The Mouse Homolog of the Wiskott–Aldrich Syndrome Protein (WASP) Gene Is Highly Conserved and Maps near the Scurfy (sf) Mutation on the X Chromosome

The mouse WASP gene, the homolog of the gene mutated in Wiskott–Aldrich syndrome, has been isolated and sequenced. The predicted amino acid sequence is 86% identical to the human WASP sequence. A distinct feature of the mouse gene is an expanded polymorphic GGA trinucleotide repeat that codes for po...

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Veröffentlicht in:	Genomics 1995-09, Vol.29 (2), p.471-477
Hauptverfasser:	DERRY, JONATHAN M.J., WIEDEMANN, PHILIPP, BLAIR, PATRICK, WANG, YUKER, KERNS, JULIE A., LEMAHIEU, VANESSA, GODFREY, VIRGINIA L., WILKINSON, ERBY J., FRANCKE, UTA
Format:	Artikel
Sprache:	eng
Schlagworte:	AMINO ACID SEQUENCE Animals Base Sequence Biological and medical sciences BIOLOGY AND MEDICINE, BASIC STUDIES Chromosome Mapping Classical genetics, quantitative genetics, hybrids Crosses, Genetic DNA SEQUENCING EXONS Female Fundamental and applied biological sciences. Psychology GENES Genetic Linkage GENETIC MAPPING Genetics of eukaryotes. Biological and molecular evolution Genomic Library HEREDITARY DISEASES Humans HYBRIDIZATION IMMUNE SYSTEM DISEASES INTRONS Male MICE Mice, Inbred Strains - genetics Molecular Sequence Data NUCLEOTIDES POLYMERASE CHAIN REACTION PROBES PROTEINS Proteins - chemistry Proteins - genetics Sequence Homology, Amino Acid Sequence Homology, Nucleic Acid STRUCTURE-ACTIVITY RELATIONSHIPS Vertebrata Wiskott-Aldrich Syndrome - genetics Wiskott-Aldrich Syndrome Protein X CHROMOSOME
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