Structure-function relationships of des-(B26-B30)-insulin

In order to study the role of the amino acid in position B25 and its environment in shortened insulins, a series of analogues was prepared with the following modifications; 1, Stepwise shortening of the B‐chain including replacements of TyrB26 and ThrB27 by glycine; 2, substitutions at the carboxami...

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Veröffentlicht in:	International Journal of Peptide and Protein Research 1995-09, Vol.46 (3-4), p.221-227
Hauptverfasser:	SPODEN, MARTIN, GATTNER, HANS-GREGOR, ZAHN, HELMUT, BRANDENBURG, DIETRICH
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes - drug effects Adipocytes - metabolism Amino Acid Sequence Animals biological activity Cell Line Chromatography, Gel Circular Dichroism Electrochemistry enzyme-catalyzed semisynthesis Humans Hydrogen-Ion Concentration Insulin - analogs & derivatives Insulin - chemistry Insulin - metabolism Insulin - pharmacology insulin analogues Lipids - biosynthesis Lymphocytes - metabolism Molecular Sequence Data Peptide Fragments - chemistry Peptide Fragments - metabolism Rats receptor binding Receptor, Insulin - metabolism Structure-Activity Relationship superpotency Trypsin - metabolism
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