Effect of Levomepromazine and Metabolites on Debrisoquine Hydroxylation in the Rat

: The influence of the major metabolites of the phenothiazine derivative, levomepromazine (methotrimeprazine), on hydroxylation of debrisoquine was examined in male Sprague‐Dawley rats. The metabolic ratio of debrisoquine/4‐hydroxy debrisoquine was first determined in rats after oral administration...

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Veröffentlicht in:	Pharmacology & toxicology 1994-11, Vol.75 (3‐4), p.255-260
Hauptverfasser:	Hals, Petter‐Amt, Dahl, Svein G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Biological and medical sciences Chromatography, High Pressure Liquid Cytochrome P-450 Enzyme System - metabolism Debrisoquin - administration & dosage Debrisoquin - metabolism Dose-Response Relationship, Drug Drug Combinations General pharmacology Hydroxylation - drug effects Male Medical sciences Methotrimeprazine - analogs & derivatives Methotrimeprazine - pharmacology Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Rats Rats, Sprague-Dawley
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