Population pharmacokinetic models : effect of explicit versus assumed constant serum concentration assay error patterns upon parameter values of gentamicin in infants on and off extracorporeal membrane oxygenation

Prior authors had hypothesized (but not clearly found) an increased apparent volume of distribution (Vd) for gentamicin in neonates undergoing extracorporeal membrane oxygenation (ECMO). We chose to study the question in our own clinical setting. To develop population pharmacokinetic models of the d...

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Veröffentlicht in:	Therapeutic drug monitoring 1994-12, Vol.16 (6), p.552-559
Hauptverfasser:	DODGE, W. F, JELLIFFE, R. W, ZWISCHENBERGER, J. B, BELLANGER, R. A, HOKANSON, J. A, SNODGRASS, W. R
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Extracorporeal Membrane Oxygenation Gentamicins - blood Gentamicins - pharmacokinetics Half-Life Humans Infant Infant, Newborn Medical sciences Models, Biological Pharmacology. Drug treatments Population
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