Novel tyvelose-containing tri- and tetra-antennary N-glycans in the immunodominant antigens of the intracellular parasite Trichinella spiralis

The larval stage of the intestinal nematode, Trichinella spiralis, secretes and displays on its cuticle a number of antigenically cross-reactive giycoproteins. These so-called TSL–1 antigens induce a powerful antibody response hi parasitized animals. In rats, anti-TSL-1 antibodies mediate a protecti...

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Veröffentlicht in:	Glycobiology (Oxford) 1994-10, Vol.4 (5), p.593-603
Hauptverfasser:	Reason, Andrew J., Ellis, Lauri A., Appleton, Judith A., Wisnewski, Nancy, Grieve, Robert B., McNeil, Michael, Wassom, Donald L., Morris, Howard R, Dell, Anne
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Helminth - immunology Carbohydrate Conformation Carbohydrate Sequence FAB-MS Glycoside Hydrolases Hexoses - chemistry Hydrolysis immunodominant antigens Immunodominant Epitopes - chemistry Immunodominant Epitopes - immunology Molecular Sequence Data N-glycans Polysaccharides - analysis Polysaccharides - immunology Spectrometry, Mass, Fast Atom Bombardment Stereoisomerism Trichinella spiralis Trichinella spiralis - immunology tyvelose
Online-Zugang:	Volltext
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