Phenytoin and plasmapheresis : importance of sampling times and impact of obesity

The effect of plasmapheresis (PP) on total and free phenytoin clearance is reported. An obese patient with the diagnosis of thrombotic thrombocytopenic purpura (TTP) was treated with PP. Twelve episodes of PP, having exchange volumes of 1.5-2.25 times the plasma volume with a mean +/- SD 7.7 +/- 0.8...

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Veröffentlicht in:	Therapeutic drug monitoring 1994-12, Vol.16 (6), p.624-628
Hauptverfasser:	OLSEN, K. M, MARX, M. A, MONAGHAN, M. S, BARNES, E, ACKERMAN, B. H, PAPPAS, A. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Blood Specimen Collection Epilepsy, Tonic-Clonic - drug therapy Humans Male Medical sciences Middle Aged Neuropharmacology Obesity, Morbid - complications Obesity, Morbid - metabolism Pharmacology. Drug treatments Phenytoin - blood Phenytoin - pharmacokinetics Phenytoin - therapeutic use Plasmapheresis Purpura, Thrombocytopenic - blood Purpura, Thrombocytopenic - complications Purpura, Thrombocytopenic - therapy Time Factors
Online-Zugang:	Volltext
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