Melatonin stimulates brain glutathione peroxidase activity
Exogenously administered melatonin causes a 2-fold rise in glutathione peroxidase activity within 30 min in the brain of the rat. Furthermore, brain glutathione peroxidase activity is higher at night than during the day and is correlated with high night-time tissue melatonin levels. Glutathione pero...
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| Veröffentlicht in: | Neurochemistry international 1995-05, Vol.26 (5), p.497-502 |
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| container_title | Neurochemistry international |
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| creator | Barlow-Walden, L.R. Reiter, R.J. Abe, M. Pablos, M. Menendez-Pelaez, A. Chen, L.-D. Poeggeler, B. |
| description | Exogenously administered melatonin causes a 2-fold rise in glutathione peroxidase activity within 30 min in the brain of the rat. Furthermore, brain glutathione peroxidase activity is higher at night than during the day and is correlated with high night-time tissue melatonin levels. Glutathione peroxidase is thought to be the principal enzyme eliminating peroxides in the brain. This antioxidative enzyme reduces the formation of hydroxyl radicals formed via iron-catalyzed Fenton-type reactions from hydrogen peroxide by reducing this oxidant to water. Since the hydroxyl radical is the most noxious oxygen radical known, induction of brain glutathione peroxidase might be an important mechanism by which melatonin exerts its potent neuroprotective effects. |
| doi_str_mv | 10.1016/0197-0186(94)00154-M |
| format | Article |
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Furthermore, brain glutathione peroxidase activity is higher at night than during the day and is correlated with high night-time tissue melatonin levels. Glutathione peroxidase is thought to be the principal enzyme eliminating peroxides in the brain. This antioxidative enzyme reduces the formation of hydroxyl radicals formed via iron-catalyzed Fenton-type reactions from hydrogen peroxide by reducing this oxidant to water. 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Furthermore, brain glutathione peroxidase activity is higher at night than during the day and is correlated with high night-time tissue melatonin levels. Glutathione peroxidase is thought to be the principal enzyme eliminating peroxides in the brain. This antioxidative enzyme reduces the formation of hydroxyl radicals formed via iron-catalyzed Fenton-type reactions from hydrogen peroxide by reducing this oxidant to water. Since the hydroxyl radical is the most noxious oxygen radical known, induction of brain glutathione peroxidase might be an important mechanism by which melatonin exerts its potent neuroprotective effects.</description><subject>Animals</subject><subject>Biochemistry and metabolism</subject><subject>Biological and medical sciences</subject><subject>Brain - drug effects</subject><subject>Brain - enzymology</subject><subject>Central nervous system</subject><subject>Female</subject><subject>Free Radical Scavengers - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glutathione Peroxidase - drug effects</subject><subject>Hydroxyl Radical</subject><subject>Melatonin - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Stimulation, Chemical</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0197-0186</issn><issn>1872-9754</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEFP2zAUx60JBKXsGwypBzTBIew5sWObw6Sp2gCp1S7sbL049jBKk852Kvrtl6xRj8OXJ_v93l9-P0I-UbijQMsvQJXIgMryRrFbAMpZtv5AZlSKPFOCsxMyOyLn5CLGVwAQCvgZORNM5YqJGblf2wZT1_p2EZPf9MPFxkUVcHj43fQJ04vvWrvY2tC9-RqjXaBJfufT_pKcOmyi_TjVOfn14_vz8jFb_Xx4Wn5bZYaVMmVSAWOOKVS8Vk7UwjmFYLh0QjoUJq8Zr6SraO6UUrJGaUrOKaKEnEMFxZx8PuRuQ_entzHpjY_GNg22tuujFsMZdpTvgrSUZQH5mMgOoAldjME6vQ1-g2GvKejRrR7F6VGcVkz_c6vXw9jVlN9XG1sfhyaZQ_966mM02LiArfHxiBW8kIUcsa8HzA7Sdt4GHY23rbG1D9YkXXf-___4C3QelU4</recordid><startdate>19950501</startdate><enddate>19950501</enddate><creator>Barlow-Walden, L.R.</creator><creator>Reiter, R.J.</creator><creator>Abe, M.</creator><creator>Pablos, M.</creator><creator>Menendez-Pelaez, A.</creator><creator>Chen, L.-D.</creator><creator>Poeggeler, B.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19950501</creationdate><title>Melatonin stimulates brain glutathione peroxidase activity</title><author>Barlow-Walden, L.R. ; Reiter, R.J. ; Abe, M. ; Pablos, M. ; Menendez-Pelaez, A. ; Chen, L.-D. ; Poeggeler, B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-89044f49a95d9f7d7ff9a0c58f78fa7c2d45b8fb12f9998da8c6551aa80250b03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Animals</topic><topic>Biochemistry and metabolism</topic><topic>Biological and medical sciences</topic><topic>Brain - drug effects</topic><topic>Brain - enzymology</topic><topic>Central nervous system</topic><topic>Female</topic><topic>Free Radical Scavengers - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glutathione Peroxidase - drug effects</topic><topic>Hydroxyl Radical</topic><topic>Melatonin - pharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Stimulation, Chemical</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barlow-Walden, L.R.</creatorcontrib><creatorcontrib>Reiter, R.J.</creatorcontrib><creatorcontrib>Abe, M.</creatorcontrib><creatorcontrib>Pablos, M.</creatorcontrib><creatorcontrib>Menendez-Pelaez, A.</creatorcontrib><creatorcontrib>Chen, L.-D.</creatorcontrib><creatorcontrib>Poeggeler, B.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neurochemistry international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barlow-Walden, L.R.</au><au>Reiter, R.J.</au><au>Abe, M.</au><au>Pablos, M.</au><au>Menendez-Pelaez, A.</au><au>Chen, L.-D.</au><au>Poeggeler, B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Melatonin stimulates brain glutathione peroxidase activity</atitle><jtitle>Neurochemistry international</jtitle><addtitle>Neurochem Int</addtitle><date>1995-05-01</date><risdate>1995</risdate><volume>26</volume><issue>5</issue><spage>497</spage><epage>502</epage><pages>497-502</pages><issn>0197-0186</issn><eissn>1872-9754</eissn><coden>NEUIDS</coden><abstract>Exogenously administered melatonin causes a 2-fold rise in glutathione peroxidase activity within 30 min in the brain of the rat. 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| ispartof | Neurochemistry international, 1995-05, Vol.26 (5), p.497-502 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biochemistry and metabolism Biological and medical sciences Brain - drug effects Brain - enzymology Central nervous system Female Free Radical Scavengers - pharmacology Fundamental and applied biological sciences. Psychology Glutathione Peroxidase - drug effects Hydroxyl Radical Melatonin - pharmacology Rats Rats, Sprague-Dawley Stimulation, Chemical Vertebrates: nervous system and sense organs |
| title | Melatonin stimulates brain glutathione peroxidase activity |
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