Catecholaminergic mediation of morphine-induced activation of pituitary-adrenocortical axis in the rat: implication of α- and β-adrenoceptors
The present study investigates the role of hypothalamic catecholamines in the effects of morphine on hypothalamo-pituitary-adrenocortical (HPA) axis. Acutely administered morphine (30 mg/kg i.p) increased plasma corticosterone and reduced the hypothalamic noradrenaline (NA) content but it did not ch...
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| Veröffentlicht in: | Brain research 1994-12, Vol.668 (1), p.122-128 |
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| creator | Martinez-Pin˜ero, M. Gloria Milanés, M. Victoria Alcaraz, Cristina Vargas, M. Luisa |
| description | The present study investigates the role of hypothalamic catecholamines in the effects of morphine on hypothalamo-pituitary-adrenocortical (HPA) axis. Acutely administered morphine (30 mg/kg i.p) increased plasma corticosterone and reduced the hypothalamic noradrenaline (NA) content but it did not change either the dopamine (DA) concentration or the ratio DOPAC/DA. After reserpine administration the hypothalamic contents of NA and DA were drastically reduced without changing plasma corticosterone concentrations. The increase in plasma corticosterone induced by morphine was significantly reduced by the pretreatment with reserpine. The
α
1-andα
2-antagonists
prazosin and yohimbine, respectively, significantly antagonized the effect of morphine on plasma corticosterone. The β-antagonist propranolol also significantly attenuated the increase of corticosterone secretion induced by morphine. The results suggest that the action of the opiate on HPA axis activity may be dependent on stimulatory catecholaminergic systems which utilize
α
1-, α
2-andβ-adrenoceptors
. |
| doi_str_mv | 10.1016/0006-8993(94)90518-5 |
| format | Article |
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α
1-andα
2-antagonists
prazosin and yohimbine, respectively, significantly antagonized the effect of morphine on plasma corticosterone. The β-antagonist propranolol also significantly attenuated the increase of corticosterone secretion induced by morphine. The results suggest that the action of the opiate on HPA axis activity may be dependent on stimulatory catecholaminergic systems which utilize
α
1-, α
2-andβ-adrenoceptors
.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(94)90518-5</identifier><identifier>PMID: 7704598</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>3,4-Dihydroxyphenylacetic Acid - metabolism ; Adrenergic alpha-1 Receptor Agonists ; Adrenergic alpha-2 Receptor Agonists ; Adrenergic beta-Agonists - pharmacology ; Adrenergic blocking drug ; Adrenocorticotropic Hormone - metabolism ; Animals ; Biological and medical sciences ; Catecholamine ; Corticosterone - blood ; Corticotropin-Releasing Hormone - metabolism ; Dopamine - metabolism ; Fundamental and applied biological sciences. Psychology ; gamma-Aminobutyric Acid - metabolism ; Hormones and neuropeptides. Regulation ; HPA axis ; Hypothalamo-Hypophyseal System - drug effects ; Hypothalamo-Hypophyseal System - metabolism ; Hypothalamus ; Hypothalamus. Hypophysis. Epiphysis. Urophysis ; Male ; Morphine ; Morphine - pharmacology ; Norepinephrine - metabolism ; Pituitary-Adrenal System - drug effects ; Pituitary-Adrenal System - metabolism ; Prazosin - pharmacology ; Rats ; Rats, Sprague-Dawley ; Receptors, Adrenergic, alpha-1 - physiology ; Receptors, Adrenergic, alpha-2 - physiology ; Reserpine ; Vertebrates: endocrinology</subject><ispartof>Brain research, 1994-12, Vol.668 (1), p.122-128</ispartof><rights>1994 Elsevier Science B.V. All rights reserved</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c332t-69dac7fbbc48f53699e42d26edc3777599f41566467d61aa3551fe814c891b663</citedby><cites>FETCH-LOGICAL-c332t-69dac7fbbc48f53699e42d26edc3777599f41566467d61aa3551fe814c891b663</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0006899394905185$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3352288$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7704598$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Martinez-Pin˜ero, M. Gloria</creatorcontrib><creatorcontrib>Milanés, M. Victoria</creatorcontrib><creatorcontrib>Alcaraz, Cristina</creatorcontrib><creatorcontrib>Vargas, M. Luisa</creatorcontrib><title>Catecholaminergic mediation of morphine-induced activation of pituitary-adrenocortical axis in the rat: implication of α- and β-adrenoceptors</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>The present study investigates the role of hypothalamic catecholamines in the effects of morphine on hypothalamo-pituitary-adrenocortical (HPA) axis. Acutely administered morphine (30 mg/kg i.p) increased plasma corticosterone and reduced the hypothalamic noradrenaline (NA) content but it did not change either the dopamine (DA) concentration or the ratio DOPAC/DA. After reserpine administration the hypothalamic contents of NA and DA were drastically reduced without changing plasma corticosterone concentrations. The increase in plasma corticosterone induced by morphine was significantly reduced by the pretreatment with reserpine. The
α
1-andα
2-antagonists
prazosin and yohimbine, respectively, significantly antagonized the effect of morphine on plasma corticosterone. The β-antagonist propranolol also significantly attenuated the increase of corticosterone secretion induced by morphine. The results suggest that the action of the opiate on HPA axis activity may be dependent on stimulatory catecholaminergic systems which utilize
α
1-, α
2-andβ-adrenoceptors
.</description><subject>3,4-Dihydroxyphenylacetic Acid - metabolism</subject><subject>Adrenergic alpha-1 Receptor Agonists</subject><subject>Adrenergic alpha-2 Receptor Agonists</subject><subject>Adrenergic beta-Agonists - pharmacology</subject><subject>Adrenergic blocking drug</subject><subject>Adrenocorticotropic Hormone - metabolism</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Catecholamine</subject><subject>Corticosterone - blood</subject><subject>Corticotropin-Releasing Hormone - metabolism</subject><subject>Dopamine - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>gamma-Aminobutyric Acid - metabolism</subject><subject>Hormones and neuropeptides. Regulation</subject><subject>HPA axis</subject><subject>Hypothalamo-Hypophyseal System - drug effects</subject><subject>Hypothalamo-Hypophyseal System - metabolism</subject><subject>Hypothalamus</subject><subject>Hypothalamus. Hypophysis. Epiphysis. Urophysis</subject><subject>Male</subject><subject>Morphine</subject><subject>Morphine - pharmacology</subject><subject>Norepinephrine - metabolism</subject><subject>Pituitary-Adrenal System - drug effects</subject><subject>Pituitary-Adrenal System - metabolism</subject><subject>Prazosin - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, Adrenergic, alpha-1 - physiology</subject><subject>Receptors, Adrenergic, alpha-2 - physiology</subject><subject>Reserpine</subject><subject>Vertebrates: endocrinology</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2KFDEUhYMoY9v6BgpZiOgimlR-quJCkMY_GHCj65BOUvaVqkqZpAZ9Cp9FH2SeyZTd00tdhcv5ziGcg9BDRp8zytQLSqkindb8qRbPNJWsI_IW2rCubYhqBL2NNmfkLrqX89d6cq7pBbpoWyqk7jbo586W4A5xsCNMIX0Bh8fgwRaIE449HmOaD1UhMPnFBY-tK3B1lmcoCxSbfhDrU5iii6mAswO23yFjmHA5BJxseYlhnIeq3BivfxFsJ4-vf984w1xiyvfRnd4OOTw4vVv0-e2bT7v35PLjuw-715fEcd4UorS3ru33eye6XnKldRCNb1TwjrdtK7XuBZNKCdV6xazlUrI-dEy4TrO9UnyLnhxz5xS_LSEXM0J2YRjsFOKSTQ3phKT6vyBTSrO14i0SR9ClmHMKvZkTjLUaw6hZBzPrGmZFjRbm72BGVtujU_6yr82fTaeFqv74pNtci-2TnRzkM8a5bJpuxV4dsVBLu4KQTHYQproYpOCK8RH-_Y8_ktC1aA</recordid><startdate>19941230</startdate><enddate>19941230</enddate><creator>Martinez-Pin˜ero, M. Gloria</creator><creator>Milanés, M. Victoria</creator><creator>Alcaraz, Cristina</creator><creator>Vargas, M. Luisa</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19941230</creationdate><title>Catecholaminergic mediation of morphine-induced activation of pituitary-adrenocortical axis in the rat: implication of α- and β-adrenoceptors</title><author>Martinez-Pin˜ero, M. Gloria ; Milanés, M. Victoria ; Alcaraz, Cristina ; Vargas, M. Luisa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-69dac7fbbc48f53699e42d26edc3777599f41566467d61aa3551fe814c891b663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>3,4-Dihydroxyphenylacetic Acid - metabolism</topic><topic>Adrenergic alpha-1 Receptor Agonists</topic><topic>Adrenergic alpha-2 Receptor Agonists</topic><topic>Adrenergic beta-Agonists - pharmacology</topic><topic>Adrenergic blocking drug</topic><topic>Adrenocorticotropic Hormone - metabolism</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Catecholamine</topic><topic>Corticosterone - blood</topic><topic>Corticotropin-Releasing Hormone - metabolism</topic><topic>Dopamine - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>gamma-Aminobutyric Acid - metabolism</topic><topic>Hormones and neuropeptides. Regulation</topic><topic>HPA axis</topic><topic>Hypothalamo-Hypophyseal System - drug effects</topic><topic>Hypothalamo-Hypophyseal System - metabolism</topic><topic>Hypothalamus</topic><topic>Hypothalamus. Hypophysis. Epiphysis. Urophysis</topic><topic>Male</topic><topic>Morphine</topic><topic>Morphine - pharmacology</topic><topic>Norepinephrine - metabolism</topic><topic>Pituitary-Adrenal System - drug effects</topic><topic>Pituitary-Adrenal System - metabolism</topic><topic>Prazosin - pharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, Adrenergic, alpha-1 - physiology</topic><topic>Receptors, Adrenergic, alpha-2 - physiology</topic><topic>Reserpine</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Martinez-Pin˜ero, M. Gloria</creatorcontrib><creatorcontrib>Milanés, M. Victoria</creatorcontrib><creatorcontrib>Alcaraz, Cristina</creatorcontrib><creatorcontrib>Vargas, M. Luisa</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Martinez-Pin˜ero, M. Gloria</au><au>Milanés, M. Victoria</au><au>Alcaraz, Cristina</au><au>Vargas, M. Luisa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Catecholaminergic mediation of morphine-induced activation of pituitary-adrenocortical axis in the rat: implication of α- and β-adrenoceptors</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1994-12-30</date><risdate>1994</risdate><volume>668</volume><issue>1</issue><spage>122</spage><epage>128</epage><pages>122-128</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>The present study investigates the role of hypothalamic catecholamines in the effects of morphine on hypothalamo-pituitary-adrenocortical (HPA) axis. Acutely administered morphine (30 mg/kg i.p) increased plasma corticosterone and reduced the hypothalamic noradrenaline (NA) content but it did not change either the dopamine (DA) concentration or the ratio DOPAC/DA. After reserpine administration the hypothalamic contents of NA and DA were drastically reduced without changing plasma corticosterone concentrations. The increase in plasma corticosterone induced by morphine was significantly reduced by the pretreatment with reserpine. The
α
1-andα
2-antagonists
prazosin and yohimbine, respectively, significantly antagonized the effect of morphine on plasma corticosterone. The β-antagonist propranolol also significantly attenuated the increase of corticosterone secretion induced by morphine. The results suggest that the action of the opiate on HPA axis activity may be dependent on stimulatory catecholaminergic systems which utilize
α
1-, α
2-andβ-adrenoceptors
.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>7704598</pmid><doi>10.1016/0006-8993(94)90518-5</doi><tpages>7</tpages></addata></record> |
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| ispartof | Brain research, 1994-12, Vol.668 (1), p.122-128 |
| issn | 0006-8993 1872-6240 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77784509 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | 3,4-Dihydroxyphenylacetic Acid - metabolism Adrenergic alpha-1 Receptor Agonists Adrenergic alpha-2 Receptor Agonists Adrenergic beta-Agonists - pharmacology Adrenergic blocking drug Adrenocorticotropic Hormone - metabolism Animals Biological and medical sciences Catecholamine Corticosterone - blood Corticotropin-Releasing Hormone - metabolism Dopamine - metabolism Fundamental and applied biological sciences. Psychology gamma-Aminobutyric Acid - metabolism Hormones and neuropeptides. Regulation HPA axis Hypothalamo-Hypophyseal System - drug effects Hypothalamo-Hypophyseal System - metabolism Hypothalamus Hypothalamus. Hypophysis. Epiphysis. Urophysis Male Morphine Morphine - pharmacology Norepinephrine - metabolism Pituitary-Adrenal System - drug effects Pituitary-Adrenal System - metabolism Prazosin - pharmacology Rats Rats, Sprague-Dawley Receptors, Adrenergic, alpha-1 - physiology Receptors, Adrenergic, alpha-2 - physiology Reserpine Vertebrates: endocrinology |
| title | Catecholaminergic mediation of morphine-induced activation of pituitary-adrenocortical axis in the rat: implication of α- and β-adrenoceptors |
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