Cloning and expression of a human large-conductance calcium-activated potassium channel

A putative BK channel gene was cloned from a human brain (substantia nigra) cDNA library by hybridization screening. The sequence of the full length clone shows high homology with the mSlo gene, suggesting that this cDNA is the human homologue ( hSlo). The hSlo clone does not contain either alternat...

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Veröffentlicht in:	Brain research. Molecular brain research. 1994-11, Vol.27 (1), p.189-193
Hauptverfasser:	Dworetzky, Steven I., Trojnacki, Joanne T., Gribkoff, Valentin K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Base Sequence BK channel Brain Chemistry Calcium - physiology Cloning Cloning, Molecular DNA, Complementary - genetics Exons Female Genes hSlo Humans Ion channel Ion Channel Gating Large-Conductance Calcium-Activated Potassium Channel alpha Subunits Large-Conductance Calcium-Activated Potassium Channels Maxi-K channel Membrane Proteins - biosynthesis Membrane Proteins - drug effects Membrane Proteins - genetics Molecular Sequence Data Nerve Tissue Proteins - biosynthesis Nerve Tissue Proteins - genetics Oocytes Peptides - pharmacology Polymerase Chain Reaction Potassium Channels, Calcium-Activated Recombinant Fusion Proteins - biosynthesis Sequence Alignment Sequence Homology, Amino Acid Species Specificity Substantia Nigra - chemistry Xenopus laevis
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