Catecholaminergic mediation of morphine-induced activation of pituitary-adrenocortical axis in the rat: implication of α- and β-adrenoceptors

The present study investigates the role of hypothalamic catecholamines in the effects of morphine on hypothalamo-pituitary-adrenocortical (HPA) axis. Acutely administered morphine (30 mg/kg i.p) increased plasma corticosterone and reduced the hypothalamic noradrenaline (NA) content but it did not ch...

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Veröffentlicht in:	Brain research 1994-12, Vol.668 (1), p.122-128
Hauptverfasser:	Martinez-Pin˜ero, M. Gloria, Milanés, M. Victoria, Alcaraz, Cristina, Vargas, M. Luisa
Format:	Artikel
Sprache:	eng
Schlagworte:	3,4-Dihydroxyphenylacetic Acid - metabolism Adrenergic alpha-1 Receptor Agonists Adrenergic alpha-2 Receptor Agonists Adrenergic beta-Agonists - pharmacology Adrenergic blocking drug Adrenocorticotropic Hormone - metabolism Animals Biological and medical sciences Catecholamine Corticosterone - blood Corticotropin-Releasing Hormone - metabolism Dopamine - metabolism Fundamental and applied biological sciences. Psychology gamma-Aminobutyric Acid - metabolism Hormones and neuropeptides. Regulation HPA axis Hypothalamo-Hypophyseal System - drug effects Hypothalamo-Hypophyseal System - metabolism Hypothalamus Hypothalamus. Hypophysis. Epiphysis. Urophysis Male Morphine Morphine - pharmacology Norepinephrine - metabolism Pituitary-Adrenal System - drug effects Pituitary-Adrenal System - metabolism Prazosin - pharmacology Rats Rats, Sprague-Dawley Receptors, Adrenergic, alpha-1 - physiology Receptors, Adrenergic, alpha-2 - physiology Reserpine Vertebrates: endocrinology
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