A genetic test of the effects of mutations in PKA on mossy fiber ltp and its relation to spatial and contextual learning

Using a genetic approach, we assessed the effects of mutations in protein kinase A (PKA) on long-term potentiation (LTP) in the mossy fiber pathway and its relationship to spatial and contextual learning. Ablation by gene targeting of the Cβ1 or the RIβ isoform of PKA produces a selective defect in...

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Veröffentlicht in:	Cell 1995-12, Vol.83 (7), p.1211-1222
Hauptverfasser:	Huang, Yan-You, Kandel, Eric R., Varshavsky, Lauren, Brandont, Eugene P., Qi, Ming, Idzerda, Rejean L., Stanley McKnight, G., Bourtchouladz, Roussoudan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Colforsin - pharmacology Conditioning (Psychology) - physiology Cyclic AMP-Dependent Protein Kinase RIbeta Subunit Cyclic AMP-Dependent Protein Kinases - genetics Cyclic AMP-Dependent Protein Kinases - metabolism Electrophysiology Female Hippocampus - cytology Hippocampus - physiology Isoenzymes Isoproterenol - pharmacology Long-Term Potentiation - genetics Male Maze Learning - physiology Mice Mice, Inbred C57BL Mice, Knockout Mutation Spatial Behavior - physiology
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