Killer cell inhibitory receptors specific for HLA-C and HLA-B identified by direct binding and by functional transfer
An inhibitory signal is delivered to natural killer (NK) cells and a subset of cytotoxic T cells upon recognition of HLA class 1 molecules on target cells. We demonstrate that soluble forms of killer cell inhibitory receptors (KIR) bind directly and specifically to HLA-C alleles on transfected cells...
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| Veröffentlicht in: | Immunity (Cambridge, Mass.) Mass.), 1995-12, Vol.3 (6), p.801-809 |
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| container_end_page | 809 |
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| container_issue | 6 |
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| container_title | Immunity (Cambridge, Mass.) |
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| creator | Wagtmann, Nicolai Rajagopalan, Sumati Winter, Christine C. Peruui, Marta Long, Eric O. |
| description | An inhibitory signal is delivered to natural killer (NK) cells and a subset of cytotoxic T cells upon recognition of HLA class 1 molecules on target cells. We demonstrate that soluble forms of killer cell inhibitory receptors (KIR) bind directly and specifically to HLA-C alleles on transfected cells. Furthermore, transfer of individual KIR Into NK clones reconstituted recognition of HLA-C on target cells, leading to inhibition of lysis. Using such functional reconstitution, a related KIR that confers specificity for some HLA-B alleles was also identified. These KIR share conserved tyrosine phosphorylation motifs in their cytoplasmic tails. Thus, a single receptor in NK cells provides both specificity for HLA class I on target cells and the Inhibitory signal that prevents lysis. |
| doi_str_mv | 10.1016/1074-7613(95)90069-1 |
| format | Article |
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We demonstrate that soluble forms of killer cell inhibitory receptors (KIR) bind directly and specifically to HLA-C alleles on transfected cells. Furthermore, transfer of individual KIR Into NK clones reconstituted recognition of HLA-C on target cells, leading to inhibition of lysis. Using such functional reconstitution, a related KIR that confers specificity for some HLA-B alleles was also identified. These KIR share conserved tyrosine phosphorylation motifs in their cytoplasmic tails. 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| identifier | ISSN: 1074-7613 |
| ispartof | Immunity (Cambridge, Mass.), 1995-12, Vol.3 (6), p.801-809 |
| issn | 1074-7613 1097-4180 |
| language | eng |
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| source | MEDLINE; Cell Press Free Archives; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ScienceDirect Journals (5 years ago - present) |
| subjects | Alleles Base Sequence Cells, Cultured HLA-B Antigens - genetics HLA-B Antigens - immunology HLA-C Antigens - genetics HLA-C Antigens - immunology Humans Killer Cells, Natural - immunology Molecular Sequence Data Receptors, Immunologic - genetics Receptors, Immunologic - immunology T-Lymphocytes, Cytotoxic - immunology Transfection |
| title | Killer cell inhibitory receptors specific for HLA-C and HLA-B identified by direct binding and by functional transfer |
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