Age-related changes in learning, memory, and lipofuscin as a function of the percentage of SAMP8 genes

SAMP8 (P8) mice are characterized by impaired learning and memory relatively early in their life, while CD-1 mice show impairment later in life. A series of paternal backcross strains were developed from a CD-1 dame and P8 sire. Siblings from each backcross were bred to establish strains with 50% to...

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Veröffentlicht in:	Physiology & behavior 1995-10, Vol.58 (4), p.819-822
Hauptverfasser:	Flood, James F., Morley, Patricia M.K., Morley, John E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging - genetics Animals Avoidance Learning - physiology Behavioral psychophysiology Biological and medical sciences Crosses, Genetic Female Fundamental and applied biological sciences. Psychology Genes Genes, Recessive - genetics Genotype Hippocampus Hippocampus - anatomy & histology Inheritance Learning Lipofuscin Lipofuscin - genetics Male Maze Learning - physiology Memory Mental Recall - physiology Mice Mice, Inbred Strains Miscellaneous Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Retention (Psychology) - physiology
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