Prognostic factors for local control, regional control and survival in oropharyngeal squamous cell carcinoma
We have performed univariate and multivariate analysis to identify the clinical and treatment-related prognostic factors in a series of 254 patients with newly diagnosed, histologically proven, oropharyngeal squamous cell carcinoma treated with radical radiation therapy. The probabilities of local c...
Gespeichert in:
| Veröffentlicht in: | European journal of cancer (1990) 1994, Vol.30 (14), p.2060-2067 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2067 |
|---|---|
| container_issue | 14 |
| container_start_page | 2060 |
| container_title | European journal of cancer (1990) |
| container_volume | 30 |
| creator | Regueiro, C.A. Aragón, G. Millán, L Valcárcel, F.J. de la Torre, A. Magallón, R. |
| description | We have performed univariate and multivariate analysis to identify the clinical and treatment-related prognostic factors in a series of 254 patients with newly diagnosed, histologically proven, oropharyngeal squamous cell carcinoma treated with radical radiation therapy. The probabilities of local control, regional control, disease-free survival (DFS) and adjusted survival (AS) were calculated using the Kaplan-Meier method and differences between curves were evaluated by the Mantel-Cox test. The obtained significant variables in the univariate analysis were analysed using the Cox proportional hazards model. In the Cox multivariate analysis, four variables significantly influenced local control probability in the following order: tumour diameter, N stage, alcohol intake and weight loss. N stage significantly influenced the probability of regional control. Five variables influenced both DFS and AS: N stage, tumour diameter, weight loss, alcohol intake and tumour origin within the posterior oropharyngeal wall. |
| doi_str_mv | 10.1016/0959-8049(94)00348-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_77770372</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0959804994003489</els_id><sourcerecordid>77770372</sourcerecordid><originalsourceid>FETCH-LOGICAL-c423t-2fde40720001b246a19f6c0ef4df079aeaee2657bbd6b2c19505016a76261a783</originalsourceid><addsrcrecordid>eNp9kEFrGzEQhUVJcBy3_6AFnUIC3XQka1erSyCEtAkY0kNzFlrtrKuyKznSriH_PnJsnFt1EbyZN_PmI-Qrg2sGrPoBqlRFDUJdKnEFsBR1oT6ROaulKqAu-QmZH1vOyHlK_wBA1gJmZCbrUkoQc9L_jmHtQxqdpZ2xY4iJdiHSPljTUxv8GEP_nUZcu-A_FGp8S9MUt26bRedpiGHz18RXv8YspJfJDGFK1GKfPSZa58NgPpPTzvQJvxz-BXn-ef_n7qFYPf16vLtdFVbw5VjwrkUBkue4rOGiMkx1lQXsRNuBVAYNIq9K2TRt1XDLVAllBmJkxStmZL1ckIv93E0MLxOmUQ8u7aIYjzmVlvnBUvLcKPaNNoaUInZ6E92Qz9AM9A6y3hHUO4JaCf0OWats-3aYPzUDtkfTgWqu3-zrmI_cOow6WYfeYusi2lG3wf1_wRswAY2X</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>77770372</pqid></control><display><type>article</type><title>Prognostic factors for local control, regional control and survival in oropharyngeal squamous cell carcinoma</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Regueiro, C.A. ; Aragón, G. ; Millán, L ; Valcárcel, F.J. ; de la Torre, A. ; Magallón, R.</creator><creatorcontrib>Regueiro, C.A. ; Aragón, G. ; Millán, L ; Valcárcel, F.J. ; de la Torre, A. ; Magallón, R.</creatorcontrib><description>We have performed univariate and multivariate analysis to identify the clinical and treatment-related prognostic factors in a series of 254 patients with newly diagnosed, histologically proven, oropharyngeal squamous cell carcinoma treated with radical radiation therapy. The probabilities of local control, regional control, disease-free survival (DFS) and adjusted survival (AS) were calculated using the Kaplan-Meier method and differences between curves were evaluated by the Mantel-Cox test. The obtained significant variables in the univariate analysis were analysed using the Cox proportional hazards model. In the Cox multivariate analysis, four variables significantly influenced local control probability in the following order: tumour diameter, N stage, alcohol intake and weight loss. N stage significantly influenced the probability of regional control. Five variables influenced both DFS and AS: N stage, tumour diameter, weight loss, alcohol intake and tumour origin within the posterior oropharyngeal wall.</description><identifier>ISSN: 0959-8049</identifier><identifier>EISSN: 1879-0852</identifier><identifier>DOI: 10.1016/0959-8049(94)00348-9</identifier><identifier>PMID: 7857704</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; alcohol ; Alcohol Drinking ; carcinoma ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - radiotherapy ; Disease-Free Survival ; Female ; Humans ; Male ; Middle Aged ; Multivariate Analysis ; Oropharyngeal Neoplasms - mortality ; Oropharyngeal Neoplasms - radiotherapy ; oropharynx ; Prognosis ; prognostic factors ; Proportional Hazards Models ; Survival Analysis ; Weight Loss</subject><ispartof>European journal of cancer (1990), 1994, Vol.30 (14), p.2060-2067</ispartof><rights>1994</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-2fde40720001b246a19f6c0ef4df079aeaee2657bbd6b2c19505016a76261a783</citedby><cites>FETCH-LOGICAL-c423t-2fde40720001b246a19f6c0ef4df079aeaee2657bbd6b2c19505016a76261a783</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0959-8049(94)00348-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,4022,27922,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7857704$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Regueiro, C.A.</creatorcontrib><creatorcontrib>Aragón, G.</creatorcontrib><creatorcontrib>Millán, L</creatorcontrib><creatorcontrib>Valcárcel, F.J.</creatorcontrib><creatorcontrib>de la Torre, A.</creatorcontrib><creatorcontrib>Magallón, R.</creatorcontrib><title>Prognostic factors for local control, regional control and survival in oropharyngeal squamous cell carcinoma</title><title>European journal of cancer (1990)</title><addtitle>Eur J Cancer</addtitle><description>We have performed univariate and multivariate analysis to identify the clinical and treatment-related prognostic factors in a series of 254 patients with newly diagnosed, histologically proven, oropharyngeal squamous cell carcinoma treated with radical radiation therapy. The probabilities of local control, regional control, disease-free survival (DFS) and adjusted survival (AS) were calculated using the Kaplan-Meier method and differences between curves were evaluated by the Mantel-Cox test. The obtained significant variables in the univariate analysis were analysed using the Cox proportional hazards model. In the Cox multivariate analysis, four variables significantly influenced local control probability in the following order: tumour diameter, N stage, alcohol intake and weight loss. N stage significantly influenced the probability of regional control. Five variables influenced both DFS and AS: N stage, tumour diameter, weight loss, alcohol intake and tumour origin within the posterior oropharyngeal wall.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>alcohol</subject><subject>Alcohol Drinking</subject><subject>carcinoma</subject><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Carcinoma, Squamous Cell - radiotherapy</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Oropharyngeal Neoplasms - mortality</subject><subject>Oropharyngeal Neoplasms - radiotherapy</subject><subject>oropharynx</subject><subject>Prognosis</subject><subject>prognostic factors</subject><subject>Proportional Hazards Models</subject><subject>Survival Analysis</subject><subject>Weight Loss</subject><issn>0959-8049</issn><issn>1879-0852</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFrGzEQhUVJcBy3_6AFnUIC3XQka1erSyCEtAkY0kNzFlrtrKuyKznSriH_PnJsnFt1EbyZN_PmI-Qrg2sGrPoBqlRFDUJdKnEFsBR1oT6ROaulKqAu-QmZH1vOyHlK_wBA1gJmZCbrUkoQc9L_jmHtQxqdpZ2xY4iJdiHSPljTUxv8GEP_nUZcu-A_FGp8S9MUt26bRedpiGHz18RXv8YspJfJDGFK1GKfPSZa58NgPpPTzvQJvxz-BXn-ef_n7qFYPf16vLtdFVbw5VjwrkUBkue4rOGiMkx1lQXsRNuBVAYNIq9K2TRt1XDLVAllBmJkxStmZL1ckIv93E0MLxOmUQ8u7aIYjzmVlvnBUvLcKPaNNoaUInZ6E92Qz9AM9A6y3hHUO4JaCf0OWats-3aYPzUDtkfTgWqu3-zrmI_cOow6WYfeYusi2lG3wf1_wRswAY2X</recordid><startdate>1994</startdate><enddate>1994</enddate><creator>Regueiro, C.A.</creator><creator>Aragón, G.</creator><creator>Millán, L</creator><creator>Valcárcel, F.J.</creator><creator>de la Torre, A.</creator><creator>Magallón, R.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1994</creationdate><title>Prognostic factors for local control, regional control and survival in oropharyngeal squamous cell carcinoma</title><author>Regueiro, C.A. ; Aragón, G. ; Millán, L ; Valcárcel, F.J. ; de la Torre, A. ; Magallón, R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-2fde40720001b246a19f6c0ef4df079aeaee2657bbd6b2c19505016a76261a783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>alcohol</topic><topic>Alcohol Drinking</topic><topic>carcinoma</topic><topic>Carcinoma, Squamous Cell - mortality</topic><topic>Carcinoma, Squamous Cell - radiotherapy</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Oropharyngeal Neoplasms - mortality</topic><topic>Oropharyngeal Neoplasms - radiotherapy</topic><topic>oropharynx</topic><topic>Prognosis</topic><topic>prognostic factors</topic><topic>Proportional Hazards Models</topic><topic>Survival Analysis</topic><topic>Weight Loss</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Regueiro, C.A.</creatorcontrib><creatorcontrib>Aragón, G.</creatorcontrib><creatorcontrib>Millán, L</creatorcontrib><creatorcontrib>Valcárcel, F.J.</creatorcontrib><creatorcontrib>de la Torre, A.</creatorcontrib><creatorcontrib>Magallón, R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of cancer (1990)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Regueiro, C.A.</au><au>Aragón, G.</au><au>Millán, L</au><au>Valcárcel, F.J.</au><au>de la Torre, A.</au><au>Magallón, R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic factors for local control, regional control and survival in oropharyngeal squamous cell carcinoma</atitle><jtitle>European journal of cancer (1990)</jtitle><addtitle>Eur J Cancer</addtitle><date>1994</date><risdate>1994</risdate><volume>30</volume><issue>14</issue><spage>2060</spage><epage>2067</epage><pages>2060-2067</pages><issn>0959-8049</issn><eissn>1879-0852</eissn><abstract>We have performed univariate and multivariate analysis to identify the clinical and treatment-related prognostic factors in a series of 254 patients with newly diagnosed, histologically proven, oropharyngeal squamous cell carcinoma treated with radical radiation therapy. The probabilities of local control, regional control, disease-free survival (DFS) and adjusted survival (AS) were calculated using the Kaplan-Meier method and differences between curves were evaluated by the Mantel-Cox test. The obtained significant variables in the univariate analysis were analysed using the Cox proportional hazards model. In the Cox multivariate analysis, four variables significantly influenced local control probability in the following order: tumour diameter, N stage, alcohol intake and weight loss. N stage significantly influenced the probability of regional control. Five variables influenced both DFS and AS: N stage, tumour diameter, weight loss, alcohol intake and tumour origin within the posterior oropharyngeal wall.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>7857704</pmid><doi>10.1016/0959-8049(94)00348-9</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0959-8049 |
| ispartof | European journal of cancer (1990), 1994, Vol.30 (14), p.2060-2067 |
| issn | 0959-8049 1879-0852 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77770372 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adolescent Adult Aged Aged, 80 and over alcohol Alcohol Drinking carcinoma Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - radiotherapy Disease-Free Survival Female Humans Male Middle Aged Multivariate Analysis Oropharyngeal Neoplasms - mortality Oropharyngeal Neoplasms - radiotherapy oropharynx Prognosis prognostic factors Proportional Hazards Models Survival Analysis Weight Loss |
| title | Prognostic factors for local control, regional control and survival in oropharyngeal squamous cell carcinoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-10T12%3A55%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prognostic%20factors%20for%20local%20control,%20regional%20control%20and%20survival%20in%20oropharyngeal%20squamous%20cell%20carcinoma&rft.jtitle=European%20journal%20of%20cancer%20(1990)&rft.au=Regueiro,%20C.A.&rft.date=1994&rft.volume=30&rft.issue=14&rft.spage=2060&rft.epage=2067&rft.pages=2060-2067&rft.issn=0959-8049&rft.eissn=1879-0852&rft_id=info:doi/10.1016/0959-8049(94)00348-9&rft_dat=%3Cproquest_cross%3E77770372%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=77770372&rft_id=info:pmid/7857704&rft_els_id=0959804994003489&rfr_iscdi=true |