Noradrenergic modulation of cat area 17 neuronal responses to moving visual stimuli
Orientation and velocity tuning curves were obtained from neurons in cat primary visual cortex before, during and after the iontophoretic application of norepinephrine (NE). While no consistent effects on orientation tuning were observed, the most consistently observed effect of NE on velocity tunin...
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| Veröffentlicht in: | Brain research 1994-12, Vol.667 (1), p.83-97 |
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| creator | McLean, Judith Waterhouse, Barry D. |
| description | Orientation and velocity tuning curves were obtained from neurons in cat primary visual cortex before, during and after the iontophoretic application of norepinephrine (NE). While no consistent effects on orientation tuning were observed, the most consistently observed effect of NE on velocity tuning was enhancement of the selectivity for stimulus speed and direction. This was evidenced by a narrowing of velocity tuning curves in 16/28 of the neurons we encountered as well as by an increase in the measured direction index of 13/28 cells. In contrast to NE, acetylcholine and γ-amino-n-butyric acid (GABA) simply increased and decreased, respectively, the visually-evoked discharges, and in no case altered the shape of the velocity tuning curve. These data suggest that the spatiotemporal tuning of visual cortical neurons may be dependent not only on local interactions between visual afferents and target neurons, but in addition, depend on the activation state of the noradrenergic coeruleo-cortical projection system. |
| doi_str_mv | 10.1016/0006-8993(94)91716-7 |
| format | Article |
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Visual pathways and centers. Vision</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Iontophoresis</topic><topic>Locus Coeruleus - physiology</topic><topic>Neural Inhibition - physiology</topic><topic>Neurons - drug effects</topic><topic>Neurons - physiology</topic><topic>Norepinephrine - pharmacology</topic><topic>Norepinepinehine</topic><topic>Orientation</topic><topic>Orientation selectivity</topic><topic>Photic Stimulation</topic><topic>Velocity selectivity</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Visual cortex</topic><topic>Visual Cortex - drug effects</topic><topic>Visual Cortex - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McLean, Judith</creatorcontrib><creatorcontrib>Waterhouse, Barry D.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McLean, Judith</au><au>Waterhouse, Barry D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Noradrenergic modulation of cat area 17 neuronal responses to moving visual stimuli</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1994-12-19</date><risdate>1994</risdate><volume>667</volume><issue>1</issue><spage>83</spage><epage>97</epage><pages>83-97</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>Orientation and velocity tuning curves were obtained from neurons in cat primary visual cortex before, during and after the iontophoretic application of norepinephrine (NE). 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| subjects | Animals Biological and medical sciences Cat Cats Evoked Potentials, Visual - physiology Eye and associated structures. Visual pathways and centers. Vision Fundamental and applied biological sciences. Psychology Iontophoresis Locus Coeruleus - physiology Neural Inhibition - physiology Neurons - drug effects Neurons - physiology Norepinephrine - pharmacology Norepinepinehine Orientation Orientation selectivity Photic Stimulation Velocity selectivity Vertebrates: nervous system and sense organs Visual cortex Visual Cortex - drug effects Visual Cortex - physiology |
| title | Noradrenergic modulation of cat area 17 neuronal responses to moving visual stimuli |
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