[ O-methyl- 11C]β-CIT-FP, a potential radioligand for quantitation of the dopamine transporter: Preparation, autoradiography, metabolite studies, and positron emission tomography examinations

β-CIT-FP [ N-(3-fluoropropyl)-2β-carbomethoxy-3β-(4-iodophenyl)nortropane] is a cocaine analogue with a high affinity for the dopamine transporter. [ O-methyl- 11C]β-CIT-FP ([ 11C]β-CIT-FP) was prepared by O-alkylation of the free acid with [ 11C]methyl iodide. The total radiochemical yield of [ 11C...

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Veröffentlicht in:	International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology Nuclear medicine and biology, 1995-10, Vol.22 (7), p.905-913
Hauptverfasser:	Lundkvist, Camilla, Halldin, Christer, Swahn, Carl-Gunnar, Hall, Håkan, Karlsson, Per, Nakashima, Yoshifumi, Wang, Shaoyin, Milius, Richard A., Neumeyer, John L., Farde, Lars
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoradiography Biological and medical sciences Brain - diagnostic imaging Brain - metabolism Carbon Radioisotopes Carrier Proteins - metabolism Chromatography, High Pressure Liquid Contrast media. Radiopharmaceuticals Dopamine Plasma Membrane Transport Proteins Humans Hydrocarbons, Iodinated - chemistry Macaca fascicularis Medical sciences Membrane Glycoproteins Membrane Transport Proteins Nerve Tissue Proteins Pharmacology. Drug treatments Radioligand Assay Tomography, Emission-Computed - methods Tropanes - blood Tropanes - chemistry Tropanes - metabolism
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