Importance of T-cell-dependent inflammatory reactions in the decline of microsomal cytochrome P450 concentration in the livers of rats infected with Fasciola hepatica

The concentration of cytochrome P450, measured spectrophotometrically in microsomal preparations from the livers of rats infected with 30 metacercariae of Fasciola hepatica, declined by approximately 50% at 3 weeks post-infection. Treatment of infected rats with the anti-inflammatory agent dexametha...

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Veröffentlicht in:	International journal for parasitology 1995-10, Vol.25 (10), p.1259-1262
Hauptverfasser:	Topfer, Fiona, Lenton, Linda M., Bygrave, Fyfe L., Behm, Carolyn A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacology athymic rats Biological and medical sciences Cytochrome P-450 Enzyme System - metabolism dexamethasone Dexamethasone - pharmacology drug metabolism Fasciola hepatica Fascioliasis - enzymology Fascioliasis - immunology Helminthic diseases Infectious diseases inflammation Inflammation - immunology liver fluke liver metabolism Male Medical sciences Microsomes, Liver - enzymology Microsomes, Liver - immunology Miscellaneous P450 Parasitic diseases Rats Rats, Inbred Lew Rats, Nude Rats, Wistar T-Lymphocytes - immunology trematode
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