Genetic Mapping of a Gene Encoding an Atypical Protein Kinase C, Protein Kinase C Lambda, to the Proximal Region of Mouse Chromosome 3
Protein kinase C are a class of proteins that mediate the control of cellular responses to external stimuli through the phosphorylation of target proteins . We have recently described the isolation of a human gene encoding a new member of the atypical class of protein kinase C, protein kinase C sub(...
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| Veröffentlicht in: | Genomics 1995-10, Vol.29 (3), p.815-816 |
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| creator | Quaderi, Nandita A. Gianfrancesco, Fernando Brown, Steve D.M. D'Urso, Michele D'Esposito, Maurizio |
| description | Protein kinase C are a class of proteins that mediate the control of cellular responses to external stimuli through the phosphorylation of target proteins . We have recently described the isolation of a human gene encoding a new member of the atypical class of protein kinase C, protein kinase C sub( iota ) (PKC sub( iota )), which we showed mapped to Xq21.3, close to the BTK gene. The atypical class of protein kinase C contains at least three members, protein kinase C lambda , protein kinase C zeta , and the previously mentioned protein kinase C iota , although further members have been predicted to exist on the basis of genomic Southern blotting. To clone the mouse genes for new members of the atypical class of protein kinase C, we screened a mouse 11.5-day embryonic cDNA library with a 2.2-kb cDNA representing the entire human PKC sub( iota ) gene. A FASTA search of the GenBank database using 1.5 kb of consensus cDNA sequence, containing mainly 3' untranslated sequence, revealed 99% identity at the nucleotide level with mouse protein kinase C lambda (Accession No. D28577). Protein kinase C lambda (PKC lambda ) has been previously characterized by Akimoto et al., but the gene encoding it had not been mapped in mouse or human. |
| doi_str_mv | 10.1006/geno.1995.9923 |
| format | Article |
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We have recently described the isolation of a human gene encoding a new member of the atypical class of protein kinase C, protein kinase C sub( iota ) (PKC sub( iota )), which we showed mapped to Xq21.3, close to the BTK gene. The atypical class of protein kinase C contains at least three members, protein kinase C lambda , protein kinase C zeta , and the previously mentioned protein kinase C iota , although further members have been predicted to exist on the basis of genomic Southern blotting. To clone the mouse genes for new members of the atypical class of protein kinase C, we screened a mouse 11.5-day embryonic cDNA library with a 2.2-kb cDNA representing the entire human PKC sub( iota ) gene. A FASTA search of the GenBank database using 1.5 kb of consensus cDNA sequence, containing mainly 3' untranslated sequence, revealed 99% identity at the nucleotide level with mouse protein kinase C lambda (Accession No. D28577). Protein kinase C lambda (PKC lambda ) has been previously characterized by Akimoto et al., but the gene encoding it had not been mapped in mouse or human.</description><identifier>ISSN: 0888-7543</identifier><identifier>EISSN: 1089-8646</identifier><identifier>DOI: 10.1006/geno.1995.9923</identifier><identifier>PMID: 8575788</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; BIOLOGICAL MARKERS ; BIOLOGY AND MEDICINE, BASIC STUDIES ; CELL DIFFERENTIATION ; Chromosome Mapping ; CHROMOSOMES ; Classical genetics, quantitative genetics, hybrids ; Crosses, Genetic ; DNA SEQUENCING ; DNA, Complementary ; DNA-CLONING ; Embryo, Mammalian ; Fundamental and applied biological sciences. Psychology ; Gene Library ; GENE REGULATION ; GENETIC MAPPING ; Genetic Markers ; Genetics of eukaryotes. Biological and molecular evolution ; HUMAN X CHROMOSOME ; Humans ; Isoenzymes - biosynthesis ; Isoenzymes - genetics ; MICE ; Mice, Inbred C57BL ; Molecular Sequence Data ; Muridae ; PHOSPHORYLATION ; PHOSPHOTRANSFERASES ; Protein Kinase C - biosynthesis ; Protein Kinase C - genetics ; PROTEINS ; Restriction Mapping ; TISSUE DISTRIBUTION ; TRANSCRIPTION ; Transcription, Genetic ; TUMOR CELLS ; Vertebrata</subject><ispartof>Genomics, 1995-10, Vol.29 (3), p.815-816</ispartof><rights>1995</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0888754385799235$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,881,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2890402$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8575788$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/443894$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Quaderi, Nandita A.</creatorcontrib><creatorcontrib>Gianfrancesco, Fernando</creatorcontrib><creatorcontrib>Brown, Steve D.M.</creatorcontrib><creatorcontrib>D'Urso, Michele</creatorcontrib><creatorcontrib>D'Esposito, Maurizio</creatorcontrib><title>Genetic Mapping of a Gene Encoding an Atypical Protein Kinase C, Protein Kinase C Lambda, to the Proximal Region of Mouse Chromosome 3</title><title>Genomics</title><addtitle>Genomics</addtitle><description>Protein kinase C are a class of proteins that mediate the control of cellular responses to external stimuli through the phosphorylation of target proteins . We have recently described the isolation of a human gene encoding a new member of the atypical class of protein kinase C, protein kinase C sub( iota ) (PKC sub( iota )), which we showed mapped to Xq21.3, close to the BTK gene. The atypical class of protein kinase C contains at least three members, protein kinase C lambda , protein kinase C zeta , and the previously mentioned protein kinase C iota , although further members have been predicted to exist on the basis of genomic Southern blotting. To clone the mouse genes for new members of the atypical class of protein kinase C, we screened a mouse 11.5-day embryonic cDNA library with a 2.2-kb cDNA representing the entire human PKC sub( iota ) gene. A FASTA search of the GenBank database using 1.5 kb of consensus cDNA sequence, containing mainly 3' untranslated sequence, revealed 99% identity at the nucleotide level with mouse protein kinase C lambda (Accession No. D28577). Protein kinase C lambda (PKC lambda ) has been previously characterized by Akimoto et al., but the gene encoding it had not been mapped in mouse or human.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>BIOLOGICAL MARKERS</subject><subject>BIOLOGY AND MEDICINE, BASIC STUDIES</subject><subject>CELL DIFFERENTIATION</subject><subject>Chromosome Mapping</subject><subject>CHROMOSOMES</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>Crosses, Genetic</subject><subject>DNA SEQUENCING</subject><subject>DNA, Complementary</subject><subject>DNA-CLONING</subject><subject>Embryo, Mammalian</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Library</subject><subject>GENE REGULATION</subject><subject>GENETIC MAPPING</subject><subject>Genetic Markers</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>HUMAN X CHROMOSOME</subject><subject>Humans</subject><subject>Isoenzymes - biosynthesis</subject><subject>Isoenzymes - genetics</subject><subject>MICE</subject><subject>Mice, Inbred C57BL</subject><subject>Molecular Sequence Data</subject><subject>Muridae</subject><subject>PHOSPHORYLATION</subject><subject>PHOSPHOTRANSFERASES</subject><subject>Protein Kinase C - biosynthesis</subject><subject>Protein Kinase C - genetics</subject><subject>PROTEINS</subject><subject>Restriction Mapping</subject><subject>TISSUE DISTRIBUTION</subject><subject>TRANSCRIPTION</subject><subject>Transcription, Genetic</subject><subject>TUMOR CELLS</subject><subject>Vertebrata</subject><issn>0888-7543</issn><issn>1089-8646</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1rFDEYx4Moda1evQkRiqfOmkkmb8ey1La4RRE9D5nMs7uRnWRMsmK_gJ_bhF16ETGXwPP_Pa9_hF63ZNkSIt5vwYdlqzVfak3ZE7RoidKNEp14ihZEKdVI3rHn6EVK3wkhmil6hs4Ul1wqtUC_b8BDdhbfm3l2fovDBhtcg_ja2zDWkPH4Kj_Mzpo9_hxDBufxR-dNAry6_CuC12YaRnOJc8B5B1X_5aaS-gW2Lvja4D4cKrmLYQopTIDZS_RsY_YJXp3-c_Ttw_XX1W2z_nRzt7paN5ZqnhuuiLFaDwSoFnJUgzGESsGIUJxwzcXIy2JKaiO6YSg5AEZSK6joulYxxs7R22PdkLLrk3UZ7M4G78HmvuuY0l1h3h2ZOYYfB0i5n1yysN8bD2XwXpYnOJP_BVtJCBUtLeDyCNoYUoqw6edYThIf-pb01cW-uthXF_vqYkl4c6p8GCYYH_GTbUW_OOkmFVc20Xjr0iNGlSYdqX3VEYNy0p8OYt0YvIXRxbrwGNy_JvgDNw21zA</recordid><startdate>19951010</startdate><enddate>19951010</enddate><creator>Quaderi, Nandita A.</creator><creator>Gianfrancesco, Fernando</creator><creator>Brown, Steve D.M.</creator><creator>D'Urso, Michele</creator><creator>D'Esposito, Maurizio</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>19951010</creationdate><title>Genetic Mapping of a Gene Encoding an Atypical Protein Kinase C, Protein Kinase C Lambda, to the Proximal Region of Mouse Chromosome 3</title><author>Quaderi, Nandita A. ; Gianfrancesco, Fernando ; Brown, Steve D.M. ; D'Urso, Michele ; D'Esposito, Maurizio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c295t-580ac99b0e2967d8baa02763068505956d5575879a64bbc29eea72c6264418333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>BIOLOGICAL MARKERS</topic><topic>BIOLOGY AND MEDICINE, BASIC STUDIES</topic><topic>CELL DIFFERENTIATION</topic><topic>Chromosome Mapping</topic><topic>CHROMOSOMES</topic><topic>Classical genetics, quantitative genetics, hybrids</topic><topic>Crosses, Genetic</topic><topic>DNA SEQUENCING</topic><topic>DNA, Complementary</topic><topic>DNA-CLONING</topic><topic>Embryo, Mammalian</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Library</topic><topic>GENE REGULATION</topic><topic>GENETIC MAPPING</topic><topic>Genetic Markers</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>HUMAN X CHROMOSOME</topic><topic>Humans</topic><topic>Isoenzymes - biosynthesis</topic><topic>Isoenzymes - genetics</topic><topic>MICE</topic><topic>Mice, Inbred C57BL</topic><topic>Molecular Sequence Data</topic><topic>Muridae</topic><topic>PHOSPHORYLATION</topic><topic>PHOSPHOTRANSFERASES</topic><topic>Protein Kinase C - biosynthesis</topic><topic>Protein Kinase C - genetics</topic><topic>PROTEINS</topic><topic>Restriction Mapping</topic><topic>TISSUE DISTRIBUTION</topic><topic>TRANSCRIPTION</topic><topic>Transcription, Genetic</topic><topic>TUMOR CELLS</topic><topic>Vertebrata</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Quaderi, Nandita A.</creatorcontrib><creatorcontrib>Gianfrancesco, Fernando</creatorcontrib><creatorcontrib>Brown, Steve D.M.</creatorcontrib><creatorcontrib>D'Urso, Michele</creatorcontrib><creatorcontrib>D'Esposito, Maurizio</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Genomics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Quaderi, Nandita A.</au><au>Gianfrancesco, Fernando</au><au>Brown, Steve D.M.</au><au>D'Urso, Michele</au><au>D'Esposito, Maurizio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic Mapping of a Gene Encoding an Atypical Protein Kinase C, Protein Kinase C Lambda, to the Proximal Region of Mouse Chromosome 3</atitle><jtitle>Genomics</jtitle><addtitle>Genomics</addtitle><date>1995-10-10</date><risdate>1995</risdate><volume>29</volume><issue>3</issue><spage>815</spage><epage>816</epage><pages>815-816</pages><issn>0888-7543</issn><eissn>1089-8646</eissn><abstract>Protein kinase C are a class of proteins that mediate the control of cellular responses to external stimuli through the phosphorylation of target proteins . We have recently described the isolation of a human gene encoding a new member of the atypical class of protein kinase C, protein kinase C sub( iota ) (PKC sub( iota )), which we showed mapped to Xq21.3, close to the BTK gene. The atypical class of protein kinase C contains at least three members, protein kinase C lambda , protein kinase C zeta , and the previously mentioned protein kinase C iota , although further members have been predicted to exist on the basis of genomic Southern blotting. To clone the mouse genes for new members of the atypical class of protein kinase C, we screened a mouse 11.5-day embryonic cDNA library with a 2.2-kb cDNA representing the entire human PKC sub( iota ) gene. A FASTA search of the GenBank database using 1.5 kb of consensus cDNA sequence, containing mainly 3' untranslated sequence, revealed 99% identity at the nucleotide level with mouse protein kinase C lambda (Accession No. D28577). Protein kinase C lambda (PKC lambda ) has been previously characterized by Akimoto et al., but the gene encoding it had not been mapped in mouse or human.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>8575788</pmid><doi>10.1006/geno.1995.9923</doi><tpages>2</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences BIOLOGICAL MARKERS BIOLOGY AND MEDICINE, BASIC STUDIES CELL DIFFERENTIATION Chromosome Mapping CHROMOSOMES Classical genetics, quantitative genetics, hybrids Crosses, Genetic DNA SEQUENCING DNA, Complementary DNA-CLONING Embryo, Mammalian Fundamental and applied biological sciences. Psychology Gene Library GENE REGULATION GENETIC MAPPING Genetic Markers Genetics of eukaryotes. Biological and molecular evolution HUMAN X CHROMOSOME Humans Isoenzymes - biosynthesis Isoenzymes - genetics MICE Mice, Inbred C57BL Molecular Sequence Data Muridae PHOSPHORYLATION PHOSPHOTRANSFERASES Protein Kinase C - biosynthesis Protein Kinase C - genetics PROTEINS Restriction Mapping TISSUE DISTRIBUTION TRANSCRIPTION Transcription, Genetic TUMOR CELLS Vertebrata |
| title | Genetic Mapping of a Gene Encoding an Atypical Protein Kinase C, Protein Kinase C Lambda, to the Proximal Region of Mouse Chromosome 3 |
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