Molecular Cloning, Expression Pattern, and Chromosomal Localization of Human CDKN2D/INK4d,an Inhibitor of Cyclin D-Dependent Kinases

Progression through the G1 phase of the cell cycle is dependent on the activity of holoenzymes formed between D-type cyclins and their catalytic partners, the cyclin-dependent kinases cdk4 and cdk6. p16INK4a,p15INK4b, and p18INK4c, a group of structurally related proteins, function as specific inhib...

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Veröffentlicht in:	Genomics 1995-10, Vol.29 (3), p.623-630
Hauptverfasser:	OKUDA, TSUKASA, HIRAI, HIROSHI, VALENTINE, VIRGINIA A., SHURTLEFF, SHEILA A., KIDD, VINCENT J., LAHTI, JILL M., SHERR, CHARLES J., DOWNING, JAMES R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Base Sequence Biological and medical sciences BIOLOGY AND MEDICINE, BASIC STUDIES Carrier Proteins - biosynthesis Carrier Proteins - genetics CELL CYCLE Cell Cycle Proteins Child CHILDREN CHROMOSOMAL ABERRATIONS Chromosome Mapping Chromosomes, Human, Pair 1 Chromosomes, Human, Pair 19 Cloning, Molecular Consensus Sequence Cyclin-Dependent Kinase Inhibitor p16 Cyclin-Dependent Kinase Inhibitor p19 Cyclin-Dependent Kinases - antagonists & inhibitors DNA HYBRIDIZATION DNA Primers DNA SEQUENCING DNA-CLONING ENZYME ACTIVITY ENZYME INHIBITORS Fetus FLUORESCENCE Fundamental and applied biological sciences. Psychology Gene Deletion Gene Expression GENE MUTATIONS GENE REGULATION Genes. Genome GENETIC MAPPING Genetic Variation HeLa Cells Homozygote HUMAN CHROMOSOME 1 HUMAN CHROMOSOME 19 Humans In Situ Hybridization, Fluorescence LEUKEMIA Male Mice Molecular and cellular biology Molecular genetics Molecular Sequence Data Organ Specificity PHOSPHOTRANSFERASES Polymerase Chain Reaction Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Sequence Homology, Amino Acid TISSUE DISTRIBUTION Translocation, Genetic
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