A subunit gIV vaccine, produced by transfected mammalian cells in culture, induces mucosal immunity against bovine herpesvirus-1 in cattle

A truncated version of bovine herpesvirus-1 (BHV-1) glycoprotein 1 V (tgIV V) was produced in a novel, non-destructive expression system based upon regulation of gene expression by the bovine heat-shock protein 70A (hsp70) gene promoter in Madin Dal-by bovine kidney (MDBK) cells. In this system, up...

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Veröffentlicht in:	Vaccine 1994, Vol.12 (14), p.1295-1302
Hauptverfasser:	van Drunen Littel-van den Hurk, S., Van Donkersgoed, J., Kowalski, J., van den Hurk, J.V., Harland, R., Babiuk, L.A., Zamb, T.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Viral - biosynthesis Antibodies, Viral - blood Biological and medical sciences Blotting, Western - veterinary Bovine herpesvirus-I Cattle Cattle Diseases - immunology Cattle Diseases - prevention & control Cell Line Enzyme-Linked Immunosorbent Assay - veterinary Fundamental and applied biological sciences. Psychology Herpesviridae Infections - immunology Herpesviridae Infections - prevention & control Herpesviridae Infections - veterinary Herpesvirus 1, Bovine - immunology Microbiology mucosal immunity Nasal Mucosa - immunology Neutralization Tests - veterinary recombinant glycoprotein IV Transfection Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Vaccines, Synthetic - administration & dosage Vaccines, Synthetic - biosynthesis Vaccines, Synthetic - immunology Viral Proteins - administration & dosage Viral Proteins - biosynthesis Viral Proteins - immunology Viral Vaccines - immunology Virology
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