Cytochalisin D exerts stimulatory and inhibitory effects on insulin-induced glucokinase mRNA expression in hepatocytes

The microfilament cytoskeleton is postulated to have a role in the localization, transport and anchorage of certain specific mRNAs. We investigated the effects of cytochalasin D, a fungal metabolite that binds to actin and disrupts the microfilament structure, on insulin-induced expression of glucok...

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Veröffentlicht in:	Molecular and cellular biochemistry 1994-10, Vol.139 (2), p.177-184
Hauptverfasser:	Beresford, G W, Agius, L
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - genetics Albumins - genetics Animals Cells, Cultured Cytochalasin D - pharmacology Cytoskeleton - drug effects Cytoskeleton - metabolism Digitonin - pharmacology DNA, Complementary Gene Expression Regulation Glucokinase - biosynthesis Glucokinase - genetics Glucokinase - metabolism Insulin - pharmacology Liver - cytology Liver - metabolism Male Radioisotopes Rats Rats, Wistar RNA Processing, Post-Transcriptional RNA, Messenger - genetics RNA, Messenger - metabolism Tubulin - genetics
Online-Zugang:	Volltext
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