Serum levels of the pyridinoline crosslinked carboxyterminal telopeptide of type I collagen (ICTP) and osteocalcin in rachitic children in Nigeria
We measured the levels of the pyridinoline crosslinked carboxyterminal telopeptide of type I collagen (ICTP) and osteocalcin (OC) in the serum of 12 rachitic and 27 healthy Nigerian children, and compared the performance of these relatively new markers of bone metabolism with established laboratory...
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| Veröffentlicht in: | Clinical biochemistry 1995-10, Vol.28 (5), p.541-545 |
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| container_title | Clinical biochemistry |
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| creator | Scariano, John K. Walter, Elizabeth A. Glew, Robert H. Hollis, Bruce W. Henry, Allison Ocheke, Isaac Isichei, Christien O. |
| description | We measured the levels of the pyridinoline crosslinked carboxyterminal telopeptide of type I collagen (ICTP) and osteocalcin (OC) in the serum of 12 rachitic and 27 healthy Nigerian children, and compared the performance of these relatively new markers of bone metabolism with established laboratory parameters of skeletal disease.
Active rickets was diagnosed on the basis of clinical and biochemical criteria. Serum calcium and phosphorus concentration and alkaline phosphatase activity were determined using clinically accepted methods. Radioimmunoassay was performed to quantify parathyroid hormone, 1-,25-dihydroxyvitamin D D, OC, and ICTP.
The rachitic children had statistically significant serum elevations of ICTP and osteocalcin as compared with age- and sex-matched controls. Serum levels of ICTP correlated with alkaline phosphate activity.
As a marker of abnormal bone metabolism, ICTP performs at least as well as alkaline phosphate. ICTP and OC are valuable additions to the growing repertoire of bone markers. |
| doi_str_mv | 10.1016/0009-9120(95)00043-9 |
| format | Article |
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Active rickets was diagnosed on the basis of clinical and biochemical criteria. Serum calcium and phosphorus concentration and alkaline phosphatase activity were determined using clinically accepted methods. Radioimmunoassay was performed to quantify parathyroid hormone, 1-,25-dihydroxyvitamin D D, OC, and ICTP.
The rachitic children had statistically significant serum elevations of ICTP and osteocalcin as compared with age- and sex-matched controls. Serum levels of ICTP correlated with alkaline phosphate activity.
As a marker of abnormal bone metabolism, ICTP performs at least as well as alkaline phosphate. ICTP and OC are valuable additions to the growing repertoire of bone markers.</description><identifier>ISSN: 0009-9120</identifier><identifier>EISSN: 1873-2933</identifier><identifier>DOI: 10.1016/0009-9120(95)00043-9</identifier><identifier>PMID: 8582054</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Age Factors ; Alkaline Phosphatase - blood ; biological markers ; Biomarkers - blood ; Bone and Bones - chemistry ; Bone and Bones - metabolism ; bone resorption ; Calcium - blood ; Child ; Child, Preschool ; Collagen - blood ; Collagen - metabolism ; Collagen Type I ; Diet ; Humans ; Infant ; Matched-Pair Analysis ; metabolic bone disease ; Nigeria ; osteocalcin ; Osteocalcin - blood ; Parathyroid Hormone - blood ; Peptides - blood ; Phosphates - blood ; rickets ; Rickets - blood ; Rickets - diagnosis ; Vitamin D - blood</subject><ispartof>Clinical biochemistry, 1995-10, Vol.28 (5), p.541-545</ispartof><rights>1995</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c303t-2271bd77d5fa72a29491e797bf770e934b64d0622b29900472c40bf5cdb80f3c3</citedby><cites>FETCH-LOGICAL-c303t-2271bd77d5fa72a29491e797bf770e934b64d0622b29900472c40bf5cdb80f3c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0009-9120(95)00043-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8582054$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Scariano, John K.</creatorcontrib><creatorcontrib>Walter, Elizabeth A.</creatorcontrib><creatorcontrib>Glew, Robert H.</creatorcontrib><creatorcontrib>Hollis, Bruce W.</creatorcontrib><creatorcontrib>Henry, Allison</creatorcontrib><creatorcontrib>Ocheke, Isaac</creatorcontrib><creatorcontrib>Isichei, Christien O.</creatorcontrib><title>Serum levels of the pyridinoline crosslinked carboxyterminal telopeptide of type I collagen (ICTP) and osteocalcin in rachitic children in Nigeria</title><title>Clinical biochemistry</title><addtitle>Clin Biochem</addtitle><description>We measured the levels of the pyridinoline crosslinked carboxyterminal telopeptide of type I collagen (ICTP) and osteocalcin (OC) in the serum of 12 rachitic and 27 healthy Nigerian children, and compared the performance of these relatively new markers of bone metabolism with established laboratory parameters of skeletal disease.
Active rickets was diagnosed on the basis of clinical and biochemical criteria. Serum calcium and phosphorus concentration and alkaline phosphatase activity were determined using clinically accepted methods. Radioimmunoassay was performed to quantify parathyroid hormone, 1-,25-dihydroxyvitamin D D, OC, and ICTP.
The rachitic children had statistically significant serum elevations of ICTP and osteocalcin as compared with age- and sex-matched controls. Serum levels of ICTP correlated with alkaline phosphate activity.
As a marker of abnormal bone metabolism, ICTP performs at least as well as alkaline phosphate. ICTP and OC are valuable additions to the growing repertoire of bone markers.</description><subject>Age Factors</subject><subject>Alkaline Phosphatase - blood</subject><subject>biological markers</subject><subject>Biomarkers - blood</subject><subject>Bone and Bones - chemistry</subject><subject>Bone and Bones - metabolism</subject><subject>bone resorption</subject><subject>Calcium - blood</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Collagen - blood</subject><subject>Collagen - metabolism</subject><subject>Collagen Type I</subject><subject>Diet</subject><subject>Humans</subject><subject>Infant</subject><subject>Matched-Pair Analysis</subject><subject>metabolic bone disease</subject><subject>Nigeria</subject><subject>osteocalcin</subject><subject>Osteocalcin - blood</subject><subject>Parathyroid Hormone - blood</subject><subject>Peptides - blood</subject><subject>Phosphates - blood</subject><subject>rickets</subject><subject>Rickets - blood</subject><subject>Rickets - diagnosis</subject><subject>Vitamin D - blood</subject><issn>0009-9120</issn><issn>1873-2933</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkduKFDEQhoMo67j6Bgq5kt2L1py607kRlsHDwKKC63VIJ9W70XSnTTKL8xo-sZkDe6kQqFTq_6tCfQi9pOQNJbR7SwhRjaKMXKj2siaCN-oRWtFe8oYpzh-j1YPkKXqW84-aMtF3Z-isb3tGWrFCf75B2k44wD2EjOOIyx3gZZe883MMfgZsU8y53n6Cw9akIf7eFUiTn03ABUJcYCnewcG7WwBvsI0hmFuY8cVmffP1EpvZ4ZgLRGuC9TOuJxl754u3uIbgEhweP_tbSN48R09GEzK8OMVz9P3D-5v1p-b6y8fN-uq6sZzw0jAm6eCkdO1oJDNMCUVBKjmMUhJQXAydcKRjbGBK1e1IZgUZxta6oScjt_wcvT72XVL8tYVc9OSzhfr3GeI2ayllqxRn_xXStm6bd6IKxVF42FmCUS_JTybtNCV6z0zvgeg9EK1afWCmVbW9OvXfDhO4B9MJUq2_O9YrIrj3kHS2HmYLziewRbvo_z3gL_yOpxs</recordid><startdate>199510</startdate><enddate>199510</enddate><creator>Scariano, John K.</creator><creator>Walter, Elizabeth A.</creator><creator>Glew, Robert H.</creator><creator>Hollis, Bruce W.</creator><creator>Henry, Allison</creator><creator>Ocheke, Isaac</creator><creator>Isichei, Christien O.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>199510</creationdate><title>Serum levels of the pyridinoline crosslinked carboxyterminal telopeptide of type I collagen (ICTP) and osteocalcin in rachitic children in Nigeria</title><author>Scariano, John K. ; Walter, Elizabeth A. ; Glew, Robert H. ; Hollis, Bruce W. ; Henry, Allison ; Ocheke, Isaac ; Isichei, Christien O.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c303t-2271bd77d5fa72a29491e797bf770e934b64d0622b29900472c40bf5cdb80f3c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Age Factors</topic><topic>Alkaline Phosphatase - blood</topic><topic>biological markers</topic><topic>Biomarkers - blood</topic><topic>Bone and Bones - chemistry</topic><topic>Bone and Bones - metabolism</topic><topic>bone resorption</topic><topic>Calcium - blood</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Collagen - blood</topic><topic>Collagen - metabolism</topic><topic>Collagen Type I</topic><topic>Diet</topic><topic>Humans</topic><topic>Infant</topic><topic>Matched-Pair Analysis</topic><topic>metabolic bone disease</topic><topic>Nigeria</topic><topic>osteocalcin</topic><topic>Osteocalcin - blood</topic><topic>Parathyroid Hormone - blood</topic><topic>Peptides - blood</topic><topic>Phosphates - blood</topic><topic>rickets</topic><topic>Rickets - blood</topic><topic>Rickets - diagnosis</topic><topic>Vitamin D - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Scariano, John K.</creatorcontrib><creatorcontrib>Walter, Elizabeth A.</creatorcontrib><creatorcontrib>Glew, Robert H.</creatorcontrib><creatorcontrib>Hollis, Bruce W.</creatorcontrib><creatorcontrib>Henry, Allison</creatorcontrib><creatorcontrib>Ocheke, Isaac</creatorcontrib><creatorcontrib>Isichei, Christien O.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Scariano, John K.</au><au>Walter, Elizabeth A.</au><au>Glew, Robert H.</au><au>Hollis, Bruce W.</au><au>Henry, Allison</au><au>Ocheke, Isaac</au><au>Isichei, Christien O.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum levels of the pyridinoline crosslinked carboxyterminal telopeptide of type I collagen (ICTP) and osteocalcin in rachitic children in Nigeria</atitle><jtitle>Clinical biochemistry</jtitle><addtitle>Clin Biochem</addtitle><date>1995-10</date><risdate>1995</risdate><volume>28</volume><issue>5</issue><spage>541</spage><epage>545</epage><pages>541-545</pages><issn>0009-9120</issn><eissn>1873-2933</eissn><abstract>We measured the levels of the pyridinoline crosslinked carboxyterminal telopeptide of type I collagen (ICTP) and osteocalcin (OC) in the serum of 12 rachitic and 27 healthy Nigerian children, and compared the performance of these relatively new markers of bone metabolism with established laboratory parameters of skeletal disease.
Active rickets was diagnosed on the basis of clinical and biochemical criteria. Serum calcium and phosphorus concentration and alkaline phosphatase activity were determined using clinically accepted methods. Radioimmunoassay was performed to quantify parathyroid hormone, 1-,25-dihydroxyvitamin D D, OC, and ICTP.
The rachitic children had statistically significant serum elevations of ICTP and osteocalcin as compared with age- and sex-matched controls. Serum levels of ICTP correlated with alkaline phosphate activity.
As a marker of abnormal bone metabolism, ICTP performs at least as well as alkaline phosphate. ICTP and OC are valuable additions to the growing repertoire of bone markers.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>8582054</pmid><doi>10.1016/0009-9120(95)00043-9</doi><tpages>5</tpages></addata></record> |
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| ispartof | Clinical biochemistry, 1995-10, Vol.28 (5), p.541-545 |
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| subjects | Age Factors Alkaline Phosphatase - blood biological markers Biomarkers - blood Bone and Bones - chemistry Bone and Bones - metabolism bone resorption Calcium - blood Child Child, Preschool Collagen - blood Collagen - metabolism Collagen Type I Diet Humans Infant Matched-Pair Analysis metabolic bone disease Nigeria osteocalcin Osteocalcin - blood Parathyroid Hormone - blood Peptides - blood Phosphates - blood rickets Rickets - blood Rickets - diagnosis Vitamin D - blood |
| title | Serum levels of the pyridinoline crosslinked carboxyterminal telopeptide of type I collagen (ICTP) and osteocalcin in rachitic children in Nigeria |
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