Dissociation of Behavioral Changes in Rats Resulting From Lesions of the Habenula Versus Fasciculus Retroflexus and Their Possible Anatomical Substrates
Lesions in either the habenula or its primary efferent pathway, the fasciculus retroflexus (FR), impaired avoidance responding. However, lesions of only the FR provided a persistent elevation of locomotor activity. Immunocytochemical study of the interpeduncular nucleus (IPN) through injection of re...
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| Veröffentlicht in: | Behavioral neuroscience 1994-12, Vol.108 (6), p.1150-1162 |
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| creator | Thornton, Everard W Murray, Marion Connors-Eckenrode, Theresa Haun, Forrest |
| description | Lesions in either the habenula or its primary efferent pathway, the fasciculus retroflexus (FR), impaired avoidance responding. However, lesions of only the FR provided a persistent elevation of locomotor activity. Immunocytochemical study of the interpeduncular nucleus (IPN) through injection of retrograde tracers into the IPN and the overlying ventral tegmental area indicated that habenular lesions spared both rostral habenula and forebrain projections to the caudal midbrain, but these projections were axotomized by FR lesions. Rostral sparing of the habenula resulted in normal peptidergic staining in the IPN, and normal cholinergic innervation was absent. Performance of individual rats in behavioral tests was consistent with variations in anatomical sparing. Such considerations may account for previous discrepancies in functional effects of habenular lesions. |
| doi_str_mv | 10.1037/0735-7044.108.6.1150 |
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However, lesions of only the FR provided a persistent elevation of locomotor activity. Immunocytochemical study of the interpeduncular nucleus (IPN) through injection of retrograde tracers into the IPN and the overlying ventral tegmental area indicated that habenular lesions spared both rostral habenula and forebrain projections to the caudal midbrain, but these projections were axotomized by FR lesions. Rostral sparing of the habenula resulted in normal peptidergic staining in the IPN, and normal cholinergic innervation was absent. Performance of individual rats in behavioral tests was consistent with variations in anatomical sparing. Such considerations may account for previous discrepancies in functional effects of habenular lesions.</description><identifier>ISSN: 0735-7044</identifier><identifier>EISSN: 1939-0084</identifier><identifier>DOI: 10.1037/0735-7044.108.6.1150</identifier><identifier>PMID: 7893407</identifier><language>eng</language><publisher>United States: American Psychological Association</publisher><subject>Activity Level ; Animal ; Animal behavior ; Animal Open Field Behavior ; Animals ; Avoidance Conditioning ; Avoidance Learning - physiology ; Axons - physiology ; Brain ; Brain Mapping ; Brain Stem - physiology ; Cholinergic Fibers - physiology ; Efferent Pathways ; Efferent Pathways - physiology ; Electroshock ; Escape Reaction - physiology ; Hypothalamic Area, Lateral - physiology ; Immunohistochemistry ; Male ; Motor Activity - physiology ; Neural Inhibition - physiology ; Neural Lesions ; Neurons - physiology ; Neuropeptides - physiology ; Raphe Nuclei - physiology ; Rats ; Rats, Wistar ; Reaction Time - physiology ; Rodents ; Substantia Nigra - physiology ; Thalamic Nuclei - physiology ; Ventral Tegmental Area - physiology</subject><ispartof>Behavioral neuroscience, 1994-12, Vol.108 (6), p.1150-1162</ispartof><rights>1994 American Psychological Association</rights><rights>Copyright American Psychological Association Dec 1994</rights><rights>1994, American Psychological Association</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a485t-5ceb76daaa7509202c3b49d050478f0bd923c10a431d98c4e6a82471d508363c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7893407$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Squire, Larry R</contributor><creatorcontrib>Thornton, Everard W</creatorcontrib><creatorcontrib>Murray, Marion</creatorcontrib><creatorcontrib>Connors-Eckenrode, Theresa</creatorcontrib><creatorcontrib>Haun, Forrest</creatorcontrib><title>Dissociation of Behavioral Changes in Rats Resulting From Lesions of the Habenula Versus Fasciculus Retroflexus and Their Possible Anatomical Substrates</title><title>Behavioral neuroscience</title><addtitle>Behav Neurosci</addtitle><description>Lesions in either the habenula or its primary efferent pathway, the fasciculus retroflexus (FR), impaired avoidance responding. However, lesions of only the FR provided a persistent elevation of locomotor activity. Immunocytochemical study of the interpeduncular nucleus (IPN) through injection of retrograde tracers into the IPN and the overlying ventral tegmental area indicated that habenular lesions spared both rostral habenula and forebrain projections to the caudal midbrain, but these projections were axotomized by FR lesions. Rostral sparing of the habenula resulted in normal peptidergic staining in the IPN, and normal cholinergic innervation was absent. Performance of individual rats in behavioral tests was consistent with variations in anatomical sparing. Such considerations may account for previous discrepancies in functional effects of habenular lesions.</description><subject>Activity Level</subject><subject>Animal</subject><subject>Animal behavior</subject><subject>Animal Open Field Behavior</subject><subject>Animals</subject><subject>Avoidance Conditioning</subject><subject>Avoidance Learning - physiology</subject><subject>Axons - physiology</subject><subject>Brain</subject><subject>Brain Mapping</subject><subject>Brain Stem - physiology</subject><subject>Cholinergic Fibers - physiology</subject><subject>Efferent Pathways</subject><subject>Efferent Pathways - physiology</subject><subject>Electroshock</subject><subject>Escape Reaction - physiology</subject><subject>Hypothalamic Area, Lateral - physiology</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Motor Activity - physiology</subject><subject>Neural Inhibition - physiology</subject><subject>Neural Lesions</subject><subject>Neurons - physiology</subject><subject>Neuropeptides - physiology</subject><subject>Raphe Nuclei - physiology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reaction Time - physiology</subject><subject>Rodents</subject><subject>Substantia Nigra - physiology</subject><subject>Thalamic Nuclei - physiology</subject><subject>Ventral Tegmental Area - physiology</subject><issn>0735-7044</issn><issn>1939-0084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFksFu1DAQhiMEKkvhDUCyOPSWxY6dODmWLUuRVgKVwtWaOE7XVdZePDaib8Lj4rCrSlQILrZH8_3_2J4pipeMLhnl8g2VvC4lFSKH7bJZMlbTR8WCdbwrKW3F42JxjzwtniHeUkoFFfVJcSLbjgsqF8XPC4votYVovSN-JG_NFr5bH2Aiqy24G4PEOnIFEcmVwTRF627IOvgd2RjMGpxFcWvIJfTGpQnIVxMwIVkDaqvTlGZhDH6czI98BjeQ662xgXzyiLafDDl3EP3O6lzyc-oxBogGnxdPRpjQvDjup8WX9bvr1WW5-fj-w-p8U4Jo61jW2vSyGQBA1rSraKV5L7qB1lTIdqT90FVcMwqCs6FrtTANtJWQbKhpyxuu-WlxdvDdB_8tGYxqZ1GbaQJnfEIlpWxaIbv_gqyRlRB0Bl8_AG99Ci4_QjVMcC5FXv8BVZR3-f6_S4oDpEP-q2BGtQ92B-FOMarmGVBzg9Xc4By2qlHzDGTZq6N36ndmuBcdm57z5SEPe1B7vNMQotWTQZ1CMC6q3pk__c7-zj8EfwFO9cmt</recordid><startdate>19941201</startdate><enddate>19941201</enddate><creator>Thornton, Everard W</creator><creator>Murray, Marion</creator><creator>Connors-Eckenrode, Theresa</creator><creator>Haun, Forrest</creator><general>American Psychological Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7RZ</scope><scope>PSYQQ</scope><scope>7X8</scope></search><sort><creationdate>19941201</creationdate><title>Dissociation of Behavioral Changes in Rats Resulting From Lesions of the Habenula Versus Fasciculus Retroflexus and Their Possible Anatomical Substrates</title><author>Thornton, Everard W ; Murray, Marion ; Connors-Eckenrode, Theresa ; Haun, Forrest</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a485t-5ceb76daaa7509202c3b49d050478f0bd923c10a431d98c4e6a82471d508363c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Activity Level</topic><topic>Animal</topic><topic>Animal behavior</topic><topic>Animal Open Field Behavior</topic><topic>Animals</topic><topic>Avoidance Conditioning</topic><topic>Avoidance Learning - physiology</topic><topic>Axons - physiology</topic><topic>Brain</topic><topic>Brain Mapping</topic><topic>Brain Stem - physiology</topic><topic>Cholinergic Fibers - physiology</topic><topic>Efferent Pathways</topic><topic>Efferent Pathways - physiology</topic><topic>Electroshock</topic><topic>Escape Reaction - physiology</topic><topic>Hypothalamic Area, Lateral - physiology</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Motor Activity - physiology</topic><topic>Neural Inhibition - physiology</topic><topic>Neural Lesions</topic><topic>Neurons - physiology</topic><topic>Neuropeptides - physiology</topic><topic>Raphe Nuclei - physiology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Reaction Time - physiology</topic><topic>Rodents</topic><topic>Substantia Nigra - physiology</topic><topic>Thalamic Nuclei - physiology</topic><topic>Ventral Tegmental Area - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thornton, Everard W</creatorcontrib><creatorcontrib>Murray, Marion</creatorcontrib><creatorcontrib>Connors-Eckenrode, Theresa</creatorcontrib><creatorcontrib>Haun, Forrest</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>APA PsycArticles®</collection><collection>ProQuest One Psychology</collection><collection>MEDLINE - Academic</collection><jtitle>Behavioral neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thornton, Everard W</au><au>Murray, Marion</au><au>Connors-Eckenrode, Theresa</au><au>Haun, Forrest</au><au>Squire, Larry R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dissociation of Behavioral Changes in Rats Resulting From Lesions of the Habenula Versus Fasciculus Retroflexus and Their Possible Anatomical Substrates</atitle><jtitle>Behavioral neuroscience</jtitle><addtitle>Behav Neurosci</addtitle><date>1994-12-01</date><risdate>1994</risdate><volume>108</volume><issue>6</issue><spage>1150</spage><epage>1162</epage><pages>1150-1162</pages><issn>0735-7044</issn><eissn>1939-0084</eissn><abstract>Lesions in either the habenula or its primary efferent pathway, the fasciculus retroflexus (FR), impaired avoidance responding. However, lesions of only the FR provided a persistent elevation of locomotor activity. Immunocytochemical study of the interpeduncular nucleus (IPN) through injection of retrograde tracers into the IPN and the overlying ventral tegmental area indicated that habenular lesions spared both rostral habenula and forebrain projections to the caudal midbrain, but these projections were axotomized by FR lesions. Rostral sparing of the habenula resulted in normal peptidergic staining in the IPN, and normal cholinergic innervation was absent. Performance of individual rats in behavioral tests was consistent with variations in anatomical sparing. Such considerations may account for previous discrepancies in functional effects of habenular lesions.</abstract><cop>United States</cop><pub>American Psychological Association</pub><pmid>7893407</pmid><doi>10.1037/0735-7044.108.6.1150</doi><tpages>13</tpages></addata></record> |
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| subjects | Activity Level Animal Animal behavior Animal Open Field Behavior Animals Avoidance Conditioning Avoidance Learning - physiology Axons - physiology Brain Brain Mapping Brain Stem - physiology Cholinergic Fibers - physiology Efferent Pathways Efferent Pathways - physiology Electroshock Escape Reaction - physiology Hypothalamic Area, Lateral - physiology Immunohistochemistry Male Motor Activity - physiology Neural Inhibition - physiology Neural Lesions Neurons - physiology Neuropeptides - physiology Raphe Nuclei - physiology Rats Rats, Wistar Reaction Time - physiology Rodents Substantia Nigra - physiology Thalamic Nuclei - physiology Ventral Tegmental Area - physiology |
| title | Dissociation of Behavioral Changes in Rats Resulting From Lesions of the Habenula Versus Fasciculus Retroflexus and Their Possible Anatomical Substrates |
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