Mice deficient for the CD40 ligand

To study the Potential roles of CD40L in immune responses, we generated CD40L-deficient mice by gene targeting. Similar to the effects of CD40L mutations in humans (hyper-IgM syndrome), CD40L-deficient mice have a decreased IgM response to thymus-dependent antigens, fail altogether to produce an ant...

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Veröffentlicht in:Immunity (Cambridge, Mass.) Mass.), 1994-08, Vol.1 (5), p.423-431
Hauptverfasser: Xu, Jianchao, Foy, Teresa M., Laman, Jon D., Elliott, Eileen A., Dunn, Jonathan J., Waldschmidt, Thomas J., Elsemore, Jennifer, Noelle, Randolph J., Flavell, Richard A.
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Sprache:eng
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Zusammenfassung:To study the Potential roles of CD40L in immune responses, we generated CD40L-deficient mice by gene targeting. Similar to the effects of CD40L mutations in humans (hyper-IgM syndrome), CD40L-deficient mice have a decreased IgM response to thymus-dependent antigens, fail altogether to produce an antigen-specific IgG1 response following Immunization, yet respond normally to a T-Independent antigen, TNP-Ficoll. Moreover, these mice do not develop germinal centers in response to thymus-dependent antigens, suggesting an inability to develop memory B cell responses. Although CD40L-deficient mice have low levels of most circulating immunoglobulin isotypes, they do not exhibit the spontaneous hyper-IgM syndrome seen in humans, at least up to 12 weeks of age. In summary, our study confirms the important role of CD40-CD40L interactions in thymus-dependent humoral immune responses and germinal center formation.
ISSN:1074-7613
1097-4180
DOI:10.1016/1074-7613(94)90073-6