS</topic><topic>DNA HYBRIDIZATION</topic><topic>DNA-CLONING</topic><topic>FLUORESCENCE</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GENE REGULATION</topic><topic>GENES</topic><topic>GENETIC MAPPING</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Glutamate Carboxypeptidase II</topic><topic>Human</topic><topic>HUMAN CHROMOSOMES</topic><topic>Humans</topic><topic>Hybrid Cells</topic><topic>HYBRIDIZATION</topic><topic>In Situ Hybridization, Fluorescence - methods</topic><topic>Male</topic><topic>PROBES</topic><topic>PROSTATE</topic><topic>SOMATIC CELLS</topic><topic>TISSUE DISTRIBUTION</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>RINKER-SCHAEFFER, CARRIE W.</creatorcontrib><creatorcontrib>HAWKINS, ANITA L.</creatorcontrib><creatorcontrib>SU, SAI L.</creatorcontrib><creatorcontrib>ISRAELI, RON S.</creatorcontrib><creatorcontrib>GRIFFIN, CONSTANCE A.</creatorcontrib><creatorcontrib>ISAACS, JOHN T.</creatorcontrib><creatorcontrib>HESTON, WARREN D.W.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Genomics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>RINKER-SCHAEFFER, CARRIE W.</au><au>HAWKINS, ANITA L.</au><au>SU, SAI L.</au><au>ISRAELI, RON S.</au><au>GRIFFIN, CONSTANCE A.</au><au>ISAACS, JOHN T.</au><au>HESTON, WARREN D.W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Localization and Physical Mapping of the Prostate-Specific Membrane Antigen (PSM) Gene to Human Chromosome 11</atitle><jtitle>Genomics</jtitle><addtitle>Genomics</addtitle><date>1995-11-01</date><risdate>1995</risdate><volume>30</volume><issue>1</issue><spage>105</spage><epage>108</epage><pages>105-108</pages><issn>0888-7543</issn><eissn>1089-8646</eissn><abstract>The prostate-specific membrane antigen (PSM) was identified by the monoclonal antibody 7E11-C5.3, which was raised against the human prostatic carcinoma cell line LNCaP (3). The PSM antigen is expressed by normal, neoplastic, and metastatic prostatic tissues. The 2.65-kb cDNA encoding the 100-kDa PSM glycoprotein was cloned from LNCaP cells (4). Studies have shown that the expression of PSM is tissue-specific (5). In the present study monochromosomal somatic cell hybrids were used to localize the PSM gene to human chromosome 11. Using this information, initial mapping studies identified two potential PSM gene loci at 11p11.1–p13 and 11q14. Further high-stringency analysis using cosmid probes identified the 11q14 region as the location of the PSM gene.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>8595888</pmid><doi>10.1006/geno.1995.0019</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | ANTIGENS Antigens, Neoplasm - genetics Antigens, Surface - genetics Biological and medical sciences BIOLOGICAL MARKERS BIOLOGY AND MEDICINE, BASIC STUDIES Blotting, Southern CARCINOMAS Chromosome Mapping - methods Chromosomes, Human, Pair 11 Classical genetics, quantitative genetics, hybrids DIAGNOSIS DNA HYBRIDIZATION DNA-CLONING FLUORESCENCE Fundamental and applied biological sciences. Psychology GENE REGULATION GENES GENETIC MAPPING Genetics of eukaryotes. Biological and molecular evolution Glutamate Carboxypeptidase II Human HUMAN CHROMOSOMES Humans Hybrid Cells HYBRIDIZATION In Situ Hybridization, Fluorescence - methods Male PROBES PROSTATE SOMATIC CELLS TISSUE DISTRIBUTION |
| title | Localization and Physical Mapping of the Prostate-Specific Membrane Antigen (PSM) Gene to Human Chromosome 11 |
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