Tissue Plasminogen Activator Induction in Purkinje Neurons After Cerebellar Motor Learning
The cerebellar cortex is implicated in the learning of complex motor skills. This learning may require synaptic remodeling of Purkinje cell inputs. An extracellular serine protease, tissue plasminogen activator (tPA), is involved in remodeling various nonneural tissues and is associated with develop...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1995-12, Vol.270 (5244), p.1992-1994 |
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| container_end_page | 1994 |
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| container_issue | 5244 |
| container_start_page | 1992 |
| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 270 |
| creator | Seeds, Nicholas W. Williams, Brian L. Bickford, Paula C. |
| description | The cerebellar cortex is implicated in the learning of complex motor skills. This learning may require synaptic remodeling of Purkinje cell inputs. An extracellular serine protease, tissue plasminogen activator (tPA), is involved in remodeling various nonneural tissues and is associated with developing and regenerating neurons. In situ hybridization showed that expression of tPA messenger RNA was increased in the Purkinje neurons of rats within an hour of their being trained for a complex motor task. Antibody to tPA also showed the induction of tPA protein associated with cerebellar Purkinje cells. Thus, the induction of tPA during motor learning may play a role in activity-dependent synaptic plasticity. |
| doi_str_mv | 10.1126/science.270.5244.1992 |
| format | Article |
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This learning may require synaptic remodeling of Purkinje cell inputs. An extracellular serine protease, tissue plasminogen activator (tPA), is involved in remodeling various nonneural tissues and is associated with developing and regenerating neurons. In situ hybridization showed that expression of tPA messenger RNA was increased in the Purkinje neurons of rats within an hour of their being trained for a complex motor task. Antibody to tPA also showed the induction of tPA protein associated with cerebellar Purkinje cells. Thus, the induction of tPA during motor learning may play a role in activity-dependent synaptic plasticity.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.270.5244.1992</identifier><identifier>PMID: 8533091</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Society for the Advancement of Science</publisher><subject>Anatomical correlates of behavior ; Animals ; Behavioral psychophysiology ; Biological and medical sciences ; Brain ; Cerebellum ; Cerebellum - enzymology ; Complementary RNA ; Enzyme Induction ; Fundamental and applied biological sciences. Psychology ; In Situ Hybridization ; Learning - physiology ; Logical Thinking ; Long Term Memory ; Male ; Mathematical induction ; Mathematical Models ; Messenger RNA ; Motor learning ; Motor Skills - physiology ; Neurology ; Neuronal Plasticity ; Neurons ; Physical Conditioning, Animal ; Physiological aspects ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Psychomotor Performance - physiology ; Psychomotor Skills ; Purkinje cells ; Purkinje Cells - enzymology ; Rats ; Rats, Inbred F344 ; Renovations ; Ribonucleic acid ; RNA ; Skill Development ; Tissue plasminogen activator ; Tissue Plasminogen Activator - biosynthesis ; Tissue Plasminogen Activator - genetics ; Training</subject><ispartof>Science (American Association for the Advancement of Science), 1995-12, Vol.270 (5244), p.1992-1994</ispartof><rights>Copyright 1995 American Association for the Advancement of Science</rights><rights>1996 INIST-CNRS</rights><rights>COPYRIGHT 1995 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1995 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Dec 22, 1995</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c815t-ff72ab2f81611fb174a56d4f4b15c729f2230201bcdd2fc12ecb9f6d7e09d05e3</citedby><cites>FETCH-LOGICAL-c815t-ff72ab2f81611fb174a56d4f4b15c729f2230201bcdd2fc12ecb9f6d7e09d05e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2888830$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2888830$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2944448$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8533091$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Seeds, Nicholas W.</creatorcontrib><creatorcontrib>Williams, Brian L.</creatorcontrib><creatorcontrib>Bickford, Paula C.</creatorcontrib><title>Tissue Plasminogen Activator Induction in Purkinje Neurons After Cerebellar Motor Learning</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>The cerebellar cortex is implicated in the learning of complex motor skills. This learning may require synaptic remodeling of Purkinje cell inputs. An extracellular serine protease, tissue plasminogen activator (tPA), is involved in remodeling various nonneural tissues and is associated with developing and regenerating neurons. In situ hybridization showed that expression of tPA messenger RNA was increased in the Purkinje neurons of rats within an hour of their being trained for a complex motor task. Antibody to tPA also showed the induction of tPA protein associated with cerebellar Purkinje cells. Thus, the induction of tPA during motor learning may play a role in activity-dependent synaptic plasticity.</description><subject>Anatomical correlates of behavior</subject><subject>Animals</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Cerebellum</subject><subject>Cerebellum - enzymology</subject><subject>Complementary RNA</subject><subject>Enzyme Induction</subject><subject>Fundamental and applied biological sciences. 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Psychology</topic><topic>In Situ Hybridization</topic><topic>Learning - physiology</topic><topic>Logical Thinking</topic><topic>Long Term Memory</topic><topic>Male</topic><topic>Mathematical induction</topic><topic>Mathematical Models</topic><topic>Messenger RNA</topic><topic>Motor learning</topic><topic>Motor Skills - physiology</topic><topic>Neurology</topic><topic>Neuronal Plasticity</topic><topic>Neurons</topic><topic>Physical Conditioning, Animal</topic><topic>Physiological aspects</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. 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This learning may require synaptic remodeling of Purkinje cell inputs. An extracellular serine protease, tissue plasminogen activator (tPA), is involved in remodeling various nonneural tissues and is associated with developing and regenerating neurons. In situ hybridization showed that expression of tPA messenger RNA was increased in the Purkinje neurons of rats within an hour of their being trained for a complex motor task. Antibody to tPA also showed the induction of tPA protein associated with cerebellar Purkinje cells. Thus, the induction of tPA during motor learning may play a role in activity-dependent synaptic plasticity.</abstract><cop>Washington, DC</cop><pub>American Society for the Advancement of Science</pub><pmid>8533091</pmid><doi>10.1126/science.270.5244.1992</doi><tpages>3</tpages></addata></record> |
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| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1995-12, Vol.270 (5244), p.1992-1994 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77775277 |
| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | Anatomical correlates of behavior Animals Behavioral psychophysiology Biological and medical sciences Brain Cerebellum Cerebellum - enzymology Complementary RNA Enzyme Induction Fundamental and applied biological sciences. Psychology In Situ Hybridization Learning - physiology Logical Thinking Long Term Memory Male Mathematical induction Mathematical Models Messenger RNA Motor learning Motor Skills - physiology Neurology Neuronal Plasticity Neurons Physical Conditioning, Animal Physiological aspects Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychomotor Performance - physiology Psychomotor Skills Purkinje cells Purkinje Cells - enzymology Rats Rats, Inbred F344 Renovations Ribonucleic acid RNA Skill Development Tissue plasminogen activator Tissue Plasminogen Activator - biosynthesis Tissue Plasminogen Activator - genetics Training |
| title | Tissue Plasminogen Activator Induction in Purkinje Neurons After Cerebellar Motor Learning |
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