Immunogenicity and HIV-1 virus neutralization of MN recombinant glycoprotein 120/HIV-1 QS21 vaccine in baboons

The effect of adjuvant and immunization schedule on the immunogenicity of HIV-1 envelope glycoprotein, MN rgp120, was optimized by using baboons. The novel adjuvant QS21 elicited earlier seroconversion than alum adjuvant, and the antibody titers to MN rgp120 for animals treated with QS21 were signif...

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Veröffentlicht in:	AIDS research and human retroviruses 1994, Vol.10, p.S105-S108
Hauptverfasser:	POWELL, M. F, CLELAND, J. L, EASTMAN, D. J, LIM, A, NEWMAN, M. J, NUNBERG, J. H, WEISSBURG, R. P, VENNARI, J. C, WRIN, T, BERMAN, P. W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - administration & dosage AIDS Vaccines - administration & dosage AIDS Vaccines - immunology AIDS/HIV Alum Compounds - administration & dosage Animals Biological and medical sciences HIV Antibodies - biosynthesis HIV Envelope Protein gp120 - administration & dosage HIV Envelope Protein gp120 - immunology HIV Seropositivity - immunology HIV-1 - immunology Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology In Vitro Techniques Medical sciences Neutralization Tests Papio Saponins - administration & dosage Saponins - immunology Vaccines, Synthetic - administration & dosage Vaccines, Synthetic - immunology
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