Blends of synthetic and natural polymers as drug delivery systems for growth hormone
In order to overcome the biological deficiencies of synthetic polymers and to enhance the mechanical characteristics of natural polymers, two synthetic polymers, poly(vinyl alcohol) (PVA) and poly(acrylic acid) (PAA) were blended, in different ratios, with two biological polymers, collagen (C) and h...
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| Veröffentlicht in: | Biomaterials 1995-05, Vol.16 (7), p.569-574 |
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| creator | Cascone, Maria Grazia Sim, Bushra Sandra, Downes |
| description | In order to overcome the biological deficiencies of synthetic polymers and to enhance the mechanical characteristics of natural polymers, two synthetic polymers, poly(vinyl alcohol) (PVA) and poly(acrylic acid) (PAA) were blended, in different ratios, with two biological polymers, collagen (C) and hyaluronic acid (HA). These blends were used to prepare films, sponges and hydrogels which were loaded with growth hormone (GH) to investigate their potential use as drug delivery systems. The GH release was monitored
in vitro using a specific enzyme-linked immunosorbent assay. The results show that GH can be released from HA/PAA sponges and from HA/PVA and C/PVA hydrogels. The initial GH concentration used for sample loading affected the total quantity of GH released but not the pattern of release. The rate and quantity of GH released was significantly dependent on the HA or C content of the polymers. |
| doi_str_mv | 10.1016/0142-9612(95)91131-H |
| format | Article |
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in vitro using a specific enzyme-linked immunosorbent assay. The results show that GH can be released from HA/PAA sponges and from HA/PVA and C/PVA hydrogels. The initial GH concentration used for sample loading affected the total quantity of GH released but not the pattern of release. The rate and quantity of GH released was significantly dependent on the HA or C content of the polymers.</description><identifier>ISSN: 0142-9612</identifier><identifier>EISSN: 1878-5905</identifier><identifier>DOI: 10.1016/0142-9612(95)91131-H</identifier><identifier>PMID: 7492722</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Acrylic Resins - chemistry ; Acrylic Resins - metabolism ; Animals ; Biological and medical sciences ; Biomechanical Phenomena ; Biopolymers ; collagen ; Collagen - chemistry ; Collagen - metabolism ; Delayed-Action Preparations ; Drug delivery ; Drug Delivery Systems - standards ; Gels - chemistry ; General pharmacology ; growth hormone ; Growth Hormone - administration & dosage ; Growth Hormone - metabolism ; Humans ; hyaluronic acid ; Hyaluronic Acid - chemistry ; Hyaluronic Acid - metabolism ; Medical sciences ; Microscopy, Electron, Scanning ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Polyvinyl Alcohol - chemistry ; Polyvinyl Alcohol - metabolism ; Recombinant Proteins - metabolism ; Recombinant Proteins - pharmacokinetics</subject><ispartof>Biomaterials, 1995-05, Vol.16 (7), p.569-574</ispartof><rights>1995</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c510t-4dc28c7845ba322d8fd80cc1427d3407ed5a6f98b4e7a42d2820266067ce736e3</citedby><cites>FETCH-LOGICAL-c510t-4dc28c7845ba322d8fd80cc1427d3407ed5a6f98b4e7a42d2820266067ce736e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0142-9612(95)91131-H$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3502172$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7492722$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cascone, Maria Grazia</creatorcontrib><creatorcontrib>Sim, Bushra</creatorcontrib><creatorcontrib>Sandra, Downes</creatorcontrib><title>Blends of synthetic and natural polymers as drug delivery systems for growth hormone</title><title>Biomaterials</title><addtitle>Biomaterials</addtitle><description>In order to overcome the biological deficiencies of synthetic polymers and to enhance the mechanical characteristics of natural polymers, two synthetic polymers, poly(vinyl alcohol) (PVA) and poly(acrylic acid) (PAA) were blended, in different ratios, with two biological polymers, collagen (C) and hyaluronic acid (HA). These blends were used to prepare films, sponges and hydrogels which were loaded with growth hormone (GH) to investigate their potential use as drug delivery systems. The GH release was monitored
in vitro using a specific enzyme-linked immunosorbent assay. The results show that GH can be released from HA/PAA sponges and from HA/PVA and C/PVA hydrogels. The initial GH concentration used for sample loading affected the total quantity of GH released but not the pattern of release. The rate and quantity of GH released was significantly dependent on the HA or C content of the polymers.</description><subject>Acrylic Resins - chemistry</subject><subject>Acrylic Resins - metabolism</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biomechanical Phenomena</subject><subject>Biopolymers</subject><subject>collagen</subject><subject>Collagen - chemistry</subject><subject>Collagen - metabolism</subject><subject>Delayed-Action Preparations</subject><subject>Drug delivery</subject><subject>Drug Delivery Systems - standards</subject><subject>Gels - chemistry</subject><subject>General pharmacology</subject><subject>growth hormone</subject><subject>Growth Hormone - administration & dosage</subject><subject>Growth Hormone - metabolism</subject><subject>Humans</subject><subject>hyaluronic acid</subject><subject>Hyaluronic Acid - chemistry</subject><subject>Hyaluronic Acid - metabolism</subject><subject>Medical sciences</subject><subject>Microscopy, Electron, Scanning</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Polyvinyl Alcohol - chemistry</subject><subject>Polyvinyl Alcohol - metabolism</subject><subject>Recombinant Proteins - metabolism</subject><subject>Recombinant Proteins - pharmacokinetics</subject><issn>0142-9612</issn><issn>1878-5905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFqGzEQhkVJSJ20b9CADqG0h00lrVZaXQJtSOOAoRf3LGRpNlbYXbma3QS_fda18TE5DcN8M_PzEfKFs2vOuPrBuBSFUVx8M9V3w3nJi_kHMuO1rovKsOqEzI7IR3KO-MSmnklxRs60NEILMSPLXy30AWlqKG77YQ1D9NT1gfZuGLNr6Sa12w4yUoc05PGRBmjjM-TtxOMAHdImZfqY08uwpuuUu9TDJ3LauBbh86FekL-_75a382Lx5_7h9uei8BVnQyGDF7XXtaxWrhQi1E2omfdTZh1KyTSEyqnG1CsJ2kkRRC2YUIop7UGXCsoL8nV_d5PTvxFwsF1ED23rekgjWq21EkKyd0GuTGmmtxMo96DPCTFDYzc5di5vLWd2Z93ulNqdUmsq-9-6nU9rl4f746qDcFw6aJ7mV4e5Q-_aJrveRzxiZcUE1zvsZo_BJO05QrboI_QeQszgBxtSfDvHKzwCnb8</recordid><startdate>19950501</startdate><enddate>19950501</enddate><creator>Cascone, Maria Grazia</creator><creator>Sim, Bushra</creator><creator>Sandra, Downes</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19950501</creationdate><title>Blends of synthetic and natural polymers as drug delivery systems for growth hormone</title><author>Cascone, Maria Grazia ; Sim, Bushra ; Sandra, Downes</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c510t-4dc28c7845ba322d8fd80cc1427d3407ed5a6f98b4e7a42d2820266067ce736e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Acrylic Resins - chemistry</topic><topic>Acrylic Resins - metabolism</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biomechanical Phenomena</topic><topic>Biopolymers</topic><topic>collagen</topic><topic>Collagen - chemistry</topic><topic>Collagen - metabolism</topic><topic>Delayed-Action Preparations</topic><topic>Drug delivery</topic><topic>Drug Delivery Systems - standards</topic><topic>Gels - chemistry</topic><topic>General pharmacology</topic><topic>growth hormone</topic><topic>Growth Hormone - administration & dosage</topic><topic>Growth Hormone - metabolism</topic><topic>Humans</topic><topic>hyaluronic acid</topic><topic>Hyaluronic Acid - chemistry</topic><topic>Hyaluronic Acid - metabolism</topic><topic>Medical sciences</topic><topic>Microscopy, Electron, Scanning</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Polyvinyl Alcohol - chemistry</topic><topic>Polyvinyl Alcohol - metabolism</topic><topic>Recombinant Proteins - metabolism</topic><topic>Recombinant Proteins - pharmacokinetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cascone, Maria Grazia</creatorcontrib><creatorcontrib>Sim, Bushra</creatorcontrib><creatorcontrib>Sandra, Downes</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cascone, Maria Grazia</au><au>Sim, Bushra</au><au>Sandra, Downes</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Blends of synthetic and natural polymers as drug delivery systems for growth hormone</atitle><jtitle>Biomaterials</jtitle><addtitle>Biomaterials</addtitle><date>1995-05-01</date><risdate>1995</risdate><volume>16</volume><issue>7</issue><spage>569</spage><epage>574</epage><pages>569-574</pages><issn>0142-9612</issn><eissn>1878-5905</eissn><abstract>In order to overcome the biological deficiencies of synthetic polymers and to enhance the mechanical characteristics of natural polymers, two synthetic polymers, poly(vinyl alcohol) (PVA) and poly(acrylic acid) (PAA) were blended, in different ratios, with two biological polymers, collagen (C) and hyaluronic acid (HA). These blends were used to prepare films, sponges and hydrogels which were loaded with growth hormone (GH) to investigate their potential use as drug delivery systems. The GH release was monitored
in vitro using a specific enzyme-linked immunosorbent assay. The results show that GH can be released from HA/PAA sponges and from HA/PVA and C/PVA hydrogels. The initial GH concentration used for sample loading affected the total quantity of GH released but not the pattern of release. The rate and quantity of GH released was significantly dependent on the HA or C content of the polymers.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>7492722</pmid><doi>10.1016/0142-9612(95)91131-H</doi><tpages>6</tpages></addata></record> |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Acrylic Resins - chemistry Acrylic Resins - metabolism Animals Biological and medical sciences Biomechanical Phenomena Biopolymers collagen Collagen - chemistry Collagen - metabolism Delayed-Action Preparations Drug delivery Drug Delivery Systems - standards Gels - chemistry General pharmacology growth hormone Growth Hormone - administration & dosage Growth Hormone - metabolism Humans hyaluronic acid Hyaluronic Acid - chemistry Hyaluronic Acid - metabolism Medical sciences Microscopy, Electron, Scanning Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polyvinyl Alcohol - chemistry Polyvinyl Alcohol - metabolism Recombinant Proteins - metabolism Recombinant Proteins - pharmacokinetics |
| title | Blends of synthetic and natural polymers as drug delivery systems for growth hormone |
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