t(15;17) Hypergranular Acute Promyelocytic Leukemia (M3) Developing into a t(3;6) M3 without t(15;17) at Relapse
This report describes a case of acute promyelocytic leukemia (APL) M3. At diagnosis. the specific t(15;17) translocation was observed. After chemotherapy including retinoic acid. a complete remission was achieved and the karyotype became normal. At relapse of the M3 leukemia, the t(15;17) clone was...
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| Veröffentlicht in: | Leukemia & lymphoma 1995-09, Vol.19 (1-2), p.185-188 |
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| container_title | Leukemia & lymphoma |
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| creator | Desangles, F. Vilain, E. Arborio, M. De Revel, T. Flandrin, G. |
| description | This report describes a case of acute promyelocytic leukemia (APL) M3. At diagnosis. the specific t(15;17) translocation was observed. After chemotherapy including retinoic acid. a complete remission was achieved and the karyotype became normal. At relapse of the M3 leukemia, the t(15;17) clone was no longer observed but a t(3;6) translocation was then detected. Several hypotheses for this unusual cytogenetic course of APL are discussed. |
| doi_str_mv | 10.3109/10428199509059675 |
| format | Article |
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| fulltext | fulltext |
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| ispartof | Leukemia & lymphoma, 1995-09, Vol.19 (1-2), p.185-188 |
| issn | 1042-8194 1029-2403 |
| language | eng |
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| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Adult Antineoplastic Combined Chemotherapy Protocols - therapeutic use Bone Marrow - pathology Chromosome Mapping Chromosomes, Human, Pair 15 Chromosomes, Human, Pair 17 Chromosomes, Human, Pair 3 Chromosomes, Human, Pair 6 Cytarabine - administration & dosage Daunorubicin - administration & dosage Humans Karyotyping Leukemia, Promyelocytic, Acute - drug therapy Leukemia, Promyelocytic, Acute - genetics Leukemia, Promyelocytic, Acute - pathology Male Polymerase Chain Reaction Recurrence Translocation, Genetic Tretinoin - therapeutic use |
| title | t(15;17) Hypergranular Acute Promyelocytic Leukemia (M3) Developing into a t(3;6) M3 without t(15;17) at Relapse |
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