Regulation of an oligodendrocyte progenitor cell line by the interleukin-6 family of cytokines

We report pleiotropic actions of the interleukin‐6 family of cytokines on a rat cerebral cortical oligodendrocyte cell line, Central Glia‐4 (CG‐4). This is a bipotential oligodendrocyte type‐2 astrocyte (O‐2A) progenitor cell line that can be manipulated in vitro to become either a type‐2 astrocyte...

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Veröffentlicht in:	Glia 1994-09, Vol.12 (2), p.87-98
Hauptverfasser:	Kahn, M. A., de Vellis, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Astrocytes - cytology Astrocytes - drug effects Astrocytes - metabolism Biological and medical sciences Blotting, Western Cell Line Cell Survival - drug effects Cerebral Cortex Ciliary Neurotrophic Factor CNTF Cytokines - pharmacology Differentiation ERGs Fundamental and applied biological sciences. Psychology Gene Expression - drug effects Glial Fibrillary Acidic Protein - analysis Glial Fibrillary Acidic Protein - biosynthesis Growth Inhibitors - pharmacology IL-6 Immunohistochemistry - methods Interleukin-6 - pharmacology Isolated neuron and nerve. Neuroglia Kinetics Leukemia Inhibitory Factor LIF Lymphokines - pharmacology Myelin Basic Protein - analysis Myelin Basic Protein - biosynthesis Nerve Growth Factors - pharmacology Nerve Tissue Proteins - pharmacology Oligodendroglia - cytology Oligodendroglia - drug effects Oligodendroglia - metabolism Stem Cells - cytology Stem Cells - drug effects Stem Cells - metabolism Survival Type-2 astrocyte Vertebrates: nervous system and sense organs
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