Local Release of Fibrinolytic Agents for Adhesion Prevention

Tissue plasminogen activator (tPA), urokinase plasminogen activator (uPA), and streptokinase were evaluated for their ability to reduce postsurgical adhesion formation in a rat uterine horn devascularization and serosal injury model in a blinded, randomized study. Small doses of tPA, uPA, or strepto...

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Veröffentlicht in:	The Journal of surgical research 1995-12, Vol.59 (6), p.759-763
Hauptverfasser:	Hill-West, Jennifer L., Dunn, Randall C., Hubbell, Jeffrey A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Digestive system Drug Implants Female Hydrogel, Polyethylene Glycol Dimethacrylate Injections, Intraperitoneal Medical sciences Pharmacology. Drug treatments Polyethylene Glycols Postoperative Complications - prevention & control Rats Rats, Sprague-Dawley Streptokinase - administration & dosage Streptokinase - pharmacology Tissue Adhesions - prevention & control Tissue Plasminogen Activator - administration & dosage Tissue Plasminogen Activator - pharmacology Urokinase-Type Plasminogen Activator - administration & dosage Urokinase-Type Plasminogen Activator - pharmacology Uterine Diseases - prevention & control Uterus - surgery
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