Nucleotide and deduced amino acid sequences of the matrix (M) and fusion (F) protein genes of cetacean morbilliviruses isolated from a porpoise and a dolphin
Morbilliviruses have been isolated from stranded dolphins and porpoises. The present paper describes the cloning and sequencing of the porpoise morbillivirus (PMV) F gene and of the dolphin morbillivirus (DMV) M and F genes and their flanking regions. The gene order of the DMV genome appeared to be...
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| Veröffentlicht in: | Virus research 1994-12, Vol.34 (3), p.291-304 |
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| creator | Bolt, Gert Blixenkrone-Møller, Merete Gottschalck, Elisabeth Wishaupt, Richard G.A. Welsh, Mark J. Earle, J A.Philip Rima, Bertus K. |
| description | Morbilliviruses have been isolated from stranded dolphins and porpoises. The present paper describes the cloning and sequencing of the porpoise morbillivirus (PMV) F gene and of the dolphin morbillivirus (DMV) M and F genes and their flanking regions. The gene order of the DMV genome appeared to be identical to that of other morbilliviruses, A genomic untranslated region of 837 nucleotides was found between the translated DMV M and F gene regions. The predicted DMV M protein were highly conserved with those of other morbilliviruses. Both the deduced PMV and DMV F
0 proteins exhibited three major hydrophobic regions as well as a cysteine rich region, a leucine zipper motif and a cleavage motif allowing cleavage of the F
0 protein into F
1 and F
2 subunits. Apparently the DMV F
0 cleavage motif was not modified by adaptation of DMV to Vero cells. The predicted PMV and DMV F proteins were 94% identical. Comparisons with the corresponding sequences of other morbilliviruses demonstrated that the cetacean morbillivirus does not derive from any known morbillivirus but represents an independent morbillivirus lineage. |
| doi_str_mv | 10.1016/0168-1702(94)90129-5 |
| format | Article |
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0 proteins exhibited three major hydrophobic regions as well as a cysteine rich region, a leucine zipper motif and a cleavage motif allowing cleavage of the F
0 protein into F
1 and F
2 subunits. Apparently the DMV F
0 cleavage motif was not modified by adaptation of DMV to Vero cells. The predicted PMV and DMV F proteins were 94% identical. Comparisons with the corresponding sequences of other morbilliviruses demonstrated that the cetacean morbillivirus does not derive from any known morbillivirus but represents an independent morbillivirus lineage.</description><identifier>ISSN: 0168-1702</identifier><identifier>EISSN: 1872-7492</identifier><identifier>DOI: 10.1016/0168-1702(94)90129-5</identifier><identifier>PMID: 7531923</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Amino Acid Sequence ; Animals ; Base Sequence ; Cercopithecus aethiops ; Cetacea - virology ; DNA, Viral ; Dolphin morbillivirus ; Dolphins - virology ; F gene ; Genes, Viral ; M gene ; Molecular Sequence Data ; morbillivirus ; Morbillivirus - classification ; Morbillivirus - genetics ; Phylogeny ; Porpoise morbillivirus ; RNA ; RNA, Viral ; Sequence analysis ; Sequence Homology, Amino Acid ; Sequence Homology, Nucleic Acid ; Vero Cells ; Viral Fusion Proteins - genetics ; Viral Matrix Proteins - genetics</subject><ispartof>Virus research, 1994-12, Vol.34 (3), p.291-304</ispartof><rights>1994</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-ac23bd003f487975adc19d834a49f6a4bc78e567e709a348a1b7df488d3ff9283</citedby><cites>FETCH-LOGICAL-c388t-ac23bd003f487975adc19d834a49f6a4bc78e567e709a348a1b7df488d3ff9283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0168170294901295$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7531923$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bolt, Gert</creatorcontrib><creatorcontrib>Blixenkrone-Møller, Merete</creatorcontrib><creatorcontrib>Gottschalck, Elisabeth</creatorcontrib><creatorcontrib>Wishaupt, Richard G.A.</creatorcontrib><creatorcontrib>Welsh, Mark J.</creatorcontrib><creatorcontrib>Earle, J A.Philip</creatorcontrib><creatorcontrib>Rima, Bertus K.</creatorcontrib><title>Nucleotide and deduced amino acid sequences of the matrix (M) and fusion (F) protein genes of cetacean morbilliviruses isolated from a porpoise and a dolphin</title><title>Virus research</title><addtitle>Virus Res</addtitle><description>Morbilliviruses have been isolated from stranded dolphins and porpoises. The present paper describes the cloning and sequencing of the porpoise morbillivirus (PMV) F gene and of the dolphin morbillivirus (DMV) M and F genes and their flanking regions. The gene order of the DMV genome appeared to be identical to that of other morbilliviruses, A genomic untranslated region of 837 nucleotides was found between the translated DMV M and F gene regions. The predicted DMV M protein were highly conserved with those of other morbilliviruses. Both the deduced PMV and DMV F
0 proteins exhibited three major hydrophobic regions as well as a cysteine rich region, a leucine zipper motif and a cleavage motif allowing cleavage of the F
0 protein into F
1 and F
2 subunits. Apparently the DMV F
0 cleavage motif was not modified by adaptation of DMV to Vero cells. The predicted PMV and DMV F proteins were 94% identical. Comparisons with the corresponding sequences of other morbilliviruses demonstrated that the cetacean morbillivirus does not derive from any known morbillivirus but represents an independent morbillivirus lineage.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Cercopithecus aethiops</subject><subject>Cetacea - virology</subject><subject>DNA, Viral</subject><subject>Dolphin morbillivirus</subject><subject>Dolphins - virology</subject><subject>F gene</subject><subject>Genes, Viral</subject><subject>M gene</subject><subject>Molecular Sequence Data</subject><subject>morbillivirus</subject><subject>Morbillivirus - classification</subject><subject>Morbillivirus - genetics</subject><subject>Phylogeny</subject><subject>Porpoise morbillivirus</subject><subject>RNA</subject><subject>RNA, Viral</subject><subject>Sequence analysis</subject><subject>Sequence Homology, Amino Acid</subject><subject>Sequence Homology, Nucleic Acid</subject><subject>Vero Cells</subject><subject>Viral Fusion Proteins - genetics</subject><subject>Viral Matrix Proteins - genetics</subject><issn>0168-1702</issn><issn>1872-7492</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFuFSEUhonR1NvqG2jCyty7GAsDM8DGxDS2mrR1o2vCwMFiZmCEmUYfpu_qTOemS10QFuf7z-HwIfSGkveU0PZ8ObKigtR7xQ-K0FpVzTO0o1LUleCqfo52T8hLdFrKT0JIy0R7gk5Ew6iq2Q493M62hzQFB9hEhx242YLDZggxYWODwwV-zRAtFJw8nu4AD2bK4Tfe3xweI34uIUW8vzzgMacJQsQ_IG64hclYMBEPKXeh78N9yHNZaqGk3kzLIJ_TgA0eUx5TKNsjDHapH-9CfIVeeNMXeH28z9D3y0_fLj5X11-vvlx8vK4sk3KqjK1Z5whhnkuhRGOcpcpJxg1XvjW8s0JC0woQRBnGpaGdcAsrHfNe1ZKdoXdb32WBZdky6SEUC31vIqS5aCFEwwlr_wvSVjSEq2YB-QbanErJ4PWYw2DyH02JXvXp1Y1e3WjF9aM-vcbeHvvP3QDuKXT0tdQ_bHVYfuM-QNbFhlWOCxnspF0K_x7wFyuNquw</recordid><startdate>19941201</startdate><enddate>19941201</enddate><creator>Bolt, Gert</creator><creator>Blixenkrone-Møller, Merete</creator><creator>Gottschalck, Elisabeth</creator><creator>Wishaupt, Richard G.A.</creator><creator>Welsh, Mark J.</creator><creator>Earle, J A.Philip</creator><creator>Rima, Bertus K.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>8FD</scope><scope>F1W</scope><scope>FR3</scope><scope>H94</scope><scope>H99</scope><scope>L.F</scope><scope>L.G</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19941201</creationdate><title>Nucleotide and deduced amino acid sequences of the matrix (M) and fusion (F) protein genes of cetacean morbilliviruses isolated from a porpoise and a dolphin</title><author>Bolt, Gert ; Blixenkrone-Møller, Merete ; Gottschalck, Elisabeth ; Wishaupt, Richard G.A. ; Welsh, Mark J. ; Earle, J A.Philip ; Rima, Bertus K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-ac23bd003f487975adc19d834a49f6a4bc78e567e709a348a1b7df488d3ff9283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Cercopithecus aethiops</topic><topic>Cetacea - virology</topic><topic>DNA, Viral</topic><topic>Dolphin morbillivirus</topic><topic>Dolphins - virology</topic><topic>F gene</topic><topic>Genes, Viral</topic><topic>M gene</topic><topic>Molecular Sequence Data</topic><topic>morbillivirus</topic><topic>Morbillivirus - classification</topic><topic>Morbillivirus - genetics</topic><topic>Phylogeny</topic><topic>Porpoise morbillivirus</topic><topic>RNA</topic><topic>RNA, Viral</topic><topic>Sequence analysis</topic><topic>Sequence Homology, Amino Acid</topic><topic>Sequence Homology, Nucleic Acid</topic><topic>Vero Cells</topic><topic>Viral Fusion Proteins - genetics</topic><topic>Viral Matrix Proteins - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bolt, Gert</creatorcontrib><creatorcontrib>Blixenkrone-Møller, Merete</creatorcontrib><creatorcontrib>Gottschalck, Elisabeth</creatorcontrib><creatorcontrib>Wishaupt, Richard G.A.</creatorcontrib><creatorcontrib>Welsh, Mark J.</creatorcontrib><creatorcontrib>Earle, J A.Philip</creatorcontrib><creatorcontrib>Rima, Bertus K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ASFA: Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Virus research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bolt, Gert</au><au>Blixenkrone-Møller, Merete</au><au>Gottschalck, Elisabeth</au><au>Wishaupt, Richard G.A.</au><au>Welsh, Mark J.</au><au>Earle, J A.Philip</au><au>Rima, Bertus K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nucleotide and deduced amino acid sequences of the matrix (M) and fusion (F) protein genes of cetacean morbilliviruses isolated from a porpoise and a dolphin</atitle><jtitle>Virus research</jtitle><addtitle>Virus Res</addtitle><date>1994-12-01</date><risdate>1994</risdate><volume>34</volume><issue>3</issue><spage>291</spage><epage>304</epage><pages>291-304</pages><issn>0168-1702</issn><eissn>1872-7492</eissn><abstract>Morbilliviruses have been isolated from stranded dolphins and porpoises. The present paper describes the cloning and sequencing of the porpoise morbillivirus (PMV) F gene and of the dolphin morbillivirus (DMV) M and F genes and their flanking regions. The gene order of the DMV genome appeared to be identical to that of other morbilliviruses, A genomic untranslated region of 837 nucleotides was found between the translated DMV M and F gene regions. The predicted DMV M protein were highly conserved with those of other morbilliviruses. Both the deduced PMV and DMV F
0 proteins exhibited three major hydrophobic regions as well as a cysteine rich region, a leucine zipper motif and a cleavage motif allowing cleavage of the F
0 protein into F
1 and F
2 subunits. Apparently the DMV F
0 cleavage motif was not modified by adaptation of DMV to Vero cells. The predicted PMV and DMV F proteins were 94% identical. Comparisons with the corresponding sequences of other morbilliviruses demonstrated that the cetacean morbillivirus does not derive from any known morbillivirus but represents an independent morbillivirus lineage.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>7531923</pmid><doi>10.1016/0168-1702(94)90129-5</doi><tpages>14</tpages></addata></record> |
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| identifier | ISSN: 0168-1702 |
| ispartof | Virus research, 1994-12, Vol.34 (3), p.291-304 |
| issn | 0168-1702 1872-7492 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77754036 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Amino Acid Sequence Animals Base Sequence Cercopithecus aethiops Cetacea - virology DNA, Viral Dolphin morbillivirus Dolphins - virology F gene Genes, Viral M gene Molecular Sequence Data morbillivirus Morbillivirus - classification Morbillivirus - genetics Phylogeny Porpoise morbillivirus RNA RNA, Viral Sequence analysis Sequence Homology, Amino Acid Sequence Homology, Nucleic Acid Vero Cells Viral Fusion Proteins - genetics Viral Matrix Proteins - genetics |
| title | Nucleotide and deduced amino acid sequences of the matrix (M) and fusion (F) protein genes of cetacean morbilliviruses isolated from a porpoise and a dolphin |
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