Lovastatin inhibits receptor-stimulated Ca(2+)-influx in retinoic acid differentiated U937 and HL-60 cells

Lovastatin was used to study the role of isoprenylated proteins on stimulus-induced increase of cytosolic Ca2+ in retinoic acid-differentiated U937 and HL-60 cells. Preincubation of the cells with lovastatin for 11-24 h reduced the Ca(2+)-influx induced by PAF of FMLP. The maximal decrease was 60% i...

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Veröffentlicht in:	Cellular signalling 1994-09, Vol.6 (7), p.735-742
Hauptverfasser:	Haag, H, Grünberg, B, Weber, C, Vauti, F, Aepfelbacher, M, Siess, W
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcium - metabolism Cell Differentiation - drug effects Cell Division - drug effects Cell Line Cell Survival - drug effects Cytosol - metabolism Humans Ion Transport - drug effects Lovastatin - pharmacology ras Proteins - metabolism Tretinoin - pharmacology
Online-Zugang:	Volltext
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