An Acute Phase Response Factor/NF-κB Site Downstream of the junB Gene That Mediates Responsiveness to Interleukin-6 in a Murine Plasmacytoma (∗)

The immediate early gene, junB, is induced by interleukin-6 (IL-6) in plasmacytomas. In order to identify enhancers that mediate this effect, we cloned upstream and downstream sequences flanking the gene into a luciferase reporter gene vector containing the junB promoter and evaluated the IL-6 induc...

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Veröffentlicht in:	The Journal of biological chemistry 1995-12, Vol.270 (52), p.31129-31135
Hauptverfasser:	Brown, Robert T., Ades, Ibrahim Z., Nordan, Richard P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Binding Sites DNA-Binding Proteins - metabolism Enhancer Elements, Genetic Gene Expression Regulation, Neoplastic - physiology Genes, jun Interleukin-6 - physiology Mice Mice, Inbred BALB C Molecular Sequence Data NF-kappa B - metabolism Nuclear Proteins - metabolism Oligodeoxyribonucleotides Plasmacytoma - genetics Plasmacytoma - metabolism Promoter Regions, Genetic STAT3 Transcription Factor Trans-Activators
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