The use of multiple doses and pharmacodynamic system analysis to distinguish between dispositional delays and time-variant pharmacodynamics

Pharmacokinetic-pharmacodynamic modeling algorithms, in general, rely on hysteresis minimization techniques that assume time-invariant pharmacodynamics (constant biophase concentration-effect relationships). When time-variant pharmacodynamics are observed, a specific model for tolerance or sensitiza...

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Veröffentlicht in:	Pharmaceutical research 1994-12, Vol.11 (12), p.1825-1828
Hauptverfasser:	GASTONGUAY, M. R, SCHWARTZ, S. L
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Dose-Response Relationship, Drug Drug Tolerance General pharmacology Humans Medical sciences Models, Biological Pharmacokinetics Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments
Online-Zugang:	Volltext
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