Contraction Band Necrosis: Its Modification by the Free Radical Scavenger N-2-Mercaptopropionyl Glycine

Contraction band necrosis (CBN) may represent infarct extension from free radical generation during reperfusion. We sought to limit CBN with the free radical scavenger N-2-mercaptopropionyl glycine (MPG, 20 mg/kg). Sixteen chronically instrumented Beagles (8 control, and 8 MPG treated) underwent 90-...

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Veröffentlicht in:	Journal of cardiovascular pharmacology 1994-11, Vol.24 (5), p.694-701
Hauptverfasser:	Widman, Stephen C, Liang, Chang-seng, Schenk, Eric A, Hood, William B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antianginal agents. Coronary vasodilator agents Biological and medical sciences Blood Pressure - drug effects Cardiovascular system Coronary Circulation - drug effects Coronary Disease - pathology Disease Models, Animal Dogs Female Free Radical Scavengers - pharmacology Free Radical Scavengers - therapeutic use Heart Rate - drug effects Male Medical sciences Microspheres Myocardial Contraction - drug effects Myocardial Infarction - drug therapy Myocardial Infarction - pathology Myocardial Ischemia - drug therapy Myocardial Reperfusion Injury - drug therapy Myocardial Reperfusion Injury - pathology Myocardium - pathology Necrosis Paraffin Embedding Pharmacology. Drug treatments Random Allocation Tiopronin - administration & dosage Tiopronin - pharmacology Tiopronin - therapeutic use
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