Actions of (±)-7-hydroxy- N, N-dipropylaminotetralin (7-OH-DPAT) on dopamine synthesis in limbic and extrapyramidal regions of rat brain
The proposed D 3-selective ligand (±)-7-hydroxy- N, N-dipropylaminotetralin (7-OH-DPAT) inhibited tyrosine hydroxylase in vitro (IC 50 = 0.6–0.7 μM) and dihydroxyphenylalanine (DOPA) accimulation in vivo (ID 50 = 4.8–6.4 mg/kg) in two autoreceptor models in extrapyramidal and limbic tissue in rat fo...
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| Veröffentlicht in: | Brain research 1994-10, Vol.662 (1), p.283-288 |
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| creator | Booth, Raymond G. Baldessarini, Ross J. Marsh, Elda Owens, Constance E. |
| description | The proposed D
3-selective ligand (±)-7-hydroxy-
N,
N-dipropylaminotetralin (7-OH-DPAT) inhibited tyrosine hydroxylase in vitro (IC
50 = 0.6–0.7
μM) and dihydroxyphenylalanine (DOPA) accimulation in vivo (ID
50 = 4.8–6.4 mg/kg) in two autoreceptor models in extrapyramidal and limbic tissue in rat forebrain, without consistent regional selectivity. Some limbic selectivity (ID
50 = 10 vs. 29 mg/kg) was found in an in vivo model permitting expression of postsynaptic D
3 and D
2 receptor activity. The effects were partially blocked by
S(−)-eticlopride alone, and fully after reserpine pretreatment. The results suggest that 7-OH-DPAT activates D
3 or D
2 autoreceptors, alters dopamine storage or release, and may interact with some limbic selectivity at postsynaptic D
3 and D
2 receptors as a partial agonist. |
| doi_str_mv | 10.1016/0006-8993(94)90827-3 |
| format | Article |
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3-selective ligand (±)-7-hydroxy-
N,
N-dipropylaminotetralin (7-OH-DPAT) inhibited tyrosine hydroxylase in vitro (IC
50 = 0.6–0.7
μM) and dihydroxyphenylalanine (DOPA) accimulation in vivo (ID
50 = 4.8–6.4 mg/kg) in two autoreceptor models in extrapyramidal and limbic tissue in rat forebrain, without consistent regional selectivity. Some limbic selectivity (ID
50 = 10 vs. 29 mg/kg) was found in an in vivo model permitting expression of postsynaptic D
3 and D
2 receptor activity. The effects were partially blocked by
S(−)-eticlopride alone, and fully after reserpine pretreatment. The results suggest that 7-OH-DPAT activates D
3 or D
2 autoreceptors, alters dopamine storage or release, and may interact with some limbic selectivity at postsynaptic D
3 and D
2 receptors as a partial agonist.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(94)90827-3</identifier><identifier>PMID: 7859086</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>(±)-7-Hydroxy- N, N-dipropylaminotetralin ; 7-OH-DPAT ; Aminotetralin ; Animals ; Autoreceptor ; Biological and medical sciences ; Central nervous system ; Central neurotransmission. Neuromudulation. Pathways and receptors ; D 2 ; D 3 ; Dihydroxyphenylalanine - metabolism ; Dopamine ; Dopamine - biosynthesis ; Dopamine Agonists - pharmacology ; Dopamine D2 Receptor Antagonists ; Extrapyramidal Tracts - cytology ; Extrapyramidal Tracts - drug effects ; Extrapyramidal Tracts - metabolism ; Fundamental and applied biological sciences. Psychology ; Limbic System - cytology ; Limbic System - drug effects ; Limbic System - metabolism ; Male ; Rats ; Rats, Sprague-Dawley ; Receptor ; Receptors, Dopamine - drug effects ; Receptors, Dopamine - metabolism ; Receptors, Dopamine D3 ; Reserpine - pharmacology ; Salicylamides - pharmacology ; Stereoisomerism ; Tetrahydronaphthalenes - pharmacology ; Tyrosine 3-Monooxygenase - metabolism ; Tyrosine hydroxylase ; Vertebrates: nervous system and sense organs</subject><ispartof>Brain research, 1994-10, Vol.662 (1), p.283-288</ispartof><rights>1994</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-7fcc82c33aa995d0984e64ca39ef6bcefc4f9cb8610cdca7986e20678a28cec93</citedby><cites>FETCH-LOGICAL-c417t-7fcc82c33aa995d0984e64ca39ef6bcefc4f9cb8610cdca7986e20678a28cec93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-8993(94)90827-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3299577$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7859086$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Booth, Raymond G.</creatorcontrib><creatorcontrib>Baldessarini, Ross J.</creatorcontrib><creatorcontrib>Marsh, Elda</creatorcontrib><creatorcontrib>Owens, Constance E.</creatorcontrib><title>Actions of (±)-7-hydroxy- N, N-dipropylaminotetralin (7-OH-DPAT) on dopamine synthesis in limbic and extrapyramidal regions of rat brain</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>The proposed D
3-selective ligand (±)-7-hydroxy-
N,
N-dipropylaminotetralin (7-OH-DPAT) inhibited tyrosine hydroxylase in vitro (IC
50 = 0.6–0.7
μM) and dihydroxyphenylalanine (DOPA) accimulation in vivo (ID
50 = 4.8–6.4 mg/kg) in two autoreceptor models in extrapyramidal and limbic tissue in rat forebrain, without consistent regional selectivity. Some limbic selectivity (ID
50 = 10 vs. 29 mg/kg) was found in an in vivo model permitting expression of postsynaptic D
3 and D
2 receptor activity. The effects were partially blocked by
S(−)-eticlopride alone, and fully after reserpine pretreatment. The results suggest that 7-OH-DPAT activates D
3 or D
2 autoreceptors, alters dopamine storage or release, and may interact with some limbic selectivity at postsynaptic D
3 and D
2 receptors as a partial agonist.</description><subject>(±)-7-Hydroxy- N, N-dipropylaminotetralin</subject><subject>7-OH-DPAT</subject><subject>Aminotetralin</subject><subject>Animals</subject><subject>Autoreceptor</subject><subject>Biological and medical sciences</subject><subject>Central nervous system</subject><subject>Central neurotransmission. Neuromudulation. Pathways and receptors</subject><subject>D 2</subject><subject>D 3</subject><subject>Dihydroxyphenylalanine - metabolism</subject><subject>Dopamine</subject><subject>Dopamine - biosynthesis</subject><subject>Dopamine Agonists - pharmacology</subject><subject>Dopamine D2 Receptor Antagonists</subject><subject>Extrapyramidal Tracts - cytology</subject><subject>Extrapyramidal Tracts - drug effects</subject><subject>Extrapyramidal Tracts - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Limbic System - cytology</subject><subject>Limbic System - drug effects</subject><subject>Limbic System - metabolism</subject><subject>Male</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptor</subject><subject>Receptors, Dopamine - drug effects</subject><subject>Receptors, Dopamine - metabolism</subject><subject>Receptors, Dopamine D3</subject><subject>Reserpine - pharmacology</subject><subject>Salicylamides - pharmacology</subject><subject>Stereoisomerism</subject><subject>Tetrahydronaphthalenes - pharmacology</subject><subject>Tyrosine 3-Monooxygenase - metabolism</subject><subject>Tyrosine hydroxylase</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAUhS0EKkPhDUDyAqEZCYMTZ_yzQRq1QJGqlkVZW87NDTVKnMHOoOYReJy-Ak-GwwyzhJVlne8c3-tDyPOCvyl4Id9yziXTxoilqVaG61Ix8YAsCq1KJsuKPySLI_KYPEnpW74KYfgJOVF6nR1yQX5uYPRDSHRo6fLX_Yopdjs1cbibGL16Ta9Y47dx2E6d630YRhyj63ygS8WuL9j5583Nig6BNsN21pGmKYy3mHyiGep8X3ugLjQU77JxO8VMNa6jEb_-fTS6kdbR-fCUPGpdl_DZ4TwlXz68vzm7YJfXHz-dbS4ZVIUamWoBdAlCOGfMuuFGVygrcMJgK2vAFqrWQK1lwaEBp4yWWHKptCs1IBhxSl7tc_Ne33eYRtv7BNh1LuCwS1YptdayFP8FCynXRqoyg9UehDikFLG12-h7FydbcDtXZece7NyDNZX9U5Wd818c8nd1j83RdOgm6y8Pukvguja6AD4dMVHm_ZXK2Ls9hvnTfniMNoHHANj4iDDaZvD_nuM3uF2w4w</recordid><startdate>19941031</startdate><enddate>19941031</enddate><creator>Booth, Raymond G.</creator><creator>Baldessarini, Ross J.</creator><creator>Marsh, Elda</creator><creator>Owens, Constance E.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19941031</creationdate><title>Actions of (±)-7-hydroxy- N, N-dipropylaminotetralin (7-OH-DPAT) on dopamine synthesis in limbic and extrapyramidal regions of rat brain</title><author>Booth, Raymond G. ; Baldessarini, Ross J. ; Marsh, Elda ; Owens, Constance E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-7fcc82c33aa995d0984e64ca39ef6bcefc4f9cb8610cdca7986e20678a28cec93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>(±)-7-Hydroxy- N, N-dipropylaminotetralin</topic><topic>7-OH-DPAT</topic><topic>Aminotetralin</topic><topic>Animals</topic><topic>Autoreceptor</topic><topic>Biological and medical sciences</topic><topic>Central nervous system</topic><topic>Central neurotransmission. Neuromudulation. Pathways and receptors</topic><topic>D 2</topic><topic>D 3</topic><topic>Dihydroxyphenylalanine - metabolism</topic><topic>Dopamine</topic><topic>Dopamine - biosynthesis</topic><topic>Dopamine Agonists - pharmacology</topic><topic>Dopamine D2 Receptor Antagonists</topic><topic>Extrapyramidal Tracts - cytology</topic><topic>Extrapyramidal Tracts - drug effects</topic><topic>Extrapyramidal Tracts - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Limbic System - cytology</topic><topic>Limbic System - drug effects</topic><topic>Limbic System - metabolism</topic><topic>Male</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptor</topic><topic>Receptors, Dopamine - drug effects</topic><topic>Receptors, Dopamine - metabolism</topic><topic>Receptors, Dopamine D3</topic><topic>Reserpine - pharmacology</topic><topic>Salicylamides - pharmacology</topic><topic>Stereoisomerism</topic><topic>Tetrahydronaphthalenes - pharmacology</topic><topic>Tyrosine 3-Monooxygenase - metabolism</topic><topic>Tyrosine hydroxylase</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Booth, Raymond G.</creatorcontrib><creatorcontrib>Baldessarini, Ross J.</creatorcontrib><creatorcontrib>Marsh, Elda</creatorcontrib><creatorcontrib>Owens, Constance E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Booth, Raymond G.</au><au>Baldessarini, Ross J.</au><au>Marsh, Elda</au><au>Owens, Constance E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Actions of (±)-7-hydroxy- N, N-dipropylaminotetralin (7-OH-DPAT) on dopamine synthesis in limbic and extrapyramidal regions of rat brain</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1994-10-31</date><risdate>1994</risdate><volume>662</volume><issue>1</issue><spage>283</spage><epage>288</epage><pages>283-288</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>The proposed D
3-selective ligand (±)-7-hydroxy-
N,
N-dipropylaminotetralin (7-OH-DPAT) inhibited tyrosine hydroxylase in vitro (IC
50 = 0.6–0.7
μM) and dihydroxyphenylalanine (DOPA) accimulation in vivo (ID
50 = 4.8–6.4 mg/kg) in two autoreceptor models in extrapyramidal and limbic tissue in rat forebrain, without consistent regional selectivity. Some limbic selectivity (ID
50 = 10 vs. 29 mg/kg) was found in an in vivo model permitting expression of postsynaptic D
3 and D
2 receptor activity. The effects were partially blocked by
S(−)-eticlopride alone, and fully after reserpine pretreatment. The results suggest that 7-OH-DPAT activates D
3 or D
2 autoreceptors, alters dopamine storage or release, and may interact with some limbic selectivity at postsynaptic D
3 and D
2 receptors as a partial agonist.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>7859086</pmid><doi>10.1016/0006-8993(94)90827-3</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-8993 |
| ispartof | Brain research, 1994-10, Vol.662 (1), p.283-288 |
| issn | 0006-8993 1872-6240 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77758623 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | (±)-7-Hydroxy- N, N-dipropylaminotetralin 7-OH-DPAT Aminotetralin Animals Autoreceptor Biological and medical sciences Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors D 2 D 3 Dihydroxyphenylalanine - metabolism Dopamine Dopamine - biosynthesis Dopamine Agonists - pharmacology Dopamine D2 Receptor Antagonists Extrapyramidal Tracts - cytology Extrapyramidal Tracts - drug effects Extrapyramidal Tracts - metabolism Fundamental and applied biological sciences. Psychology Limbic System - cytology Limbic System - drug effects Limbic System - metabolism Male Rats Rats, Sprague-Dawley Receptor Receptors, Dopamine - drug effects Receptors, Dopamine - metabolism Receptors, Dopamine D3 Reserpine - pharmacology Salicylamides - pharmacology Stereoisomerism Tetrahydronaphthalenes - pharmacology Tyrosine 3-Monooxygenase - metabolism Tyrosine hydroxylase Vertebrates: nervous system and sense organs |
| title | Actions of (±)-7-hydroxy- N, N-dipropylaminotetralin (7-OH-DPAT) on dopamine synthesis in limbic and extrapyramidal regions of rat brain |
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