Discriminative power of visual evoked potential characteristics in multiple sclerosis

To investigate the discriminative power of pattern-reversal visual evoked potential characteristics (peak latencies and amplitude) and to test whether the addition of visual evoked potential amplitude can increase the power of the visual evoked potential in the diagnosis of multiple sclerosis, we re...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Documenta ophthalmologica 1995-01, Vol.90 (3), p.247-257
Hauptverfasser: CUYPERS, M. H. M, DICKSON, K, PINCKERS, A. J. L. G, THIJSSEN, J. M, HOMMES, O. R
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 257
container_issue 3
container_start_page 247
container_title Documenta ophthalmologica
container_volume 90
creator CUYPERS, M. H. M
DICKSON, K
PINCKERS, A. J. L. G
THIJSSEN, J. M
HOMMES, O. R
description To investigate the discriminative power of pattern-reversal visual evoked potential characteristics (peak latencies and amplitude) and to test whether the addition of visual evoked potential amplitude can increase the power of the visual evoked potential in the diagnosis of multiple sclerosis, we retrospectively studied visual evoked potentials in 59 patients with definite multiple sclerosis and 126 control subjects. Two check sizes (17' and 10') were used. Females had significantly higher amplitudes and shorter latencies than males. N80 latency showed a gradual increase and P100 amplitude a decrease with age. P100 latency was stable between the ages of 20 and 55 years but was increased in childhood and the elderly. The significance of visual evoked potential peak latencies and amplitude in separating the two groups was investigated by means of a (multivariate) discriminant analysis. The visual evoked potential with a pattern of 10' could be measured in 58% of patients with multiple sclerosis. The exclusive use of the P100 amplitude in the discriminant analysis resulted in a percentage of correctly classified cases of 84%, whereas for P100 and N80 latency it was 85% and 90%, respectively. With the 17' pattern, the N80 latency yielded also a higher correct percentage than did the P100 latency. Although N80 latency is, to a greater extent than P100 latency, influenced by age, sex and size of stimulus pattern, when these influences are accounted for, the N80 latency is a more sensitive measure than P100 latency in the classification of multiple sclerosis. Combined use of latency and amplitude for discriminant analysis yielded no significant improvement of the percentage of correctly classified cases.
doi_str_mv 10.1007/BF01203860
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_77784177</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>77784177</sourcerecordid><originalsourceid>FETCH-LOGICAL-c388t-ae79196bdde2e033de1dbd62e98ae0c57397d4d3d4160dbcbfe34c61f2f021c33</originalsourceid><addsrcrecordid>eNpFkM1LxDAUxIMo67p68S70IB6Eaj5qkh51dVVY8OKeS5q8YjT9MElX_O-NbNHTg5kfw5tB6JTgK4KxuL5bYUIxkxzvoTm5ESynnNJ9NMdJz4tC8kN0FMI7xrgURM7QTMqCC8bmaHNvg_a2tZ2KdgvZ0H-Bz_om29owKpfBtv8Ak-QIXbRJ0G_KKx3B2xCtDpntsnZ00Q4OsqAd-D7YcIwOGuUCnEx3gTarh9flU75-eXxe3q5zzaSMuQJRkpLXxgAFzJgBYmrDKZRSAdapSClMYZgpCMem1nUDrNCcNLTBlGjGFuhilzv4_nOEEKs21QHnVAf9GCohhCyIEAm83IE6_Rc8NNWQSiv_XRFc_W5Y_W-Y4LMpdaxbMH_oNFryzydfBa1c41WnbfjDGJcFpYT9AInSems</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>77784177</pqid></control><display><type>article</type><title>Discriminative power of visual evoked potential characteristics in multiple sclerosis</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>CUYPERS, M. H. M ; DICKSON, K ; PINCKERS, A. J. L. G ; THIJSSEN, J. M ; HOMMES, O. R</creator><creatorcontrib>CUYPERS, M. H. M ; DICKSON, K ; PINCKERS, A. J. L. G ; THIJSSEN, J. M ; HOMMES, O. R</creatorcontrib><description>To investigate the discriminative power of pattern-reversal visual evoked potential characteristics (peak latencies and amplitude) and to test whether the addition of visual evoked potential amplitude can increase the power of the visual evoked potential in the diagnosis of multiple sclerosis, we retrospectively studied visual evoked potentials in 59 patients with definite multiple sclerosis and 126 control subjects. Two check sizes (17' and 10') were used. Females had significantly higher amplitudes and shorter latencies than males. N80 latency showed a gradual increase and P100 amplitude a decrease with age. P100 latency was stable between the ages of 20 and 55 years but was increased in childhood and the elderly. The significance of visual evoked potential peak latencies and amplitude in separating the two groups was investigated by means of a (multivariate) discriminant analysis. The visual evoked potential with a pattern of 10' could be measured in 58% of patients with multiple sclerosis. The exclusive use of the P100 amplitude in the discriminant analysis resulted in a percentage of correctly classified cases of 84%, whereas for P100 and N80 latency it was 85% and 90%, respectively. With the 17' pattern, the N80 latency yielded also a higher correct percentage than did the P100 latency. Although N80 latency is, to a greater extent than P100 latency, influenced by age, sex and size of stimulus pattern, when these influences are accounted for, the N80 latency is a more sensitive measure than P100 latency in the classification of multiple sclerosis. Combined use of latency and amplitude for discriminant analysis yielded no significant improvement of the percentage of correctly classified cases.</description><identifier>ISSN: 0012-4486</identifier><identifier>EISSN: 1573-2622</identifier><identifier>DOI: 10.1007/BF01203860</identifier><identifier>PMID: 8846733</identifier><identifier>CODEN: DOOPAA</identifier><language>eng</language><publisher>Dordrecht: Springer</publisher><subject>Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Child ; Child, Preschool ; Evoked Potentials, Visual - physiology ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Multiple Sclerosis - diagnosis ; Multiple Sclerosis - physiopathology ; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis ; Neurology ; Reference Values ; Retrospective Studies ; Sex Factors</subject><ispartof>Documenta ophthalmologica, 1995-01, Vol.90 (3), p.247-257</ispartof><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-ae79196bdde2e033de1dbd62e98ae0c57397d4d3d4160dbcbfe34c61f2f021c33</citedby><cites>FETCH-LOGICAL-c388t-ae79196bdde2e033de1dbd62e98ae0c57397d4d3d4160dbcbfe34c61f2f021c33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=3684221$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8846733$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CUYPERS, M. H. M</creatorcontrib><creatorcontrib>DICKSON, K</creatorcontrib><creatorcontrib>PINCKERS, A. J. L. G</creatorcontrib><creatorcontrib>THIJSSEN, J. M</creatorcontrib><creatorcontrib>HOMMES, O. R</creatorcontrib><title>Discriminative power of visual evoked potential characteristics in multiple sclerosis</title><title>Documenta ophthalmologica</title><addtitle>Doc Ophthalmol</addtitle><description>To investigate the discriminative power of pattern-reversal visual evoked potential characteristics (peak latencies and amplitude) and to test whether the addition of visual evoked potential amplitude can increase the power of the visual evoked potential in the diagnosis of multiple sclerosis, we retrospectively studied visual evoked potentials in 59 patients with definite multiple sclerosis and 126 control subjects. Two check sizes (17' and 10') were used. Females had significantly higher amplitudes and shorter latencies than males. N80 latency showed a gradual increase and P100 amplitude a decrease with age. P100 latency was stable between the ages of 20 and 55 years but was increased in childhood and the elderly. The significance of visual evoked potential peak latencies and amplitude in separating the two groups was investigated by means of a (multivariate) discriminant analysis. The visual evoked potential with a pattern of 10' could be measured in 58% of patients with multiple sclerosis. The exclusive use of the P100 amplitude in the discriminant analysis resulted in a percentage of correctly classified cases of 84%, whereas for P100 and N80 latency it was 85% and 90%, respectively. With the 17' pattern, the N80 latency yielded also a higher correct percentage than did the P100 latency. Although N80 latency is, to a greater extent than P100 latency, influenced by age, sex and size of stimulus pattern, when these influences are accounted for, the N80 latency is a more sensitive measure than P100 latency in the classification of multiple sclerosis. Combined use of latency and amplitude for discriminant analysis yielded no significant improvement of the percentage of correctly classified cases.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Evoked Potentials, Visual - physiology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multiple Sclerosis - diagnosis</subject><subject>Multiple Sclerosis - physiopathology</subject><subject>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</subject><subject>Neurology</subject><subject>Reference Values</subject><subject>Retrospective Studies</subject><subject>Sex Factors</subject><issn>0012-4486</issn><issn>1573-2622</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM1LxDAUxIMo67p68S70IB6Eaj5qkh51dVVY8OKeS5q8YjT9MElX_O-NbNHTg5kfw5tB6JTgK4KxuL5bYUIxkxzvoTm5ESynnNJ9NMdJz4tC8kN0FMI7xrgURM7QTMqCC8bmaHNvg_a2tZ2KdgvZ0H-Bz_om29owKpfBtv8Ak-QIXbRJ0G_KKx3B2xCtDpntsnZ00Q4OsqAd-D7YcIwOGuUCnEx3gTarh9flU75-eXxe3q5zzaSMuQJRkpLXxgAFzJgBYmrDKZRSAdapSClMYZgpCMem1nUDrNCcNLTBlGjGFuhilzv4_nOEEKs21QHnVAf9GCohhCyIEAm83IE6_Rc8NNWQSiv_XRFc_W5Y_W-Y4LMpdaxbMH_oNFryzydfBa1c41WnbfjDGJcFpYT9AInSems</recordid><startdate>19950101</startdate><enddate>19950101</enddate><creator>CUYPERS, M. H. M</creator><creator>DICKSON, K</creator><creator>PINCKERS, A. J. L. G</creator><creator>THIJSSEN, J. M</creator><creator>HOMMES, O. R</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19950101</creationdate><title>Discriminative power of visual evoked potential characteristics in multiple sclerosis</title><author>CUYPERS, M. H. M ; DICKSON, K ; PINCKERS, A. J. L. G ; THIJSSEN, J. M ; HOMMES, O. R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-ae79196bdde2e033de1dbd62e98ae0c57397d4d3d4160dbcbfe34c61f2f021c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Evoked Potentials, Visual - physiology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multiple Sclerosis - diagnosis</topic><topic>Multiple Sclerosis - physiopathology</topic><topic>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</topic><topic>Neurology</topic><topic>Reference Values</topic><topic>Retrospective Studies</topic><topic>Sex Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CUYPERS, M. H. M</creatorcontrib><creatorcontrib>DICKSON, K</creatorcontrib><creatorcontrib>PINCKERS, A. J. L. G</creatorcontrib><creatorcontrib>THIJSSEN, J. M</creatorcontrib><creatorcontrib>HOMMES, O. R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Documenta ophthalmologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CUYPERS, M. H. M</au><au>DICKSON, K</au><au>PINCKERS, A. J. L. G</au><au>THIJSSEN, J. M</au><au>HOMMES, O. R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Discriminative power of visual evoked potential characteristics in multiple sclerosis</atitle><jtitle>Documenta ophthalmologica</jtitle><addtitle>Doc Ophthalmol</addtitle><date>1995-01-01</date><risdate>1995</risdate><volume>90</volume><issue>3</issue><spage>247</spage><epage>257</epage><pages>247-257</pages><issn>0012-4486</issn><eissn>1573-2622</eissn><coden>DOOPAA</coden><abstract>To investigate the discriminative power of pattern-reversal visual evoked potential characteristics (peak latencies and amplitude) and to test whether the addition of visual evoked potential amplitude can increase the power of the visual evoked potential in the diagnosis of multiple sclerosis, we retrospectively studied visual evoked potentials in 59 patients with definite multiple sclerosis and 126 control subjects. Two check sizes (17' and 10') were used. Females had significantly higher amplitudes and shorter latencies than males. N80 latency showed a gradual increase and P100 amplitude a decrease with age. P100 latency was stable between the ages of 20 and 55 years but was increased in childhood and the elderly. The significance of visual evoked potential peak latencies and amplitude in separating the two groups was investigated by means of a (multivariate) discriminant analysis. The visual evoked potential with a pattern of 10' could be measured in 58% of patients with multiple sclerosis. The exclusive use of the P100 amplitude in the discriminant analysis resulted in a percentage of correctly classified cases of 84%, whereas for P100 and N80 latency it was 85% and 90%, respectively. With the 17' pattern, the N80 latency yielded also a higher correct percentage than did the P100 latency. Although N80 latency is, to a greater extent than P100 latency, influenced by age, sex and size of stimulus pattern, when these influences are accounted for, the N80 latency is a more sensitive measure than P100 latency in the classification of multiple sclerosis. Combined use of latency and amplitude for discriminant analysis yielded no significant improvement of the percentage of correctly classified cases.</abstract><cop>Dordrecht</cop><pub>Springer</pub><pmid>8846733</pmid><doi>10.1007/BF01203860</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0012-4486
ispartof Documenta ophthalmologica, 1995-01, Vol.90 (3), p.247-257
issn 0012-4486
1573-2622
language eng
recordid cdi_proquest_miscellaneous_77784177
source MEDLINE; SpringerNature Journals
subjects Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Biological and medical sciences
Child
Child, Preschool
Evoked Potentials, Visual - physiology
Female
Humans
Male
Medical sciences
Middle Aged
Multiple Sclerosis - diagnosis
Multiple Sclerosis - physiopathology
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Neurology
Reference Values
Retrospective Studies
Sex Factors
title Discriminative power of visual evoked potential characteristics in multiple sclerosis
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T06%3A06%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Discriminative%20power%20of%20visual%20evoked%20potential%20characteristics%20in%20multiple%20sclerosis&rft.jtitle=Documenta%20ophthalmologica&rft.au=CUYPERS,%20M.%20H.%20M&rft.date=1995-01-01&rft.volume=90&rft.issue=3&rft.spage=247&rft.epage=257&rft.pages=247-257&rft.issn=0012-4486&rft.eissn=1573-2622&rft.coden=DOOPAA&rft_id=info:doi/10.1007/BF01203860&rft_dat=%3Cproquest_cross%3E77784177%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=77784177&rft_id=info:pmid/8846733&rfr_iscdi=true